1KOE,1BNL,1DY1,1DY2


Conserved Protein Domain Family
Endostatin-like
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cd00247: Endostatin-like 
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Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; endostatin XVIII is monomeric and contains a heparin-binding epitope and zinc binding sites while endostatin XV is trimeric and contains neither of these sites; the generation of endostatin or endostatin-like collagen XV/XVIII fragments is catalyzed by proteolytic enzymes within the protease-sensitive hinge region of the C-terminal domain; endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies
Links
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Statistics
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PSSM-Id: 238151
Aligned: 20 rows
Threshold Bit Score: 288.848
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #        #     #        ##  #                    
1KOE         1 QPVLHLVALNTPLSGGMrgirgADFQCFQQARAVGLSGTFRAFLSSRLQDLYSIVRRADRgsVPIVNLKDEVLSPSWDSL 80   house mouse
1DY2_A       7 RPVLHLVALNTPVAGDIr----ADFQCFQQARAAGLLSTFRAFLSSHLQDLSTVVRKAERfgLPIVNLKGQVLFNNWDSI 82   house mouse
A53317    1215 KPALHLAALNMPFSGDIr----ADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERysLPIVNLKGQVLFNNWDSI 1290 human
AAD47825   462 DRVIHMIALSQPFSGNLhglrgADLQCYREARAAGYTTTFRAMLSSNVQDLVRIVHSVDFd-TTVVNVAGHHLFPSWRSF 540  Caenorhabditis e...
AAM50734    90 TPTLRVAALNEPSTGDLqgirgADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRd-LPVVNTRGDVLFNSWKGI 168  fruit fly
BAC57521   773 QKSLHMIALNFPLRGNTrgivgADARCFQQARRAGLKGTYRAFLSSRDQNVRSIVRREDRrnVPIVNIRGEQLFSSWEEL 852  Ciona intestinalis
CAF88614    67 LFQLHLVALNNPLKGDMrgirgADFQCYQQARAMGLTSTYRAFLSSHLQDLATIVRKADRtdMPVVNLRGEVLFSSWMSI 146  Tetraodon nigrov...
XP_396317  755 GTGLRMAALNEPFTGDMhgvrgADYACYRQAKRAGLRGTFRAFLSSRVQNVDSIVRLGDRd-LPIVNIKGDVLFNSWKEM 833  honey bee
XP_418896  985 KPALHLVALNLPFSGDMr----ADFHCFQQSQQAGLMTTYRAFLSSHLQDLVTVVRKTDRynLPIVNLKGETLFNNWESI 1060 chicken
EAL30849   526 TPTLRVAALNEPSVGDLqgirgADFACYRQGRRAGLLGTFKAFLSSXXXXXXXIVRPADRd-LPVVNTRGDVLFNSWKGI 604  Drosophila pseud...

Feature 1                                               ##         #                           
1KOE        81 FsgsqGQLQPGARIFSFDGRDVLRHPAWPQKSVWHGSDPSGRRlMESYCETWRTETTGATGQASSLLSGRLLEQKAAS-- 158  house mouse
1DY2_A      83 FsgdgGQFNTHIPIYSFDGRDVMTDPSWPQKVVWHGSNPHGVRlVDKYCEAWRTTDMAVTGFASPLSTGKILDQKAYS-- 160  house mouse
A53317    1291 FsghgGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRlVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYS-- 1368 human
AAD47825   541 Vn--gAQMNPHAKLFSFDRHDVLNDSRWPDKRVWHGSKDGGIR-AEQYCDGWRRADSSLTSLAGHISSNTSIFQSSGSek 617  Caenorhabditis e...
AAM50734   169 FngqgGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERsMDTYCDAWHSGDHLKGGFASNLDGHKLLEQKRQS-- 246  fruit fly
BAC57521   853 Frt-eGRMDNPNMIYSFENRQVSTDARWPVKFVWHGSYTDGRLnPMHYCASWYTDHKAVTGQASPLSTRRLLAQKPYS-- 929  Ciona intestinalis
CAF88614   147 FsgngGTFDPSVPIYSFDGRNVMTDPAWPEKLVWHGSSTVGIRlTANYCEAWRTGDMAVTGQAALLQTGRLLGQHSRS-- 224  Tetraodon nigrov...
XP_396317  834 FngngAYFSQNPRIYSFNGKNILTDFAWPEKVAWHGSHKLGDRaMDTYCDAWHSSSSDRYGLGSPLTGGRLLEQVRYS-- 911  honey bee
XP_418896 1061 FdgngGQFNIHVPIYSFDGRNVMTDPFWPQKIIWHGSTTNGIRlVSNYCEAWHTADLAAMGQASPLNTGKLLDQKTYS-- 1138 chicken
EAL30849   605 FngqgGFFSQAPRIYSFSGKNVMTDPLWPLKMVWHGSLPNGERsMDTYCDAWHSSAHDKSGYASDLAGHKLLEQKRQP-- 682  Drosophila pseud...

Feature 1                   
1KOE       159 CHNSYIVLCIENS 171  house mouse
1DY2_A     161 CANRLIVLCIENS 173  house mouse
A53317    1369 CANRLIVLCIENS 1381 human
AAD47825   618 CENKLVVLCVENM 630  Caenorhabditis elegans
AAM50734   247 CDSKLIILCVEAL 259  fruit fly
BAC57521   930 CESGFVVLCVENS 942  Ciona intestinalis
CAF88614   225 CSNHYIVLCIENT 237  Tetraodon nigroviridis
XP_396317  912 CDNKFALLCIEVT 924  honey bee
XP_418896 1139 CNNRFIVLCIENS 1151 chicken
EAL30849   683 CDGKLIVLCVEAL 695  Drosophila pseudoobscura

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