1E8V,2XZI,1NSC,1NMB


Conserved Protein Domain Family
Sialidase
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cd00260: Sialidase 
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sialidases/neuraminidases
Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed beta-propeller fold. This hierarchy includes eubacterial, eukaryotic, and viral sialidases.
Links
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Statistics
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PSSM-Id: 271229
Aligned: 4 rows
Threshold Bit Score: 363.93
Created: 16-Aug-2001
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 7 residue positions
Conserved feature residue pattern:R D E R R Y EClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #                                 #                     
1E8V_A     38 NFIPAptt-----------gsgCTRIPSFDMSat-hYCYTHNVIl---------sGCRDHs-HSHQYLALGvlrttatgr 95  Newcastle disease ...
2XZI_A     15 FPLFRsanmaspdklstgigfhSFRIPAVVRTttgrILAFAEGRr---------hTNQDFg-DINLVYKRTkttann-ga 83  Aspergillus fumiga...
1NSC_B     22 ISPHRfgearg------nsaplIIREPFIACGpk-eCKHFALTHyaaqpggyyngTREDRnkLRHLISVKLgk------- 87  Influenza B virus ...
1NMB_N    104 DNAVRiged---------sdvlVTREPYVSCDpd-eCRFYALSQgttirgkhsngTIHDRsqYRDLISWPLss------- 166 Influenza A virus

Feature 1                                                                                     
1E8V_A     96 iffSTLrSISLDdt--qnRKSCSVSATP-LGCDMLCSKVTeteeed---------------ynsavpTLMAHGRLgfd-- 155 Newcastle disease ...
2XZI_A     84 spsDWEpLREVVgsgagtWGNPTPVVDDdNTIYLFLSWNGatysqngkdvlpdgtvtkkidstwegrRHLYLTESrddgn 163 Aspergillus fumiga...
1NSC_B     88 -ipTVEnSIFHMa-----AWSGSACHDG-REWTYIGVDGPds------------------------nALIKIKYG----- 131 Influenza B virus ...
1NMB_N    167 -ppTVYnSRVECi-----GWSSTSCHDG-RARMSICISGPnn------------------------nASAVIWYN----- 210 Influenza A virus

Feature 1                                                                                     
1E8V_A    156 gqYHEKDLDvttlfedwvANYPGVGGGSFId-GRVWFSVYgglkpnspsdtvqegkyviykryndtcpdeqdyqirmaks 234 Newcastle disease ...
2XZI_A    164 twSKPVDLTkeltpdgwaWDAVGPGNGIRLttGELVIPAM---------------------------------------- 203 Aspergillus fumiga...
1NSC_B    132 --EAYTDTYhsy---annILRTQESACNCIg-GDCYLMITdgsas----------------------------------- 170 Influenza B virus ...
1NMB_N    211 --RRPVTEIntw---arnILRTQESECVCQn-GVCPVVFTdgsat----------------------------------- 249 Influenza A virus

Feature 1                                                #               #                    
1E8V_A    235 sykpgrfggkriqQAILSIKVstslgEDPVLTVPpntvtlmgAEGRILTVg-TSHFLYQRGssyfsPALLYPMTVsnktA 313 Newcastle disease ...
2XZI_A    204 -------------GRNIIGRGap-gnRTWSVQRLsg----agAEGTIVQTpdGKLYRNDRPsq-kgYRMVARGTL----E 260 Aspergillus fumiga...
1NSC_B    171 ---------giskCRFLKIREg----RIIKEIFPtgrv-ehtEECTCGFAsnKTIECACRDnsytaKRPFVKLNVe--tD 234 Influenza B virus ...
1NMB_N    250 ---------gpaeTRIYYFKEg----KILKWEPLtgta-khiEECSCYGEq-AGVTCTCRDnwqgsNRPVIQIDPv--aM 312 Influenza A virus

Feature 1                                                                       #             
1E8V_A    314 TLHSPytfnaftrpgsip-----cqasarcpnscvtGVYTDPYPLifyrnhtlrGVFGTMLDSeqARLNPASAVFDs--- 385 Newcastle disease ...
2XZI_A    261 GFGAFapdag----------------------lpdpACQGSVLRYnsd---apaRTIFLNSASgtSRRAMRVRISYdad- 314 Aspergillus fumiga...
1NSC_B    235 TAEIRlmctetyldtprpddgsitgpcesngdkgrgGIKGGFVHQrma---skiGRWYSRTMSktERMGMELYVRYdgdp 311 Influenza B virus ...
1NMB_N    313 THTSQyicspvltdnprpndptvgkcndpypgnnnnGVKGFSYLDg-------gNTWLGRTISiaSRSGYEMLKVPnalt 385 Influenza A virus

Feature 1                               #                    #                        
1E8V_A    386 ----tSRSRITRVSSSst-----kaAYTTSTCFkvvktnktYCLSIAEIsntl-------fgefRIVPLLVE 441 Newcastle disease virus
2XZI_A    315 ---akKFNYGRKLEDAkvsgaghegGYSSMTKTgd-----yKIGALVESdffndgt--gknsyrAIIWRRFN 376 Aspergillus fumigatus Af293
1NSC_B    312 wtdsdALAHSGVMVSMke-----pgWYSFGFEIkdk--kcdVPCIGIEMvhdggk---ktwhsaATAIYCLM 373 Influenza B virus (STRAIN ...
1NMB_N    386 -ddrsKPTQGQTIVLNtd-----wsGYSGSFMDywaegecyRACFYVELirgrpkedkvwwtsnSIVSMCSS 451 Influenza A virus

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