1F34


Conserved Protein Domain Family
API3

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cd00225: API3 
Click on image for an interactive view with Cn3D
Ascaris pepsin inhibitor-3 (API3); protein inhibitor that reversibly inhibits aspartic proteinase cathepsin E, and gastric enzymes pepsin and gastricsin.
Statistics
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PSSM-Id: 119406
View PSSM: cd00225
Aligned: 6 rows
Threshold Bit Score: 165.514
Threshold Setting Gi: 13096226
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
protease
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:protease binding region
Evidence:
  • Structure:1F34_A _B; pepsin inhibitor-pepsin binding regions
    View structure with Cn3D
  • Structure:1F34_A _B; N-terminal residues of inhibitor occupies and blocks the S1-S3 pepsin substrate binding pockets; pepsin's catalytic Asp residues highlighted.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####                                                                        
1F34_B      1 QFLFSMST-----GPFICTVKDNQVFVANLPWTMLEGDDiq-------vGKEFAARVEDCTNVKHDMA------------ 56  pig roundworm
AAA70419   29 GFSVAGIG-----GTAGCVVVDNKLFANSFYLRDLTTEE----------QRELAQYVEDSNQYKEEVKtsleerrkgwql 93  Dirofilaria immitis
AAA29419    3 GINVAGIG-----GNAGCVVVDNKLFANSFFLRELTTEE----------QRELAQYIEDSNRYKEEVKesleerrkgwql 67  Onchocerca volvulus
12275968   26 TIAVSGGAg----GSTGCVVTGNVLYANGFKLRELTPIE----------QQELQDYQNKVADYKATLKqavkerqeklka 91  Parelaphostrongylu...
CAD10783   26 TIAVTGGVg----GSTGCVVTGNVLYANGFRLRELNPSE----------QQELVNYEKQVADYKAAVKqalkerqeslks 91  Ostertagia ostertagi
NP_510268  11 LFPFVLPFnynngASAACIVTKNLLFSHGNLIRQLKKDEvdsfkkykkeLHVFNTKINEAFDKAEENEaknst------- 83  nematode
Feature 1                                                                                     
1F34_B     57 -------------------PTCTKPPPFCGPQDMKMFNFVGCSVLGNKLFIDQKYVRDLTAKDHAEVQTFREKIAAFEEq 117 pig roundworm
AAA70419   94 arhgekdakvlsslaekkfPKPPKKPSFCSAGDTTQYYFDGCMVQNNKIYVGRMYVRDLTSDEINQLKTFDAKMTAYQKy 173 Dirofilaria immitis
AAA29419   68 ardgkedskvlsalaekklPKPPKKPSFCSAGDTTQYYFDGCMVQNDKIYVGRAYVRDLTPDEVTQLKTFDAKMTAYQKy 147 Onchocerca volvulus
12275968   92 rla--gkkgkavetsseelPKAPKKPSFCSPDDTTQFYFDGCMVQNNRVYVGNTYARDLTPSEIEELKVFEKKQTVYQDy 169 Parelaphostrongylu...
CAD10783   92 rma--gkkekavtpkeedlPKAPQKPSFCTEDDTTQFYFDGCMVQGNKVYVGNTFARDLDQNEIQELKEFEKKQTVYQEy 169 Ostertagia ostertagi
NP_510268  84 ---------------vppmPIRPTLPSFCTGADTTMYIFGACTVQNNKVYIGTVLARELEEKEKGKLADFAKKLAAVTPg 148 nematode
Feature 1                                                      ######     
1F34_B    118 qenqpps-----------------------------sgmphgavPAGGLSPPPPPSFCTV 148 pig roundworm
AAA70419  174 lsssiqqqvdslfgdksnlfn-lftdtrhetssqpsdattisttTQAPVEPPETPHFCIA 232 Dirofilaria immitis
AAA29419  148 lsstiqkqvdslfgeksnlfnlfadtrteatsqasddatagattTQAPVEAPEPPHFCVA 207 Onchocerca volvulus
12275968  170 iqkqvqqqvsnlfgssdff-----ssffgggeakqtttteapelPEEAPEQPNVPNFCTP 224 Parelaphostrongylus tenuis
CAD10783  170 vqkqiqaqvsnlfggadffs----sffnggsekgsstttvapvlPEDAPEQPAGPNFCTR 225 Ostertagia ostertagi
NP_510268 149 --------------------------------------------TTPPTDIYKGLEFCTE 164 nematode

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