1A8P,1GAQ,1GVH,1IB0,1AMO,1DDG,1EP2,1JA0,1KRH,1QFJ,1TLL,1TVC,2BF4,2GPJ,2PIA,2QTL,2R6H


Conserved Protein Domain Family
FNR_like

?
cd00322: FNR_like 
Click on image for an interactive view with Cn3D
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in many organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one- electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and 2 electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).
Statistics
?
PSSM-Id: 99778
View PSSM: cd00322
Aligned: 86 rows
Threshold Bit Score: 79.4132
Threshold Setting Gi: 110590386
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                           #                                         
1A8P_A     10 LSVHHwn-----dtLFSFKTTrnp------slrFENGQFVMIglevd-----------------------------grpl 49  Azotobacter vinela...
1GAQ_A     43 LLNTKitgddapgeTWHMVFSteg------kipYREGQSIGViadgvdk-------------------------ngkphk 91  maize
1QFJ_A      8 TSVEAit-----dtVYRVRIVpda------afsFRAGQYLMVvmde--------------------------------rd 44  Escherichia coli
1TVC_A     16 VGLNWvs-----snTVQFLLQkrpdecgnrgvkFEPGQFMDLtipg-------------------------------tdv 59  Methylococcus caps...
2GPJ_A     14 IRSTYit-----phXLRITLGgagla---gfpaDQESAYIKLlfpqag----------------------------erpl 57  Shewanella putrefa...
2R6H_A     15 LSNKNvs-----tfIKEFVVKlpeg----etxnFKSGSYAQIkipkyniryadydiqdrfrgdwdkxdawsltckneeet 85  Porphyromonas ging...
AAC45296  120 VATEPlt-----hdILKVTIQtdr------pvhYLAGRYANVrvpg-------------------------------wpr 157 Pseudomonas chloro...
YP_802323  10 VKNIVkt-----dgSATITFVskng-----plnFLGGQYVIFnsglktp--------------------------egkvi 53  Leptospira borgpet...
YP_932724 115 VGISAlt-----hdIRRLDVEleq------pirFWAGQFVDItlpe-------------------------------kgi 152 Azoarcus sp. BH72
YP_933354 110 SRIESlt-----ptIKGVWVKldep----egmrFQAGQYINLhlpd-------------------------------gig 149 Azoarcus sp. BH72
Feature 1      ####                 ###                   ####                                
1A8P_A     50 mRAYSIASpnye-----ehlEFFSIKVq---------------nGPLTSRLqhl-keGDELMVSrkptgtlvtsdllpgK 108 Azotobacter vinela...
1GAQ_A     92 vRLYSIASsaigdfgdsktvSLCVKRLiytnda------geivkGVCSNFLcdl-qpGDNVQITgpvgkem-lmpkdpnA 163 maize
1QFJ_A     45 kRPFSMAStpde----kgfiELHIGASe---------------iNLYAKAVmdrilkDHQIVVDiphgeaw--lrddeeR 103 Escherichia coli
1TVC_A     60 sRSYSPANlpnp----egrlEFLIRVLp---------------eGRFSDYLrndarvGQVLSVKgplgvfg--lkergmA 118 Methylococcus caps...
2GPJ_A     58 xRTYTIRQqrd------deiDVDFVLHdt--------------dGPASSWAkta-qvGELIQIGgpglkk---linfeaD 113 Shewanella putrefa...
2R6H_A     86 vRAYSXANypae----gniiTLNVRIAtppfdraankwkagikpGISSSYIfsl-kpGDKVXXSgpygdf---hiqdtdA 157 Porphyromonas ging...
AAC45296  158 fRCYSFANapqrk--grnvlEFYIRKVp---------------aGEFTEALfrgeldGQPLEMEapqgtf---hlhggdA 217 Pseudomonas chloro...
YP_802323  54 kRAYSIFSsdl------qqeEFQICIQpi-------------qgGPASNHIpnl-aiGSVLEFSgpwgkfignpdwpkkG 113 Leptospira borgpet...
