1EZU,1AZZ


Conserved Protein Domain Family
Ecotin

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cd00242: Ecotin 
Click on image for an interactive view with Cn3D
Protease Inhibitor Ecotin; homodimeric protease inhibitor
Protease Inhibitor Ecotin; homodimeric protease inhibitor which binds two chymotrypsin-like serine proteases to form a heterotetramer. Found in bacterial periplasm. Inhibits a broad range of serine proteases including collagenase, trypsin, chymotrypsin, elastase, and factor Xa but not thrombin. Inhibition mechanism involves binding at two different protease contact sites: the primary and secondary binding sites. Primary site loops of ecotin bind to the active site of target proteases in a substrate-like manner with the P1 residue in ecotin mimicking the interactions of a canonical P1 substrate residue.
Statistics
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PSSM-Id: 153074
View PSSM: cd00242
Aligned: 9 rows
Threshold Bit Score: 221.198
Threshold Setting Gi: 15387770
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:primary substrate binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1EZU_A      5 QPLEKIAPYPQAEKGMKRQVIQLTPQEDES---TLKVELLIGQTLEVDC----NLHRLGGKLENKTLEGWGFPYYVFDKV 77  Escherichia coli
1AZZ_C      5 QPLEKIAPYPQAEKGMKRQVIQLTPQEDES---TLKVELLIGQTLEVDC----NLHRLGGKLENKTLEGWGYDYYVFDKV 77  Escherichia coli
13431479   20 AKLDEKVPYPKADAGFTRQVIHLPKQDAED---AFKVEIIAGKTLEADC----NQQRLGGELEEHTLEGWGYSYYRLDKV 92  Pseudomonas aerugi...
CAC59894    2 SYCKIEAPYPEAEAGEKRIIFALDPKGDEVeqeQCMLQLIPGRVLEMSRndaaNHQTLGGSIEQHTVEGFGAKFFHVKLA 81  Leishmania major
CAC59909   12 TLADFKAPYPEPTSQQRRYVIFLDPKGDSKelnDYKVELIPGRVEKVDGt---NVYRMGGNIEERTIDGWGYPYYIVTLT 88  Leishmania major
NP_288789  25 QPLEKIAPYPQAEKGMKRQVIQLTPQEDES---TLKVELLIGQTLEVDC----NLHRLGGKLESKTLEGWGYDYYVFDKV 97  Escherichia coli O...
CAC90049   31 QPLEKIAPYPQAEKGMSRQVIFLEPQKDES---RFKVELLIGKTLNVDC----NRHMLGGNLETRTLSGWGFDYLVMDKI 103 Yersinia pestis
NP_456807  27 QPLEKIAPYPQAEKGMKRQVITLTPQQDES---TLKVELLIGQTLNVDC----NQHRLGGTLETKTLEGWGYDYYVFDNV 99  Salmonella enteric...
NP_461205  27 QPLEKIAPYPQAEKGMKRQVITLTPQQDES---TLKVELLIGQTLNVDC----NQHRLGGTLETKTLEGWGYDYYVFDNV 99  Salmonella typhimu...
Feature 1         ####                                                           
1EZU_A     78 SSPVSTMMACP--DGK-KEKKFVTAYLgdAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVV 141 Escherichia coli
1AZZ_C     78 SSPVSTMMACP--DGK-KEKKFVTAYLgdAGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVV 141 Escherichia coli
13431479   93 SGPMSTMMACP--GQK-KEQRFIPVVGe-GFLLCYNSKLPIVVYAPKDVEVRYRIWSASEKVEKAVS 155 Pseudomonas aeruginosa
CAC59894   82 KQAVSTLMYVHaeDHGeKVRKFVAMSN--APMFPYRSRYPVVVYLPKDAELRYGIWCGGQQMQAATE 146 Leishmania major
CAC59909   89 TMSGTLMMPLG--DAAlKRPRFVAMNT--KNLYRYNSRLPIVVYMPKDGELRYRIWTVKSTGSGTAK 151 Leishmania major
NP_288789  98 SSPVSTMMACP--DGK-KEKKFVTAYLgdTGMLRYNSKLPIVVYTPDNVDVKYRVWKAEEKIDNAVV 161 Escherichia coli O157:H7 EDL933
CAC90049  104 SQPASTMMACPe-DSK-PQVKFVTANLgdAAMQRYNSRLPIVVYVPQGVEVKYRIWEAGEDIRSAQV 168 Yersinia pestis
NP_456807 100 TSPVSTMMACP--EGK-KEQKFVTAWLgeDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQNAIA 163 Salmonella enterica subsp. ente...
NP_461205 100 TSPVSTMMACP--EGK-KEQKFVTAWLgeDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQNAVA 163 Salmonella typhimurium LT2

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