1QPG,16PK,1PHP,1HDI,1VPE


Conserved Protein Domain Family
Phosphoglycerate_kinase
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cd00318: Phosphoglycerate_kinase 
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Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.
Links
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Statistics
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PSSM-Id: 238195
Aligned: 26 rows
Threshold Bit Score: 517.192
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Citation:PMID 2191956
  • Structure:1QPG; yeast phosphoglycerate kinase
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     # #             #                       #                       
1QPG        8 VQDLDLKD-KRVFIRVDFNVPLDGk-KITSNQRIVAALPTIKYVLEHHprYVVLASHLGQPNGer--------------- 70  baker's yeast
1VPE        5 IRDVDLKG-KRVIMRVDFNVPVKDg-VVQDDTRIRAALPTIKYALEQGa-KVILLSHLGRPKGep--------------- 66  Thermotoga maritima
129909      9 IDDAVVKG-KKVLIRVDFNVPVKNg-EITNDFRIRSALPTIQKVLKEGg-SCILMSHLGRPKGakmsdpkpa-------- 77  Crithidia fasciculata
NP_218977   6 CKDVTMRG-ERVVVRVDFNVPMRDg-MVQDDTRVTAAVPTLRYIIEQGprHVVLISHLGDPTRdadkaegnakkd----- 78  Treponema pallidum
129907     14 VDDIWPVAgKRVLIRVDFNVPTSSg-GIDDDFRIRSAIPTIRRIVDQGg-ICILISHLGRPTGvdydtahaeqekrqtpv 91  Crithidia fasciculata
129927      4 LLDLDPKG-KRVLVRVDYNVPVQDg-KVQDETRILESLPTLRHLLAGGa-SLVLLSHLGRPKGpd--------------- 65  Thermus thermophilus
1172459     9 LLEEGVSG-RCVLVRCDLNVPLGDdgAITDLGRVTASVPTLKALLEAGa-KIVVAAHLGRPKNgp--------------- 71  Mycobacterium leprae
NP_600801   9 LLDEGVDG-RHVIVRSDFNVPLNDdrEITDKGRIIASLPTLKALSEGGa-KVIVMAHLGRPKGev--------------- 71  Corynebacterium gl...
129920      6 MTDLDLAG-KRVFIRADLNVPVKDg-KVTSDARIRASLPTIELALKQGa-KVMVTSHLGRPTEgey-------------- 68  Escherichia coli
129931      6 LDDIGDVKgKRVLVREDLNVPMDGd-RVTDDTRLRAAIPTVNELAEKGa-KVLILAHFGRPKGqp--------------- 68  Zymomonas mobilis

Feature 1                                                                                     
1QPG          --------------------------------------------------------------------------------     baker's yeast
1VPE          --------------------------------------------------------------------------------     Thermotoga maritima
129909     78 --------------------------------------------------------------------------ksvrgy 83  Crithidia fasciculata
NP_218977  79 ----------------------------------------------------------------------gcpfdrhafi 88  Treponema pallidum
129907     92 qlpnsrgktaffsglrgdakatilawssqrekaatlsnpygsgktavfarlpeeekrrlllrfmsehkeelfpqlgsagy 171 Crithidia fasciculata
129927        --------------------------------------------------------------------------------     Thermus thermophilus
1172459       --------------------------------------------------------------------------------     Mycobacterium leprae
NP_600801     --------------------------------------------------------------------------------     Corynebacterium gl...
129920        --------------------------------------------------------------------------------     Escherichia coli
129931        --------------------------------------------------------------------------------     Zymomonas mobilis

