1G7D,1OVN


Conserved Protein Domain Family
ERp29c
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cd00238: ERp29c 
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ERp29 and ERp38, C-terminal domain; composed of the protein disulfide isomerase (PDI)-like proteins ERp29 and ERp38. ERp29 (also called ERp28) is a ubiquitous endoplasmic reticulum (ER)-resident protein expressed in high levels in secretory cells. It contains a redox inactive TRX-like domain at the N-terminus. The expression profile of ERp29 suggests a role in secretory protein production, distinct from that of PDI. It has also been identified as a member of the thyroglobulin folding complex and is essential in regulating the secretion of thyroglobulin. The Drosophila homolog, Wind, is the product of windbeutel, an essential gene in the development of dorsal-ventral patterning. Wind is required for correct targeting of Pipe, a Golgi-resident type II transmembrane protein with homology to 2-O-sulfotransferase. ERp38 is a P5-like protein, first isolated from alfalfa (the cDNA clone was named G1), which contains two redox active TRX domains at the N-terminus, like human P5. However, unlike human P5, ERp38 also contains a C-terminal domain with homology to the C-terminal domain of ERp29. It may be a glucose-regulated protein. The function of the all-helical C-terminal domain of ERp29 and ERp38 remains unclear. The C-terminal domain of Wind is thought to provide a distinct site required for interaction with its substrate, Pipe.
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Statistics
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PSSM-Id: 238146
Aligned: 34 rows
Threshold Bit Score: 68.8686
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1G7D_A      4 LPAYDALAGQFieassreaRQAILKQGQDGLsgvk-etdKKWASQYLKIMGKILd-QGEDFPASELARISKLIEnkm--- 78  Norway rat
2501210   266 IASLDELIASTs-------AADLAAAVKKAAte----lkDKYAQYYVKVADKLS--QNAEYAAKELARLEKILAkgg--s 330 Aspergillus niger
AAL50638  150 IEALDDIVARYvsg---gaIAEIAKDIKAAAgd----lkQKYAQYYVKVATKLS--ENSGYAAKELARLEKMKSkgs--l 218 Coccidioides immitis
XP_387356 267 VESLDTLVAKItgg---atIAEIAAEVKKEVegltdaaqKTYAEYYVRVFDKLS--SNNDWVSKELGRLDGILAkgg--l 339 Gibberella zeae PH-1
AAU45393  256 IAELDDLAKGFa------nKENKDEIIKKAEa-------IEGGAYYVKVMKRIIe-RGADYVEKEKARINKILEnps--m 319 Entamoeba histolytica
AAX07681  271 IAALDAIVVKYtgg---tlLSDAAAEIKKEAeslkdaaqVKYAQYYIRVFDKLS--KNDDFASKELARLDGMLKkgg--l 343 rice blast fungus
XP_655421 253 WREFDEVAKGYl-------HSNDKEKRKTKCg------eFILGSVYIDIMKKIDqlNSDDFIPSEISQLEFKLRnqlpyl 319 Entamoeba histolyt...
XP_657679 267 ILALDEIVAKYits---knFGELVDEAKKVAkt----vgGKYAEYYVKVAEKLA--QNEEYAAKELERLKKVLSkgg--s 335 Aspergillus nidula...
XP_753425 270 VAVLDEFINKYiss---rnAEELVAEVKKAAkg----lqDKYAQYYVKVAEKIS--QNEEYASKELARLKKILEkgg--s 338 Aspergillus fumiga...
BAE62934  266 IASLDELVAKYtss---qnVEELLGEVKKAAkg----lqDKYAQYYVKVAEKLS--QNKEYADKEFARVKKIIAkgg--s 334 Aspergillus oryzae

1G7D_A     79 seGKKEELQRSLNILTAF 96  Norway rat
2501210   331 apEKVDDLISRSNILRKF 348 Aspergillus niger
AAL50638  219 apEKLDDLVSRSNILRRF 236 Coccidioides immitis
XP_387356 340 apSKRDQIQQKTNVLRKF 357 Gibberella zeae PH-1
AAU45393  320 kaKKIDDFTRNLNVLEVF 337 Entamoeba histolytica
AAX07681  344 apAKLDELTRKTNVLRKF 361 rice blast fungus
XP_655421 320 spKEIDDLQRRINVLKKF 337 Entamoeba histolytica HM-1:IMSS
XP_657679 336 apEKLDDMVSRSNVLRKF 353 Aspergillus nidulans FGSC A4
XP_753425 339 apEKLDDIVSRSNILRKF 356 Aspergillus fumigatus Af293
BAE62934  335 apEKVDDLISRSNVLRQF 352 Aspergillus oryzae
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