1FJR


Conserved Protein Domain Family
Mth_Ecto
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cd00251: Mth_Ecto 
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The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family; Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site.
Links
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Statistics
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PSSM-Id: 119403
Aligned: 18 rows
Threshold Bit Score: -1
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:N-linked glycosylation sites [posttranslational modification site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #                                                               
1FJR_A         5 CDYFDTVDISAAQKLqNGSYLFEGLLVPAILTGEYDFRILp-DDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDng--v 81  fruit fly
Q9W0V7        30 CAFIDTANITGSYGL-DGPFVHNWTVIPRHFVAVYDFVIE--NGIRIPASRHLRACVCKTKPCVRICCLRGEIYDlekrq 106 fruit fly
Q9W0R6        29 CAYAHTVNITDGLRMkDGSYSYAGVVVPPHLMAEYSFKVI--DGVEYRAKKHLRGCVCLLKPCISFCCPENLVFDakhwn 106 fruit fly
XP_001955867  53 CKFHDTVNLTGHTRFpNGSYEYEGIIIPEHLVGNYDYVFRs-LADRVEVPNHVRGCVCKLKPCLNICCPWGQIYNsgrge 131 Drosophila anan...
XP_001352477 168 CDYFDTVNVTGSQRLvNGSYLYQGVVIPAELTAEFDYRVLp-DDSTEPVERHLRGCVCQLRPCLRLCCHHSQLMAng--q 244 Drosophila pseu...
XP_002065954  27 CNYYDTVDLTGIQPFkNGSYPYENIIIPADLIGEYDYRLTgvDDERIEVPKYIRGCACRLKSCVRFCCHHNLMFMng--e 104 Drosophila will...
XP_001971359  27 CNYYDTVDISNVERQ-NDSYLYDDIRIPASLTGDYEYKQYr-DLSREPVKKHLRACVCSLRPCIRICCPAKYILAng--k 102 Drosophila erecta
NP_788473     25 CDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLa-DGSQEPVKSHLRACICKLKPCIRFCCPRNKMMPns--r 100 fruit fly
XP_002053031   7 CDYFDTVDLTNSHKFeNGTYLYEDILIPKEKVGLYDYQILf-NGDREPVPEHTRGCACQIKSCVRFCCDPQKLLVkgegi 85  Drosophila virilis
XP_001864340  25 CDFIDSVNITDGVRDsAGNIIHNNILYKPKYFRTIDYDYEh-FSRKKFVAEYIRGCPCAVRLCIRMCCPYGTVFFqr--k 101 southern house ...
Q9W0V7        30 CAFIDTANITGSYGL-DGPFVHNWTVIPRHFVAVYDFVIE--NGIRIPASRHLRACVCKTKPCVRICCLRGEIYDlekrq 106 fruit fly
Q9W0R6        29 CAYAHTVNITDGLRMkDGSYSYAGVVVPPHLMAEYSFKVI--DGVEYRAKKHLRGCVCLLKPCISFCCPENLVFDakhwn 106 fruit fly
XP_001955867  53 CKFHDTVNLTGHTRFpNGSYEYEGIIIPEHLVGNYDYVFRs-LADRVEVPNHVRGCVCKLKPCLNICCPWGQIYNsgrge 131 Drosophila anan...
XP_001352477 168 CDYFDTVNVTGSQRLvNGSYLYQGVVIPAELTAEFDYRVLp-DDSTEPVERHLRGCVCQLRPCLRLCCHHSQLMAng--q 244 Drosophila pseu...
XP_002065954  27 CNYYDTVDLTGIQPFkNGSYPYENIIIPADLIGEYDYRLTgvDDERIEVPKYIRGCACRLKSCVRFCCHHNLMFMng--e 104 Drosophila will...
XP_001971359  27 CNYYDTVDISNVERQ-NDSYLYDDIRIPASLTGDYEYKQYr-DLSREPVKKHLRACVCSLRPCIRICCPAKYILAng--k 102 Drosophila erecta
NP_788473     25 CDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLa-DGSQEPVKSHLRACICKLKPCIRFCCPRNKMMPns--r 100 fruit fly
XP_002053031   7 CDYFDTVDLTNSHKFeNGTYLYEDILIPKEKVGLYDYQILf-NGDREPVPEHTRGCACQIKSCVRFCCDPQKLLVkgegi 85  Drosophila virilis
XP_001864340  25 CDFIDSVNITDGVRDsAGNIIHNNILYKPKYFRTIDYDYEh-FSRKKFVAEYIRGCPCAVRLCIRMCCPYGTVFFqr--k 101 southern house ...

