1CA9,1LB6,1FLL,1RF3,1ZMS,2GKW,1D01,1F3V,1QSC,1LB5


Conserved Protein Domain Family
MATH_TRAF_C
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cd00270: MATH_TRAF_C 
Click on image for an interactive view with Cn3D
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase signaling cascades which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. There are at least six mammalian and three Drosophila proteins containing TRAF domains. The mammalian TRAFs display varying expression profiles, indicating independent and cell type-specific regulation. They display distinct, as well as overlapping functions and interactions with receptors. Most TRAFs, except TRAF1, share N-terminal homology and contain a RING domain, multiple zinc finger domains, and a TRAF domain. TRAFs form homo- and heterotrimers through its TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors.
Links
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Statistics
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PSSM-Id: 238168
Aligned: 49 rows
Threshold Bit Score: 160.466
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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TNFR bindingtrimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:TNFR binding site
Evidence:
  • Comment:TNFR = Tumor Necrosis Factor Receptor
  • Comment:Based on the binding of TRAF to peptides of TNFR-2 and CD40, members of the TNFR superfamily.
  • Structure:1CA9_A; Human TRAF2 binds TNFR-2 peptide; contacts calculated at 3.5A
  • Structure:1LB6; Human TRAF6 binds CD40 peptide; contacts calculated at 3.5A
  • Structure:1FLL; Human TRAF3 binds CD40 peptide; contacts calculated at 3.5A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               # #              #                    
1CA9_A     43 GVFIWKISDFarkrqe-avagrIPAIFSPAFYTSRYGYKMCLRIYLNGdgtgRGTHLSLFFVVMKGPNDALLRWPFNQKV 121 human
AAF60420  158 SQHTFRIPKIgltvvkatknksHRSIYSQPFYSHGYGYKMMAVAAPYGdglaFREYFSVFVCLMKGEWDDILEWPFRCDV 237 nematode
NP_727976 334 GHLIWRIKDYskkle--eskqyDTILHSAMFSNKAFGYALRLDIYLNGkgtwKGRNMIACLNVLSGEYDPLLAWPCRLQA 411 fruit fly
EAA06706   41 GHVMWRIDNFanrlq--qskelETMMKGPIFTNYPYGYMLQLEVSLYGigtwRGRNLIAGLTILPGPYDELLEWPCRLSA 118 Anopheles gambiae ...
XP_780297 267 SQLVWKIDKYaermqe-akqgkKVTIFSPPFLTSRHGYRLSVSCCLNGdgkaKSHFMSIFVCINRGEYDALLPWPFSHRI 345 purple urchin
CAB07615  263 PQLIWKIDKLqqrtne-aksgaDTTIFSVPFMSHRFGYKMMACACLFGdgssAGKSISLYVLLLKGEFDPTLEWPFHRAI 341 nematode
BAE93281  325 SQLLWKISEWsskkie-aeagkRTVLQSPLFYSARFQYKLAVLLLPNGdgkaKGTHLSIYVRLCKGEYDALLSWPYRLPI 403 Ciona intestinalis
XP_972786 266 GHLLWKIADFedkms--kakdcNTVLKSPIFYTHNYGYKIRVLVYLNGlkkwKDRYALISIHVLKGDFDALLKWPCHIEG 343 red flour beetle
AAY27978  403 GLFVWKIKNYlqrrre-aetgeMTVIHSPPFYSNFYGYKLCMRCNLNGvdfsVGRHLSVFIHFMQGEWDDILSWPFRGKI 481 Euprymna scolopes
XP_972955 253 GCYLWYFNDFknkina-mrndsRIMHYSPGFYTAANGYRLCIRLNLSPk---DPNYIAILIHVMKTEHDNALDWPFSGRL 328 red flour beetle

Feature 1                              #                   ####                             
1CA9_A    122 TLMLLDQnn--------rEHVIDAFRPDvtsssfq---rpvndmnIASGCPLFCPVSKMEaknsYVRDDAIFIKAIVD 188 human
AAF60420  238 TFSILSDdkke----lltKTIYVNEMPEiqefler----peglrnGTFGFQNFLPLAKVTe---FAADGDIFIQIKVL 304 nematode
NP_727976 412 EIIIRDQctnvadaedyvKTIFVRKKSDd---------------fIQSNQYFHIPHKVITsr-nYLRNDSMFIEVRVL 473 fruit fly
EAA06706  119 TICVRDQaanp----aeaVPIYKPIVAKvkg------------qrDKNQHYVYVPHDQLYsr-gYVKKDTLFLEVFVG 179 Anopheles gambiae st...
XP_780297 346 TFTLIDQcqdp----tarRNISYNIKPNpckenkaflgrplgernASFGTQKFVPLNMIKtl-dYIRDDTMFIKVQVD 418 purple urchin
CAB07615  342 KISLLDQnprp----edrVNITYVIDPRklkanekflarprgernAAFGSQSFCSLAILQn---YVKDDKIYVQIDVD 412 nematode
BAE93281  404 EISLIDQsqdp----rarINHTYSLRPNpckenkpflgrptsesnPSFGSQTFMPLDTLNtr-dYIRDDAIFIRVSVL 476 Ciona intestinalis
XP_972786 344 TVTLRDQen-------saKNFTKHIVAKrqsgde-----eneepqESSFSYIFIPHATLTks-hHLKNDEIFLEVKIE 408 red flour beetle
AAY27978  482 VLSVLDQnpva----dqrQHAVETLVSKpmlaafqr--ptthrnhKGFGYMEYVPLDVLDns-tYVVNDTLILKAQVF 552 Euprymna scolopes
XP_972955 329 TITLVHPlq-------pfHNIKETMMTRpeldafkk--pvqdmnpKGFGYTEFALIEELFsq-gYVENNHLLIKVQAQ 396 red flour beetle

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