YP_932724 153 tRSYSMASvpss----pgqvSFIIKKYp---------------nGAFSTALdtelkpGDPVLVKgpyggcf--rreerpG 211 Azoarcus sp. BH72
YP_933354 150 tRAFSIASapsa----ageiELNIRIVa---------------gGQGTAYVheklkaGDAIRITgpygrff--vkksakV 208 Azoarcus sp. BH72
Feature 1             #                                                                       
1A8P_A    109 HLYMLSTGTGLaPFMSLIQDpevye-----rfekVVLIHGVRqvnelAYQQFItehlpqseyfgeavkeklIYYPTVtre 183 Azotobacter vinela...
1GAQ_A    164 TIIMLATGTGIaPFRSFLWKmffekhddykfnglGWLFLGVPtssslLYKEEFgkmker-------apenfRVDYAVsre 236 maize
1QFJ_A    104 PMILIAGGTGFsYARSILLTalarn-----pnrdITIYWGGReeqhlYDLCELealsl--------khpglQVVPVVeqp 170 Escherichia coli
1TVC_A    119 PRYFVAGGTGLaPVVSMVRQmqewt-----apneTRIYFGVNtepelFYIDELksler--------smrnlTVKACVwhp 185 Methylococcus caps...
2GPJ_A    114 WFLLAGDXTALpAISVNLAKlpn--------navGYAVIEVLse--aDIQPLVhpe-------------hvELHWVInpe 170 Shewanella putrefa...
2R6H_A    158 EXLYIGGGAGXaPLRAQILHlfrtl----ktgrkVSYWYGARskneiFYEEDFreier--------efpnfKFHIALsdp 225 Porphyromonas ging...
AAC45296  218 PMLCIAGGSGLaPLVSILEHaranr-----ikrdCILLFGARtegdlYQLEAIgniaan-------wqgefRFIPVLshe 285 Pseudomonas chloro...
YP_802323 114 RTLLVATDTGItAINSILHSsrwkfk---lkettVLWFLFPKek-svPVQEVLqrlp-----------kefHFLNVIhip 178 Leptospira borgpet...
YP_932724 212 PMVLIGGGSGMsPLWSILNDhiesg-----eqrpIRFFYGARtrrdlFYLEQFaefeq--------kvpdfRFIPALsaa 278 Azoarcus sp. BH72
YP_933354 209 PVVFMAGGSGLsSPRSMILDlleeg-----fdlpITLVYGQRsraelYYHDEFlalaq--------rhpnfRYVPALshe 275 Azoarcus sp. BH72
Feature 1                                                                                 
1A8P_A    184 sfhnqgrltdlmrsgklfediglppinpqddraMICGSpsmldESCEVldgfglkis-------prmgepgdYLIE 252 Azotobacter vinelandii
1GAQ_A    237 qtnaagermyiqtrmaeykeelwellkkdntyvYMCGLkgmekGIDDImvslaekdgidwfdykkqlkrgdqWNVE 312 maize
1QFJ_A    171 eagwrgrtgtvl------tavlqdhgtlaehdiYIAGRfemakIARDLfcsern-------------aredrLFGD 227 Escherichia coli
1TVC_A    186 sgdwegeqgspid-----alredlessdanpdiYLCGPpgmidAACELvrsrg--------------ipgeqVFFE 242 Methylococcus capsulatus
2GPJ_A    171 adpegrplver---------iaqlpwlagepavWIACEfnsxrALRRHfkqaha-------------lpkshFYTS 224 Shewanella putrefaciens
2R6H_A    226 qpednwtgyvgfihqviydnylkdhdapedieyYXCGPgpxanAVKGXlenlg--------------vprnxLFFD 287 Porphyromonas gingival...
AAC45296  286 pehsdwtgargl------vtehipadfcegaegYLCGPppmidAAIARlldnr--------------lplekIFYD 341 Pseudomonas chlororaphis
YP_802323 179 kinhpnrkeecir-----sfiekldssmfptsaFLAGDgklirALKDIllmrg--------------mneedIGME 235 Leptospira borgpeterse...
YP_932724 279 epedgwtgetgyihevvartlkeegfdgasidaYTCGPapmidAITPVlhmag--------------vppdqMYFD 340 Azoarcus sp. BH72
YP_933354 276 pegsdwngfrgfvh---eaakaafdndfrghkaYLCGPplmidACITTlmqgr--------------lferdIYME 334 Azoarcus sp. BH72

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap