1GUZ,1I0Z,1Y6J,1LDN,1HYH,1EZ4


Conserved Protein Domain Family
LDH_like

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cd00300: LDH_like 
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L-lactate dehydrogenase-like enzymes
Members of this subfamily are tetrameric NAD-dependent 2-hydroxycarboxylate dehydrogenases including LDHs, L-2-hydroxyisocaproate dehydrogenases (L-HicDH), and LDH-like malate dehydrogenases (MDH). Dehydrogenases catalyze the conversion of carbonyl compounds to alcohols or amino acids. LDHs catalyze the last step of glycolysis in which pyruvate is converted to L-lactate. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. L-HicDH catalyzes the conversion of a variety of 2-oxo carboxylic acids with medium-sized aliphatic or aromatic side chains. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH-like subfamily is part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133418
View PSSM: cd00300
Aligned: 15 rows
Threshold Bit Score: 268.368
Threshold Setting Gi: 29826879
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ## #                    # #                                          #####
1GUZ_A         3 ITVIGAGN-VGATTAFRLAEkqlarELVLLDVVegIPQGKALDMYESGpvg-lfDTKVTGSNdYADTANSDIVIITAGLP 80  Prosthecochlori...
NP_865032      3 VSIIGAGGlVGSCAAYALQCgglarEIALLDVNveTAVGHALDLQHGSps--vaDQTIVGGG-YEHIPDSDVICITAGLR 79  Pirellula sp. 1
YP_001818184   3 LTIIGGGGrVGSNAAFALQCagivsEIQLLDANaeLAAGEALDLLHGSas--vaDQRIYAGD-YARAADSDMFVVTAGLR 79  Opitutus terrae...
Q9EVR0         7 IVVIGASN-VGSAVANKIADfqlatEVVLIDLNedKAWGEAKDSSHATsciystNIKFHLGD-YEDCKDANIIVITAGPS 84  Selenomonas rum...
NP_864108      3 ITLVGTGR-VGSAIAFALTInplasELLLLNRSreKAEGDALDLTHAAalv-dsNIKISSGE-IADSKDSDVIIFTASVP 79  Pirellula sp. 1
1I0Z_A        23 ITVVGVGQ-VGMACAISILGksladELALVDVLedKLKGEMMDLQHGSlf--lqTPKIVADKdYSVTANSKIVVVTAGVR 99  human
1Y6J_A        10 VAIIGAGF-VGASAAFTMALrqtanELVLIDVFkeKAIGEAMDINHGLpf---mGQMSLYAGdYSDVKDCDVIVVTAGAN 85  Clostridium the...
1LDN_A         9 VVVIGAGF-VGASYVFALMNqgiadEIVLIDANesKAIGDAMDFNHGKvfa-pkPVDIWHGD-YDDCRDADLVVICAGAN 85  Geobacillus ste...
1HYH_C         4 IGIIGLGN-VGAAVAHGLIAqgvadDYVFIDANeaKVKADQIDFQDAManl-eaHGNIVIND-WAALADADVVISTLGNI 80  Weissella confusa
1EZ4_A         8 VVLVGDGA-VGSSYAFAMAQqgiaeEFVIVDVVkdRTKGDALDLEDAQaf--taPKKIYSGE-YSDCKDADLVVITAGAP 83  Lactobacillus p...
Feature 1                                                   # #                      #   #       
1GUZ_A        81 RK-PGMTRe----dLLMKNAGIVKEVTDNIMKhs--kNPIIIVVSNPLDIMTHVAwvrsglpkERVIGMAgVLDAARFRS 153 Prosthecochlori...
NP_865032     80 RK-PDESRl----dLINRNTDLFVQILRDVKAagpkqSAIVLVVSNPVDILTYVAagmlglpiKQVIGLGtQLDTIRFCS 154 Pirellula sp. 1
YP_001818184  80 RK-PDESRl----dLINRNVALFDSILASIKQaglrkDALVFVVSNPVDTLTQLAvarlglpsQQVLGLGtMLDTARFRS 154 Opitutus terrae...
Q9EVR0        85 IR-PGETPdr--lkLAGTNAKIMSSVMGEIVKrt--kEAMIIMITNPLDVATYVVstqfdyprNLILGTGtMLETYRFRR 159 Selenomonas rum...
NP_864108     80 FRyPNQTRl----eMGIDNMPILRDWMPGLAKas--pNAIVVMVSNPVDALAYETirltgfdpKRVIGTGtLVDSIRYRA 153 Pirellula sp. 1
1I0Z_A       100 QQ-EGESRl----nLVQRNVNVFKFIIPQIVKys--pDCIIIVVSNPVDILTYVTwklsglpkHRVIGSGcNLDSARFRY 172 human
