1QS2,1QS1,1G24


Conserved Protein Domain Family
VIP2
?
cd00233: VIP2 
Click on image for an interactive view with Cn3D
VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of biological pathways distinct from classical A-B toxins. A novel family of insecticidal ADP-ribosyltransferses were isolated from Bacillus cereus during vegetative growth, where VIP1 likely targets insect cells and VIP2 ribosylates actin. VIP2 shares significant sequence similarity with enzymatic components of other binary toxins, Clostridium botulinum C2 toxin, C. perfringens iota toxin, C. piroforme toxin, C. piroforme toxin and C. difficile toxin.
Links
?
Statistics
?
PSSM-Id: 238144
Aligned: 13 rows
Threshold Bit Score: 171.43
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:conserved Ser-Thr-Ser motif plays both an important role in catalysis and structure
  • Structure:1QS2_A; residues involved in NAD binding
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  #            #                     
1QS2_A    203 KSLDFknd--inAEAHSWGMKNYEEWa-----kDLTDSQREALDGYARQdYKEINNYLRNQgg-------sgNEKLDAQI 268 Bacillus cereus
1QS1_A    264 KSLDFknd--inAEAHSWGMKNYEEWa-----kDLTDSQREALDGYARQdYKEINNYLRNQgg-------sgNEKLDAQI 329 Bacillus cereus
1G24_A      5 TYQEFtn----iDQAKAWGNAQYKKY-------GLSKSEKEAIVSYTKS-ASEINGKLRQNkgvi----ngfPSNLIKQV 68  Clostridium botulinum
8926247   259 SSLDFkd---dvSKGDSWGKANYNDWs-----nKLTPNELADVNDYMRGgYTAINNYLISNgpv-----nnpNPELDSKI 325 Clostridium difficile
399048     45 TFTEFtn----vEEAKKWGNAQYKKY-------GLSKPEQEAIKFYTRD-ASKINGPLRANqgne----nglPADILQKV 108 Clostridium botuli...
10176155  302 RTIDPkrf-espDEVREWLGKDDLNWi-----kGLSADENEAIREYTGTaYRKINGYLRGKrp--------gSERVKEQI 367 Bacillus halodurans
13621662   45 AYFTFsd----qKGAETLIKKRWGKGl------IYPRAEQEAMAAYTCQqAGPINTSLDKAkgel----sqlTPELRDQV 110 Streptococcus pyog...
3183651   217 QELDFy-----nKGSEAWGAENYGDYi-----sKLSHEQLGALEGYLHSdYKAINSYLRNNrv-------pnNDELNKKI 279 Clostridium botulinum
2498151    50 SFKEFtn----iDEARAWGDKQFAKY-------KLSSSEKNALTIYTRN-AARINGPLRANqgnt----nglPADIRKEV 113 Clostridium limosum
15023184  197 ARITItn----mDQANEWGSQYYDNWl-----kSLNDSERNAIRQYTGNdYKKINNYLRGVnd-------slDGIDPKII 260 Clostridium acetob...
3913025   385 KTKFLkr---miYSFSGIGAGPMIDItiardgsKYTPSQKRGIREYCGSgYTDINNLLLGRynper-ydvmsEKEIESAI 460 Enterobacteria pha...
728830    381 KTKIIrrelrgyALTAGWSLHPIVENkd---ssKYTPAQKRGIREYVGSgYVDINNALLGLynpdertsiltASDIEKAI 457 Enterobacteria pha...
119131     34 LAADVknf-tdlDEATKWGNKLIKQA-------KYSSDDKIALYEYTKD-SSKINGPLRLAggdi----nklDSTTQDKV 100 Staphylococcus aureus

Feature 1                         #                                                        ###
1QS2_A    269 KNISDALGKKP-IPENITVYRWCGMpefgyqis------------dplpslkDFEEQFl--------NTIKEDKGYMSTS 327 Bacillus cereus
1QS1_A    330 KNISDALGKKP-IPENITVYRWCGMpefgyqis------------dplpslkDFEEQFl--------NTIKEDKGYMSTS 388 Bacillus cereus
1G24_A     69 ELLDKSFNKMK-TPENIMLFRGDDPaylgtefqntll---nsngtinktafeKAKAKFl--------NKDRLEYGYISTS 136 Clostridium botulinum
8926247   326 TNIENALKREP-IPTNLTVYRRSGPqefgltltspe------ydfnklenidAFKSKWe--------GQALSYPNFISTS 390 Clostridium difficile
399048    109 KLIDQSFSKMK-MPQNIILFRGDDPaylgpefqdkil---nkdgtinktvfeQVKAKFl--------KKDRTEYGYISTS 176 Clostridium botuli...
10176155  368 KHIDEAIRKFE-LKDGIMVYRNVGRdalp--------------------sssERLKDLe--------GTIYKDDGYMSTS 418 Bacillus halodurans
13621662  111 AQLDAATHRLV-IPWNIVVYRYVYEtflrdigvsh-------adltsyyrnhQFDPHIlck---iklGTRYTKHSFMSTT 179 Streptococcus pyog...
3183651   280 ELISSALSVKP-IPQTLIAYRRVDGipfdlpsdfsfdkkengeiiadkqklnEFIDKWt--------GKEIENLSFSSTS 350 Clostridium botulinum
2498151   114 EQIDKSFTKMQ-TPENIILFRGDDPgylgpdfentil---nrdgtinkavfeQVKLRFk--------GKDRKEYGYISTS 181 Clostridium limosum
15023184  261 EDIKSGLKKAS-VPHDMKVYRGTDLnplrnl----------------idvgkDGSLDFss-----lvGKTFKDDGFMSTA 318 Clostridium acetob...
3913025   461 NNLDSAFENGDrIPEGITVYRAQSMta------------------------pIYEALVk--------NKVFYFRNFVSTS 508 Enterobacteria pha...
728830    458 DNLDSAFKNGErLPKGITLYRSQRMlp------------------------sIYEAMVk--------NRVFYFRNFVSTS 505 Enterobacteria pha...
119131    101 RRLDSSISKST-TPESVYVYRLLNLdyltsivgftne----dlyklqqtnngQYDENLvrklnnvmnSRIYREDGYSSTQ 175 Staphylococcus aureus

