1BX4,1ESQ,1GC5,1KYH,1O14,1RK2,1UB0,1VK4,1V1A,1RFU


Conserved Protein Domain Family
ribokinase_pfkB_like

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cd00287: ribokinase_pfkB_like 
Click on image for an interactive view with Cn3D
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).
Statistics
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PSSM-Id: 238177
Aligned: 36 rows
Threshold Bit Score: 55.1788
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingsubstrate
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1BX4_A        8 ILFGMGnplldisavvdkdfldkyslkpndqi--------------------------------laedkhkelfdelvkk 55  human
1ESQ_A       31 LVHSITnn------------------------------------------------------------------------ 38  Bacillus subtilis
1GC5_A       32 GVLLAYntnidaikyldaddlekrvtekgkekvfeiienppekissieellggilrsiklgkamewfveseevrrylrew 111 Thermococcus lit...
1KYH_A       29 TALLLAgsdd---------------------------------------------------------------------- 38  Bacillus subtilis
1O14_A       13 MVLTVTlnpaldreifiedfqvnr-------------------------------------------------lyrindl 43  Thermotoga maritima
1RK2_B        6 SLVVLGsinadhilnlqsfptp----------------------------------------------------getvtg 33  Escherichia coli
1UB0_A        3 VALTIAgsdsg--------------------------------------------------------------------- 13  Thermus thermoph...
1RFU_A        6 RVLSIQshvvr--------------------------------------------------------------------- 16  sheep
ZP_00130917   2 SIFISGslaydrimnfpgkfsdhilpd------------------------------------------kihilnvcfli 39  Desulfovibrio de...
AAS08140      1 MIYTVTldpse--------------------------------------------------------------------- 11  Lactobacillus jo...
Feature 1                                                                                       
1BX4_A       56 fkveyhaggsTQNSIKVAQWMIqqphkaATFFGcigidkfgeilkrkaaeahvdahyyeqneqptgtcaa---------- 125 human
1ESQ_A       39 --------vvTNFTANGLLALGa----sPVMAYakeeva----------------------------------------- 65  Bacillus subtilis
1GC5_A      112 gwdelriggqAGIMANLLGGVYri---pTIVHVpqnpklqaelfvdgpiyvpvfegnklklvhpkdaiaeeeelihyiye 188 Thermococcus lit...
1KYH_A       39 ------xpgaALLAGLGAXRSGlg---kLVIGTsenviplivpvlpeaty------------------------------ 79  Bacillus subtilis
1O14_A       44 sktqmspggkGINVSIALSKLGv----pSVATGfvggymgkilveelrkisklittnfvyvegetrenie---------- 109 Thermotoga maritima
1RK2_B       34 nhyqvafggkGANQAVAAGRSGa----nIAFIActgddsigesvrqqlatdniditpvsvikgestgva----------- 98  Escherichia coli
1UB0_A       14 ------ggagVQADLKVFFRFGv----yGTSALtlvtaqntlgvqrvhll------------------------------ 53  Thermus thermoph...
1RFU_A       17 ------gyvgNRAATFPLQVLGf----eVDAVNsvqfsnhtgyshwkgqvln---------------------------- 58  sheep
ZP_00130917  40 drleekrggtAGNIAYSLALLGe----kPTILAtvgkdfdryeevltglglpqdgirkmddqftagay------------ 103 Desulfovibrio de...
AAS08140     12 -----svvgkGINISLILKKLGi----dSIATGivnhknveqvaeeldkaeienqfie---------------------- 60  Lactobacillus jo...
Feature 1                                                                                       
1BX4_A      126 ---------citgdnrslianlaaancykkekhldleknwmlvekARVCYIAGffltv-----------spesvLKVAHH 185 human
1ESQ_A       66 ----------------------------------------dmakiAGALVLNIgtlske----------sveamIIAGKS 95  Bacillus subtilis
1GC5_A      189 fprgfqvfdvqaprenrfianaddynarvymrrefregfeeitrnVELAIISGlqvlkeyypdgttykdvldrvESHLNI 268 Thermococcus lit...
1KYH_A       80 -----------------------------wrdgwkkaadaqleetYRAIAIGPglpq-------------tesvQQAVDH 117 Bacillus subtilis
1O14_A      110 --------iideknktitainfpgpdvtdmdvnhflrrykmtlskVDCVVISGsippgv----------negicNELVRL 171 Thermotoga maritima
1RK2_B       99 ---------lifvngegenvigihaganaalspalveaqrerianASALLMQLespl--------------esvMAAAKI 155 Escherichia coli
1UB0_A       54 ----------------------------ppevvyaqiesvaqdfpLHAAKTGAlgda--------------aivEAVAEA 91  Thermus thermoph...