Feature 1                                                           #                         
1QPG       71 neKYSLAPVAKELQSLLgkDVTFLNDcvgp----eveAAVKASapGSVILLENLRYHIEEEGsrkvdgqkvkaskedVQK 146 baker's yeast
1VPE       67 spEFSLAPVAKRLSELLgkEVKFVPAvvgd----evkKAVEELkeGEVLLLENTRFHPGETKn--------------DPE 128 Thermotoga maritima
129909     84 eeAATLRPVAARLSELLgqKVEFAPDcld------aaSYAAKLkgGDVLLLENVRFYAEEGSkke----------eeRDA 147 Crithidia fasciculata
NP_218977  89 ngKHRLKPVADCLAKKLgvPVHFAPScvg------qrEFIEGLpdGSVVLLENVRFHPEETSgda----------kvQEQ 152 Treponema pallidum
129907    172 ekEFSLEPVAVKLAELLdqHVYFGHDclg------aqADIAKLrcGEVMLLENLRFYTNENSsde----------rkRML 235 Crithidia fasciculata
129927     66 -pKYSLAPVGEALRAHLp-EARFAPFppgs---eearREAEALrpGEVLLLENVRFEPGEEKn--------------DPE 126 Thermus thermophilus
1172459    72 dpKLSLEPVAAALGEQLgqNVQLVCStdrspvggdalACVERLtdGDLLLLQNIRFDPRETSkvdd-------erlaLAK 144 Mycobacterium leprae
NP_600801  72 neKYSLAPVAEALSDELgqYVALAADvvge----dahERANGLteGDILLLENVRFDPRETSkdea-------ertaFAQ 140 Corynebacterium gl...
129920     69 neEFSLLPVVNYLKDKLsnPVRLVKDy---------lDGVDVAe-GELVVLENVRFNKGEKKd--------------DET 124 Escherichia coli
129931     69 npEMSLARIKDALAGVLgrPVHFINDikge----aaaKAVDALnpGAVALLENTRFYAGEEKn--------------DPA 130 Zymomonas mobilis

Feature 1                                                                                     
1QPG      147 FRHELSSLADVYINDAFGTAHRAHSSMVGFdl--pQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNL 224 baker's yeast
1VPE      129 LAKFWASLADIHVNDAFGTAHRAHASNVGIaq-fiPSVAGFLMEKEIKFLSKVTYNPEKPYVVVLGGAKVSDKIGVITNL 207 Thermotoga maritima
129909    148 MAKVLAAYGDVYVSDAFGTAHRDSADMTGIpkvlgAGYAGYLMEKEINYFAQVLNNPPRPLVAIVGGAKVSDKIQLLDNM 227 Crithidia fasciculata
NP_218977 153 FARELAQYGDIFVNDAFGTAHREHASTVVLprlmrRRVAGLLIEREVRYLEPMVCNPKVPMVAVVGGAKVSSKIAVLESL 232 Treponema pallidum
129907    236 MARILASYADVYINDAFGTAHRDSASLTGIprvlqQGAAGYLMEKEISYFSKVLNNPPRPLLAIIGGAKLSDKMQVLENL 315 Crithidia fasciculata
129927    127 LSARYARLGEAFVLDAFGSAHRAHASVVGVar-llPAYAGFLMEKEVRALSRLLKDPERPYAVVLGGAKVSDKIGVIESL 205 Thermus thermophilus
1172459   145 QLVELVGSAGAFVSDGFGVVHRRQASVYDVat-llPHYAGILVADEIRILEQLTSSAKRPYAVVLGGSKVSDKLGVIESL 223 Mycobacterium leprae
NP_600801 141 ELAALAADNGAFVSDGFGVVHRAQTSVYDIak-llPHYAGGLVETEISVLEKIAESPEAPYVVVLGGSKVSDKIGVIEAL 219 Corynebacterium gl...
129920    125 LSKKYAALCDVFVMDAFGTAHRAQASTHGIgkfadVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSL 204 Escherichia coli
129931    131 LAAEVAKLGDFYVNDAFSAAHRAHVSTEGLah-klPAFAGRAMQKELEALEAALGKPTHPVAAVVGGAKVSTKLDVLTNL 209 Zymomonas mobilis

Feature 1                                                                                     
1QPG      225 LDKVDSIIIGGGMAFTFKKVLeNTEIGDSIFDkAGAEIVPKLMekakakgVEVVLPVDFIIADAfsadantKTVTDkegI 304 baker's yeast
1VPE      208 MEKADRILIGGAMMFTFLKAL-GKEVGSSRVEeDKIDLAKELVekakekgVEIVLPVDAVIAQKiepgvekKVVRIddgI 286 Thermotoga maritima
129909    228 LGRINYLVIGGAMAYTFQKAQ-GHAIGISMCEeDKLDLAKSLLkkaqernVEVLLPVDHVCNKEfqgvdapLVTKDv-eI 305 Crithidia fasciculata
NP_218977 233 LRTSTALIIGGGMAYTFLKAQ-GVGVGTSLVEdDFIDTARMLLqkaqsggVSVVLPVDHVCASTfca-daqPVAVDdvhI 310 Treponema pallidum
129907    316 LDCVDSLFIGGGLAYTFLRSQ-GYSIGTSHFEeAFVPFAQALPlagsgrqVRVVLPEDHVCHAHtrpaeapLTTTSa-nI 393 Crithidia fasciculata
129927    206 LPRIDRLLIGGAMAFTFLKAL-GGEVGRSLVEeDRLDLAKDLLgraealgVRVYLPEDVVAAERieagvetRVFPAr-aI 283 Thermus thermophilus
1172459   224 ATKADSIVLGGGMCFTFLAAQ-GFSVGKSLLEtEMIETCRSLLdt---yaDVLRLPMDIVVTEKfvadsppQTVAAd-aI 298 Mycobacterium leprae
NP_600801 220 AAKADKIIVGGGMCYTFLAAQ-GHNVQQSLLQeEMKATCTDLLar---fgDKIVLPVDLVAASEfnkdaekQIVDLd-sI 294 Corynebacterium gl...
129920    205 SKIADQLIVGGGIANTFIAAQ-GHDVGKSLYEaDLVDEAKRLLt-----tCNIPVPSDVRVATEfsetapaTLKSVn-dV 277 Escherichia coli
129931    210 VSKVDHLIIGGGMANTFLAAQ-GVDVGKSLCEhELKDTVKGIFaaaektgCKIHLPSDVVVAKEfkanppiRTIPVs-dV 287 Zymomonas mobilis

