1GGE,1DGF,1A4E,1M7S,3EJ6


Conserved Protein Domain Family
catalase
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cd00328: catalase 
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Catalase heme-binding enzyme
Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Most catalases exist as tetramers of 65KD subunits containing a protoheme IX group buried deep inside the structure. In eukaryotic cells, catalases are located in peroxisomes.
Links
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Statistics
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PSSM-Id: 163705
Aligned: 7 rows
Threshold Bit Score: 400.684
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding pocket [chemical binding site]
Evidence:
  • Structure:1GGE_A: Escherichia coli catalase HPII binds heme, contacts calculated at 4A.
  • Comment:these residues are conserved in all heme-catalases
  • Structure:1A4E: Saccharomyces cerevisiae catalase A binds heme, contacts calculated at 4A
  • Citation:PMID 9931255
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                      #                                 
1GGE_A    121 RIPERIVHARGSAAHGYFQPYkSLSdiTKADFLSDpNKITPVFVRFSTVQGGAGSADTVRDIRGFATKFYTEEGIFDLVG 200 Escherichia coli
1DGF_A     64 RIPERVVHAKGAGAFGYFEVThDITkySKAKVFEHiGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVG 143 human
1A4E_A     49 NIPQRNPHAHGSGAFGYFEVTdDITdiCGSAMFSKiGKRTKCLTRFSTVGGDKGSADTVRDPRGFATKFYTEEGNLDWVY 128 baker's yeast
1M7S_A     45 RIPERVVHARGTGVKGEFTASaDISdlSKATVFKS-GEKTPVFVRFSSVVHGNHSPETLRDPHGFATKFYTADGNWDLVG 123 Pseudomonas syringae
P11934     54 EAVERAAHAAAAAAFGAFVARgDWTa-SAAAAFQA-AGKQIAFMAAFSTVAGAKGSATVRDADAFAAKFASAAALQELVG 131 Penicillium janthi...
3EJ6_A     64 RIPERVVHARGAGAHGIFTSYgDWSniTAASFLGAkDKQTPVFVRFSTVAGSRGSADTARDVHGFATRFYTDEGNFDIVG 143 Neurospora crassa
P81138     57 RVPERAVHARGTGAHGTFLSYeDWSnlTAASFLSAeGKFTPEMTRFSTVSGARGSADTARDVHGFATRFYVDEGNFDIVG 136 Penicillium janthi...

Feature 1     #    #         #                                                                
1GGE_A    201 NNTPIFFIQD--AHKFPDFVHAV--KPEPHWAIPqgqsaHDTFWDYVSL--QPETLHNVMWAMS-DRGIPRSYRTMEGFG 273 Escherichia coli
1DGF_A    144 NNTPIFFIRD--PILFPSFIHSQ--KRNPQTHLKd----PDMVWDFWSL--RPESLHQVSFLFS-DRGIPDGHRHMNGYG 212 human
1A4E_A    129 NNTPVFFIRD--PSKFPHFIHTQ--KRNPQTNLRd----ADMFWDFLTTpeNQVAIHQVMILFS-DRGTPANYRSMHGYS 199 baker's yeast
1M7S_A    124 NNFPTFFIRD--AIKFPDMVHAF--KPDPRTNLDn----DSRRFDFFSH--VPEATRTLTLLYS-NEGTPAGYRFMDGNG 192 Pseudomonas syringae
P11934    132 NNSPISFFIF--DLLFAAILFASkaKAANQAAFA-----AAAELAAESLfvRLPSLHQVSFFALaGFAAVAAHRHMNGYG 204 Penicillium janthi...
3EJ6_A    144 NNIPVFFIQD--AIRFPDLIHSV--KPSPDNEVPqaataHDSAWDFFSS--QPSALHTLFWAMS-GNGIPRSYRHMDGFG 216 Neurospora crassa
P81138    137 NNIPVFFIWDviIEPTLMALHAQ--KPNPRFHLPrgqqdPNRISDNLTA--RGDSLAQGSQISS-ERGSPKAYSNTEPNK 211 Penicillium janthi...

Feature 1                                                                                     
1GGE_A    274 IHTFRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGrdpDFHRRELWEAIEAGDFPEYELGFQLIPEEDEFKFDFDL 353 Escherichia coli
1DGF_A    213 SHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQedpDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNP 292 human
1A4E_A    200 GHTYKWSNKNGDWHYVQVHIKTDQGIKNLTIEEATKIAGsnpDYCQQDLFEAIQNGNYPSWTVYIQTMTERDAKKLPFSV 279 baker's yeast
1M7S_A    193 VHAYKLVNAKGEVHYVKFHWKSLQGIKNLDPKEVAQVQSkdySHLTNDLVGAIKKGDFPKWDLYVQVLKPEELAKFDFDP 272 Pseudomonas syringae
P11934    205 SHTFKLVAKDGSVYCSKFWYKADQGQAAEVWKDAEEVAAedvDYFRDLNFQAEAAGRYPLWELASQVMTFSDFEIDPFNE 284 Penicillium janthi...
3EJ6_A    217 IHTFRLVTEDGKSKLVKWHWKTKQGKAALVWEEAQVLAGknaDFHRQDLWDAIESGNAPSWELAVQLIDEDKAQAYGFDL 296 Neurospora crassa
P81138    212 HRSFRLVTDNGKQFQCSNHWQPLQGFIDLGVEEAWRFPEegeGYVAENLFESIELLTVGDEELEIQSMSFNNDLRERFNS 291 Penicillium janthi...