Feature 1                         #                                                       #      
1FJR_A        82 CYDNMSdeelaeLDPFLNVTLd-----dGSVSRRhf-knELIVQWDLp-mPCDGMFYLDnre--eqDKYTLFENGTFFRh 152 fruit fly
Q9W0V7       107 CLVPVAgvsslpSHSHMEVELg-----nGSLRLVkl-qpRFSIHVET---PCEHMKAVTkgs--eyVHWTLHENGTISH- 174 fruit fly
Q9W0R6       107 CTMPHQv----rESTHVELTYa-----nRTVDQVri-rdRFVVRTEL---GCRNKFVDKkhd--nfWQWDLFENGTLRR- 170 fruit fly
XP_001955867 132 CMNDTMdhr-ewPKPVLNVTFa------ENITMEvnisqQFAVQSFR---PCAKMFSLQpei-ndfDAYLIFQNGSMFRv 200 Drosophila anan...
XP_001352477 245 CSGSIEvdl-trLNPYLNVTLd-----dGTVARRhf-qeEFIIQSDLp-iPCNDMYPLNdqe--eqDQYIVFENGSFFRp 314 Drosophila pseu...
XP_002065954 105 CIGDTDka--leYDPYLNITTs-----dGSVVEKhv-lnEFVVQRHLp-lPCSEIGTYHlddriegYEWSLFENGSFKRt 175 Drosophila will...
XP_001971359 103 CGDGLQeel-arYESYIYLTSm-----nLTIDERvp-ltEMTIIRDHf-lACDEMMHLT-------DEYDYLEDGTLRIs 167 Drosophila erecta
NP_788473    101 CSDGLTenl-krINPYLKITLe-----dGTIGKYyl-ltDMIVLRYEf-rYCEKVVSVQe------DQYKLYENGSFMIk 166 fruit fly
XP_002053031  86 CEGNINl----nYSSILNITMh-----dGAEVEKdv--mEFIVQKHLp-vPCNDHLMLNaag-nenHGWTLFENGTLVRh 152 Drosophila virilis
XP_001864340 102 CVPTESq-----LVVNVNTTLynsnrssEVVDLT-----QNQMYGFLygkPCESVYQLDpen--spEDEWIFARNGSII- 168 southern house ...
Q9W0V7       107 CLVPVAgvsslpSHSHMEVELg-----nGSLRLVkl-qpRFSIHVET---PCEHMKAVTkgs--eyVHWTLHENGTISH- 174 fruit fly
Q9W0R6       107 CTMPHQv----rESTHVELTYa-----nRTVDQVri-rdRFVVRTEL---GCRNKFVDKkhd--nfWQWDLFENGTLRR- 170 fruit fly
XP_001955867 132 CMNDTMdhr-ewPKPVLNVTFa------ENITMEvnisqQFAVQSFR---PCAKMFSLQpei-ndfDAYLIFQNGSMFRv 200 Drosophila anan...
XP_001352477 245 CSGSIEvdl-trLNPYLNVTLd-----dGTVARRhf-qeEFIIQSDLp-iPCNDMYPLNdqe--eqDQYIVFENGSFFRp 314 Drosophila pseu...
XP_002065954 105 CIGDTDka--leYDPYLNITTs-----dGSVVEKhv-lnEFVVQRHLp-lPCSEIGTYHlddriegYEWSLFENGSFKRt 175 Drosophila will...
XP_001971359 103 CGDGLQeel-arYESYIYLTSm-----nLTIDERvp-ltEMTIIRDHf-lACDEMMHLT-------DEYDYLEDGTLRIs 167 Drosophila erecta
NP_788473    101 CSDGLTenl-krINPYLKITLe-----dGTIGKYyl-ltDMIVLRYEf-rYCEKVVSVQe------DQYKLYENGSFMIk 166 fruit fly
XP_002053031  86 CEGNINl----nYSSILNITMh-----dGAEVEKdv--mEFIVQKHLp-vPCNDHLMLNaag-nenHGWTLFENGTLVRh 152 Drosophila virilis
XP_001864340 102 CVPTESq-----LVVNVNTTLynsnrssEVVDLT-----QNQMYGFLygkPCESVYQLDpen--spEDEWIFARNGSII- 168 southern house ...

Feature 1                                          
1FJR_A       153 FDr-VTLRKrEYCLQHLTFadgnatSIRIAPHNC 185 fruit fly
Q9W0V7       175 RG--HIFSK-HYCFTPLLHgn---sTWEWQPLAC 202 fruit fly
Q9W0R6       171 DN--RLWSTdEYCFSPLEHnp---eQWELTPLNC 199 fruit fly
XP_001955867 201 DDk-VFIEKnQYCLVPTFVnes-dlVYSLNPANC 232 Drosophila ananassae
XP_001352477 315 YDs-ATMSKrEYCLQAYDFregeteSFRIVAHNC 347 Drosophila pseudoobscura pseudoobscura
XP_002065954 176 FDg-VSLDKrEYCLQPVELpd---rEIRLVPHNC 205 Drosophila willistoni
XP_001971359 168 DD--RYIEKqEYCLYPYQFnsdfpkSMWIVVHRC 199 Drosophila erecta
NP_788473    167 PDvnWTLSKqWYCLHPRLEdp---nSIWILEHVY 197 fruit fly
XP_002053031 153 FDg-EHLSKrDYCLQPIHRpns-qlLYELQPHHC 184 Drosophila virilis
XP_001864340 169 YDs-RLMTRnQFCFMQNNN------SEPVIPYIC 195 southern house mosquito
Q9W0V7       175 RG--HIFSK-HYCFTPLLHgn---sTWEWQPLAC 202 fruit fly
Q9W0R6       171 DN--RLWSTdEYCFSPLEHnp---eQWELTPLNC 199 fruit fly
XP_001955867 201 DDk-VFIEKnQYCLVPTFVnes-dlVYSLNPANC 232 Drosophila ananassae
XP_001352477 315 YDs-ATMSKrEYCLQAYDFregeteSFRIVAHNC 347 Drosophila pseudoobscura pseudoobscura
XP_002065954 176 FDg-VSLDKrEYCLQPVELpd---rEIRLVPHNC 205 Drosophila willistoni
XP_001971359 168 DD--RYIEKqEYCLYPYQFnsdfpkSMWIVVHRC 199 Drosophila erecta
NP_788473    167 PDvnWTLSKqWYCLHPRLEdp---nSIWILEHVY 197 fruit fly
XP_002053031 153 FDg-EHLSKrDYCLQPIHRpns-qlLYELQPHHC 184 Drosophila virilis
XP_001864340 169 YDs-RLMTRnQFCFMQNNN------SEPVIPYIC 195 southern house mosquito

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