Feature 1                                                                                     
1QPG      305 PAgWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKAlLDEVVKSSaa-gNTVIIGGGDTATVAKkygv- 382 baker's yeast
1VPE      287 PEgWMGLDIGPETIELFKQKLSDAKTVVWNGPMGVFEIDDFAEGTKQvALAIAALTek-gAITVVGGGDSAAAVNkfgl- 364 Thermotoga maritima
129909    306 PEgYMALDIGPKTIKIYEDVIAKCKSTIWNGPMGVFEMPCYSKGTFAvAKAMGNGTqkngLMSIIGGGDTASAAElsge- 384 Crithidia fasciculata
NP_218977 311 PMhLMGMDVGPRTLEQYRAHLKGVSSVLWNGPVGVFEFDAFAHGTRVlAQLIAEATda-gATSVVGGGDSIAAVSkfgl- 388 Treponema pallidum
129907    394 PDgYAGLDIGPLTIQSITHLVRQCSSVIWNGPLGMFEMPYYAFGTFSiARVVSQSSaakgTTSIVGGGDTASAMMksge- 472 Crithidia fasciculata
129927    284 PVpYMGLDIGPKTREAFARALEGARTVFWNGPMGVFEVPPFDEGTLA-VGQAIAALe--gAFTVVGGGDSVAAVNrlgl- 359 Thermus thermophilus
1172459   299 PDgLMGLDIGPESVKRFATLLSNASTIFWNGPMGVFEFPAYAAGTRG-VAEAIVAVtgkgAFSVVGGGDSAAAMRalslp 377 Mycobacterium leprae
NP_600801 295 PEgWMSLDIGPESVKNFGEVLSTAKTIFWNGPMGVFEFAAFSEGTRGiAQAIIDATagndAFSVVGGGDSAASVRvlgln 374 Corynebacterium gl...
129920    278 KAdEQILDIGDASAQELAEILKNAKTILWNGPVGVFEFPNFRKGTEIvANAIADSE----AFSIAGGGDTLAAIDlfgi- 352 Escherichia coli
129931    288 AAdEMILDVGPKAVAALTEVLKASKTLVWNGPLGAFEIEPFDKATVAlAKEAAALTkagsLISVAGGGDTVAALNhagv- 366 Zymomonas mobilis

Feature 1                                    
1QPG      383 tdkiSHVSTGGGASLELLEGKELPGVAFLSE 413 baker's yeast
1VPE      365 edkfSHVSTGGGASLEFLEGKELPGIASMRI 395 Thermotoga maritima
129909    385 aknmSHVSTGGGASLELLEGKSLPGVTVLTN 415 Crithidia fasciculata
NP_218977 389 asrmSHVSTGGGASLKLFEGKVLPGISCLET 419 Treponema pallidum
129907    473 aahiSHISTGGNASLELLEGKVLAAVAVLDN 503 Crithidia fasciculata
129927    360 kerfGHVSTGGGASLEFLEKGTLPGLEVLEG 390 Thermus thermophilus
1172459   378 egsvSHLSTGGGASLEYLEGKTLPGIEVLGR 408 Mycobacterium leprae
NP_600801 375 edgfSHISTGGGASLEYLEGKELPGVAILAQ 405 Corynebacterium glutamicum ATCC 13032
129920    353 adkiSYISTGGGAFLEFVEGKVLPAVAMLEE 383 Escherichia coli
129931    367 akdfSFVSTAGGAFLEWMEGKELPGVKALEA 397 Zymomonas mobilis

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