Feature 1                         #                                                           
1QS2_A    328 LSSerl---------aaFGSRKIILRLQVPKGs--TGAYLSa---------IGGFa------------------------ 363 Bacillus cereus
1QS1_A    389 LSSerl---------aaFGSRKIILRLQVPKGs--TGAYLSa---------IGGFa------------------------ 424 Bacillus cereus
1G24_A    137 LMNvs-----------qFAGRPIITKFKVAKGs--KAGYIDp---------ISAFa------------------------ 170 Clostridium botulinum
8926247   391 IGSvnm---------saFAKRKIVLRITIPKGs--PGAYLSa---------IPGYa------------------------ 426 Clostridium difficile
399048    177 LMSa------------qFGGRPIVTKFKVTNGs--KGGYIDp---------ISYFp------------------------ 209 Clostridium botuli...
10176155  419 VLReg-----------aFSSYDVMFEITVPGGk-gRGAYINe---------ISLFkd----------------------- 454 Bacillus halodurans
13621662  180 ALKng-----------aMTHRPVEVRICVKKGa--KAAFVEp---------YSAVp------------------------ 213 Streptococcus pyog...
3183651   351 LKStp----------ssFSKSRFIFRLRLSEGa--IGAFIYg---------FSGFq------------------------ 385 Clostridium botulinum
2498151   182 LVNgs-----------aFAGRPIITKFKVLDGs--KAGYIEp---------ISTFk------------------------ 215 Clostridium limosum
15023184  319 LVKes-----------sFDYMNVSWEINVPKGt--EAAYVSk---------ISYFp------------------------ 352 Clostridium acetob...
3913025   509 LTPiifgrfgithagigLLEPEARNELTVDKNe--EGITINpn-------eIRAYkenpeyvkvqigwaidgahkvnvvy 579 Enterobacteria pha...
728830    506 LYPnifgtw---mtdssIGVLPDEKRLSVSIDktdEGLVNSsdnlvgigwvITGAdkvnvvlp----------------- 565 Enterobacteria pha...
119131    176 LVSga-----------aVGGRPIELRLELPKGt--KAAYLNsk-------dLTAYy------------------------ 211 Staphylococcus aureus

Feature 1               #        #                            
1QS2_A    364 -------sEKEILLDKDSKYHIDKVTEViik-----gvKRYVVDATLL 399 Bacillus cereus
1QS1_A    425 -------sEKEILLDKDSKYHIDKVTEViik-----gvKRYVVDATLL 460 Bacillus cereus
1G24_A    171 -------gQLEMLLPRHSTYHIDDMRLSsd-------gKQIIITATMM 204 Clostridium botulinum
8926247   427 -------gEYEVLLNHGSKFKINKIDSYkdg-----tiTKLIVDATLI 462 Clostridium difficile
399048    210 -------gQLEVLLPRNNSYYISDMQISpn-------nRQIMITAMIF 243 Clostridium botulinum C phage
10176155  455 -------eEYEFLIKRGASFRITEVVEEg---------RMTVIRMEMI 486 Bacillus halodurans
13621662  214 -------sEVELLFPRGCQLEVVGAYVSqd-------qKKLHIEAYFK 247 Streptococcus pyogenes M1 GAS
3183651   386 -------dEQEILLNKNSTFKIFRITPItsiinrvtkmTQVVIDAEGI 426 Clostridium botulinum
2498151   216 -------gQLEVLLPRSSTYTISDMQIApn-------nKQIIITALLK 249 Clostridium limosum
15023184  353 -------dEAELLLNHGQEMIIKEATVGsd------gkLNIVLDLNLK 387 Clostridium acetobutylicum
3913025   580 pgslgiatEAEVILPRGLMVKVNKITDAsnndg-ttsnNTKLIQAEVM 626 Enterobacteria phage T6
728830    566 ggslapsnEMEVILPRGLMVKVNKITDAsyndg-tvktNNKLIQAEVM 612 Enterobacteria phage T4
119131    212 -------gQQEVLLPRGTEYAVGSVELSnd-------kKKIIITAIVF 245 Staphylococcus aureus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap