1EJF


Conserved Protein Domain Family
p23

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cd00237: p23 
Click on image for an interactive view with Cn3D
p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.
Statistics
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PSSM-Id: 107218
View PSSM: cd00237
Aligned: 8 rows
Threshold Bit Score: 172.685
Threshold Setting Gi: 68369614
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Hsp90putative dimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Hsp90 binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                            #                             
1EJF_A         3 PASAKWYDRrdYVFIEFCVEDSkDVNVNFEksKLTFSCLggsdnFKHLNEIDLFHCIDPndSKHKRTdRSILCCLRKges 82  human
XP_001235322   5 HAKTLWYDRprYVFLEFCVEDStDVQVVIEdhRLVFSCKna-dgVEFYNEINLYARVNSkdSREKRSdRSITCFMRKwke 83  chicken
EAW60903      48 HARTLWYDRprYVFMEFCVEDStDVHVLIEdhRIVFSCKna-dgVELYNEIEFYAKVNSkdSQDKRSsRSITCFVRKwke 126 human
NP_001088493   4 QAKTLWYDRakYVFLEFCVENSrDVKVDIKkdKVIFSCLne-dnIQIYNEIQLYDKVQPldSREKRSdRSITCFLRKcke 82  African clawed ...
XP_695128     12 PAKTLWYDRkkYVTINFVVQNPkDVQVDVQdkKIILSCKdv-ddNNIYNEIEFYDRVLKadSREKVHdRTINVLIRKvke 90  zebrafish
NP_001002137   3 PAAAKWYDRrdFVFIEFLVEDSkDVKVNFDksKFGFSCLsgadnVKYSNEIDLFGSIDQdgSKHKRTdRSILCCLQKaet 82  zebrafish
NP_001080608   3 PASAKWYDRrdYVFLEFCVEDSkNVKTDFDknKLTFSCLggadsVKYLNEVELFQSIDPnaSKHKRTdRSVLCCLRKgep 82  African clawed ...
B56211         3 PASAKWYDRrdYVFIEFCVEDSkDVNVNFEksKLTFSCLggsdnFKHLNEIDLFNNIDPneSKHKRTdRSILCCLRKges 82  chicken
Feature 1            ####        #   #  #   
1EJF_A        83 gqSWPRLTKERAKLNWLSVDFNNWKDW 109 human
XP_001235322  84 kvAWPRITKENIKPAWLSVDFDNWRDW 110 chicken
EAW60903     127 kvAWPRLTKEDIKPVWLSVDFDNWRDW 153 human
NP_001088493  83 kvAWPRITKENTKPAWLFVDFDNWRDW 109 African clawed frog
XP_695128     91 nvAWPRLQKDTAKPAWLLVDFDNWRDW 117 zebrafish
NP_001002137  83 gkSWPRLTKDKAKLNWLSVDFNNWKDW 109 zebrafish
NP_001080608  83 gkSWPRLTKEKAKLNWLSVDFNNWKDW 109 African clawed frog
B56211        83 gqAWPRLTKERAKLNWLSVDFNNWKDW 109 chicken

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