1RFU_A       59 ---------------------------sdelqelydglklnhvnqYDYVLTGYtrdks-----------flamvVDIVQE 100 sheep
ZP_00130917 104 -----------ittdqsdnqitgfnpaamshpcgyqfngvtpendLAIVSPGNlq-----------------dmVELPRK 155 Desulfovibrio de...
AAS08140     61 ---------------------qtrgikitaknqqklldylkvlkaGDILVIAGsfakgi----------dpvylTDLAKV 109 Lactobacillus jo...
Feature 1                                                        #                              
1BX4_A      186 Asen--nriFTLNLSApfisqfyke----------slmkvmpyvDILFGNEteaatfareqgfetkdik-----eiakkt 248 human
1ESQ_A       96 Aneh--gvpVILDPVGagatpfrtes--------ardiirevrlAAIRGNAaeiahtvgvtdwlikgvdag--egggdii 163 Bacillus subtilis
1GC5_A      269 Lnry--nvkSHFEFAYtanrrvrea-----------lvellpkfTSVGLNEvelasimeiigdeelakevleghifsvid 335 Thermococcus lit...
1KYH_A      118 Vlta--dcpVILDAGAlakrty----------------pkregpVILTPHPgeffrxtgvpvnelqk----------kra 169 Bacillus subtilis
1O14_A      172 Arer--gvfVFVEQTPrlleriy---------------egpefpNVVKPDLrgnhasflgvdlktf-----------ddy 223 Thermotoga maritima
1RK2_B      156 Ahqn--ktiVALNPAParelpd----------------ellalvDIITPNEteaekltgirvende-----------daa 206 Escherichia coli
1UB0_A       92 Vrrfg-vrpLVVDPVMvaksgdpllakea---aaalkerlfplaDLVTPNRleaeallgrpirtlk-----------eae 156 Thermus thermoph...
1RFU_A      101 LkqqnprlvYVCDPVMgdqrngegamyvpddllpvyrekvvpvaDIITPNQfeaelltgrkihsqe-----------eal 169 sheep
ZP_00130917 156 Frsm--gmrYIFDPGQqitaltgds-----------mlecingaHMLVSNDyelemimkatg------------------ 204 Desulfovibrio de...
AAS08140    110 Adqr--aaaLVVDVPYenvldi-----------------lpmnpLLIKPNEtelkhwfekddkevtt---------keli 161 Lactobacillus jo...
Feature 1                       #                                                               
1BX4_A      249 qalpkmnskrqrIVIFTQgr---------dDTIMAte------------------------------------------- 276 human
1ESQ_A      164 rlaqqaaqklntVIAITGe-----------VDVIAdt------------------------------------------- 189 Bacillus subtilis
1GC5_A      336 amnvlmdetgieRIHFHTy----------gYYLALtqyrgeevrdallfaslaaaakamkgnlerieqirdalsvptner 405 Thermococcus lit...
1KYH_A      170 eyakewaaqlqtVIVLKGn-----------QTVIAfpd------------------------------------------ 196 Bacillus subtilis
1O14_A      224 vklaeklaeksqVSVVSYev---------kNDIVAtr------------------------------------------- 251 Thermotoga maritima
1RK2_B      207 kaaqvlhekgirTVLITLgs---------rGVWASvn------------------------------------------- 234 Escherichia coli
1UB0_A      157 eaakallalgpkAVLLKGghle----geeaVDLLAtr------------------------------------------- 189 Thermus thermoph...
1RFU_A      170 evmdmlhsmgpdTVVITSsnllsprgsdylMALGSqrtrapd-------------------------------------- 211 sheep
ZP_00130917 205 -rtkaelltmtdYIITTLge---------nGSRIDn-------------------------------------------- 230 Desulfovibrio de...
AAS08140    162 dmahslvvkgaqHVLLSLga---------nGAAIVnm------------------------------------------- 189 Lactobacillus jo...
Feature 1                                                 #  ##  #         
1BX4_A      277 ------------------------seVTAFAvldqdqkeiiDTNGAGDAFVGGFLSQLV 311 human
1ESQ_A      190 ------------------------shVYTLHnghk---lltKVTGAGSLLTSVVGAFCA 221 Bacillus subtilis
1GC5_A      406 aivleeelekeftefenglidmvdrqLAFVPtkiv--aspkSTVGIGDTISSSAFVSEF 462 Thermococcus litoralis
1KYH_A      197 ------------------------gdCWLNPtgn----galAKGGTGDTLTGXILGXLC 227 Bacillus subtilis
1O14_A      252 ------------------------egVWLIRskee--idtsHLLGAGDAYVAGMVYYFI 284 Thermotoga maritima
1RK2_B      235 ------------------------geGQRVPgfrv---qavDTIAAGDTFNGALITALL 266 Escherichia coli
1UB0_A      190 ------------------------ggVLRFSaprv---htrNTHGTGCTLSAAIAALLA 221 Thermus thermophilus
1RFU_A      212 --------------------gsvvtqRIRMEmhk----vdaVFVGTGDLFAAMLLAWTH 246 sheep
ZP_00130917 231 -------------------------gEPVMVgiarp-rqvlDPTGAGDAFRAGLLKGLT 263 Desulfovibrio desulfuricans G20
AAS08140    190 ------------------------mdALMAHapei---eevDSSGSGDALLGTFLAGML 221 Lactobacillus johnsonii NCC 533

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