Feature 1                                                                         #   #       
1GGE_A    354 LDPTKLIPEelvPVQRVGKMVLNRNPDNFFAENEQAAFHPGHIVP---GLDFTN--------DPLLQGRLFSYTDTQISR 422 Escherichia coli
1DGF_A    293 FDLTKVWPHkdyPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPP---GIEASP--------DKMLQGRLFAYPDTHRHR 361 human
1A4E_A    280 FDLTKVWPQgqfPLRRVGKIVLNENPLNFFAQVEQAAFAPSTTVP---YQEASA--------DPVLQARLFSYADAHRYR 348 baker's yeast
1M7S_A    273 LDATKIWPDv--PEKKIGQMVLNKNVDNFFQETEQVAMAPANLVP---GIEPSE--------DRLLQGRVFSYADTQMYR 339 Pseudomonas syringae
P11934    285 NIPTKVVPResvPLIVDAELLLNRNPLNMFAEVEQVFMDVAAASKgadEVEDPLiqrqfayiDTHLSELTASYGIPVCRP 364 Penicillium janthi...
3EJ6_A    297 LDPTKFLPEefaPLQVLGEMTLNRNPMNYFAETEQISFQPGHIVR---GVDFTE--------DPLLQGRLYSYLDTQLNR 365 Neurospora crassa
P81138    292 SEVTKSSVVrlvPLITQGKLVFNKNIQMLFNEVIGAMFQPGHIVR---GVDFTE--------DPLLQGRLFSYLDTQLNR 360 Penicillium janthi...

Feature 1                                                                                     
1GGE_A    423 Lg-----------GPNFHEIPINRPT-CPYHNF---QRDGMHRMGIDtn----paNYEPNSindnwpretppgpkrggfe 483 Escherichia coli
1DGF_A    362 L------------GPNYLHIPVNCPYrARVANY---QRDGPMCMQDNqgg---apNYYPNSfgapeqqpsalehsi---- 419 human
1A4E_A    349 L------------GPNFHQIPVNCPYaSKFFNPa--IRDGPMNVNGNfgs---epTYLANDksytyiqqdrpiqqhqe-- 409 baker's yeast
1M7S_A    340 L------------GANGLSLPVNQPK-VAVNNG---NQDGALNTGHTts----gvNYEPSRleprpaddkarysel---- 395 Pseudomonas syringae
P11934    365 YatvlndqedgarYDDVQDVLVIAPN-AFSASAvevQIPAAAAFNLAa-------ARVAAAgdvrvn------------- 423 Penicillium janthi...
3EJ6_A    366 Hr-----------GPNFEQLPINRPV-SGVHNN---HRDGQGQAWIHkn----ihHYSPSYlnkgypaqanqtvgrgfft 426 Neurospora crassa
P81138    361 H------------GPNIQQLGFNRPPrAPIHNN---NRDGAGEMIDLppfasfveTQEWGAkdikqtavgqnkfdqehr- 424 Penicillium janthi...

Feature 1                                                                                     
1GGE_A    484 syqervegnkvrerspsfgEYYSHPRLFWLsq--tPFEQRHIVDGFSFELSKv-vRPYIRERVVDQLAHIDLTLAQAVAK 560 Escherichia coli
1DGF_A    420 -----qysgevrrfntandDNVTQVRAFYVnv-lnEEQRKRLCENIAGHLKDa--QIFIQKKAVKNFTEVHPDYGSHIQA 491 human
1A4E_A    410 --vwngpaipyhwatspgdVDFVQARNLYRvlgkqPGQQKNLAYNIGIHVEGa--CPQIQQRVYDMFARVDKGLSEAIKK 485 baker's yeast
1M7S_A    396 -----plsgttqqakitreQNFKQAGDLYRsy--sAKEKTDLVQKFGESLADt--LTESKNIMLSYLYKEDPNYGTRVAE 466 Pseudomonas syringae
P11934    424 --------------avveaDQRKQSRQFWAsd--vNAQKKRLVDAFRMEVASa-vSASIQVDVTVEFSFVAAAAAARIAA 486 Penicillium janthi...
3EJ6_A    427 tpgrtasgvlnrelsatfdDHYTQPRLFFNsl--tPVEQQFVINAIRFEASHv-tNEQVKKNVLEQLNKISNDVAKRVAV 503 Neurospora crassa
P81138    425 --fshwkfgvngfvhtrndDNVTHARGFFTap--eRGQQKKRVAAFDRMFTVvglSVDGQQANSDQYADFDAAAGKKVAK 500 Penicillium janthi...

Feature 1       
1GGE_A    561 NL 562 Escherichia coli
1DGF_A    492 LL 493 human
1A4E_A    486 VA 487 baker's yeast
1M7S_A    467 VA 468 Pseudomonas syringae
P11934    487 AV 488 Penicillium janthinellum
3EJ6_A    504 AL 505 Neurospora crassa
P81138    501 AI 502 Penicillium janthinellum

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