1Y6J_A        86 RK-PGETRl----dLAKKNVMIAKEVTQNIMKyy--nHGVILVVSNPVDIITYMIqkwsglpvGKVIGSGtVLDSIRFRY 158 Clostridium the...
1LDN_A        86 QK-PGETRl----dLVDKNIAIFRSIVESVMAsg--fQGLFLVATNPVDILTYATwkfsglphERVIGSGtILDTARFRF 158 Geobacillus ste...
1HYH_C        81 KL-QQDNPtgdrfaELKFTSSMVQSVGTNLKEsg--fHGVLVVISNPVDVITALFqhvtgfpaHKVIGTGtLLDTARMQR 157 Weissella confusa
1EZ4_A        84 QK-PGESRl----dLVNKNLNILSSIVKPVVDsg--fDGIFLVAANPVDILTYATwkfsgfpkERVIGSGtSLDSSRLRV 156 Lactobacillus p...
Feature 1                            #                                                        #  
1GUZ_A       154 FIAMELGvsmqDINACVLGGHGDAMVPVVKYTTVAGIpisdll-------paetiDKLVERTRNGGAEIVEhlkqGSAFY 226 Prosthecochlori...
NP_865032    155 LIAEELKapptQTKALILGEHGDTMVPIWSSAAIGSLplekfpg-----wtpalaNQLFTRTRGSGAEVIKr--kGGAGF 227 Pirellula sp. 1
YP_001818184 155 LIAEQLKlaptQVKALILGEHGDTMVPIWSSATAAGLplekmpg-----vtpsfqQQIFERTKTSGAEVIRr--kGGAGW 227 Opitutus terrae...
Q9EVR0       160 ILADKYQvdpkNINGYVLGEHGNAAFVAWSTTGCAGFpiddldeyf-hrteklshEAVEQELVQVAYDVINk--kGFTNT 236 Selenomonas rum...
NP_864108    154 LLSTELKihaqDIRAYILGEHGDTQFAASSIAMTGGErfyp----------sdtsRRMFEETKAMGYEVFRl--kGHTSY 221 Pirellula sp. 1
1I0Z_A       173 LMAEKLGihpsSCHGWILGEHGDSSVAVWSGVNVAGVslqelnpemgtdndsenwKEVHKMVVESAYEVIKl--kGYTNW 250 human
1Y6J_A       159 LLSEKLGvdvkNVHGYIIGEHGDSQLPLWSCTHIAGKnineyiddpkcnfteedkKKIAEDVKTAGATIIKn--kGATYY 236 Clostridium the...
1LDN_A       159 LLGEYFSvapqNVHAYIIGEHGDTELPVWSQAYIGVMpirklvesk-geeaqkdlERIFVNVRDAAYQIIEk--kGATYY 235 Geobacillus ste...
1HYH_C       158 AVGEAFDldprSVSGYNLGEHGNSQFVAWSTVRVMGQpivtlad-----agdidlAAIEEEARKGGFTVLNg--kGYTSY 230 Weissella confusa
1EZ4_A       157 ALGKQFNvdprSVDAYIMGEHGDSEFAAYSTATIGTRpvrdvake--qgvsdddlAKLEDGVRNKAYDIINl--kGATFY 232 Lactobacillus p...
Feature 1         #                                                                            
1GUZ_A       227 APASSVVEMVESIVLdRKRVLPCAVGLEgqyg-idkTFVGVPVKLGRNGVEqIYEINLDqADLDLLQKSAKIVDENCK 303 Prosthecochloris ...
NP_865032    228 AVGIAIRDVIDAVILdRKCLLPVSSVQSgcyg-ihdVALSVPTVVGRAGVVdQLEIDLWpKEVQGLRASGAALRKTLN 304 Pirellula sp. 1
YP_001818184 228 AVAITIAEVVHAIAQdKRQLLPVSSLQQgcyg-lrdVALSVPTVVGRGGVIsHVEIPLWpKEQQGLQASARALQEIWS 304 Opitutus terrae P...
Q9EVR0       237 GIAMAACRFIKSVLYdEHTILPCSAVLEgeyg-ikdVALSIPRMVCADGIMrSFEVHLTdDELEKMHKAAQSVRSALD 313 Selenomonas rumin...
NP_864108    222 GIAMATITILDSIAYdLRHTMPVSVLVDgylg-vedVCLSLPAVIGREGVTrILHPTLSeDEEAAFRNSAEVVKQTLV 298 Pirellula sp. 1
1I0Z_A       251 AIGLSVADLIESMLKnLSRIHPVSTMVKgmygieneVFLSLPCILNARGLTsVINQKLKdDEVAQLKKSADTLWDIQK 328 human
1Y6J_A       237 GIAVSINTIVETLLKnQNTIRTVGTVINgmyg-iedVAISLPSIVNSEGVQeVLQFNLTpEEEEALRFSAEQVKKVLN 313 Clostridium therm...
1LDN_A       236 GIAMGLARVTRAILHnENAILTVSAYLDglyg-erdVYIGVPAVINRNGIReVIEIELNdDEKNRFHHSAATLKSVLA 312 Geobacillus stear...
1HYH_C       231 GVATSAIRIAKAVMAdAHAELVVSNRRDdm-----gMYLSYPAIIGRDGVLaETTLDLTtDEQEKLLQSRDYIQQRFD 303 Weissella confusa
1EZ4_A       233 GIGTALMRISKAILRdENAVLPVGAYMDgqyg-lndIYIGTPAIIGGTGLKqIIESPLSaDELKKMQDSAATLKKVLN 309 Lactobacillus pen...

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