1E2A


Conserved Protein Domain Family
PTS_IIA_lac
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cd00215: PTS_IIA_lac 
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PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.
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Statistics
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PSSM-Id: 238133
Aligned: 27 rows
Threshold Bit Score: 97.6594
Created: 16-Aug-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:phosphate is received by HPr and transferred to IIB subunit
  • Citation:PMID 9261069
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              #      
1E2A_A      6 MTLLGFEIVAYAGDARSKLLEALKAAENGDFAKADSLVVEAGSCIAEAHSSQTGMLAREASGE-ELPYSVTMMHGQDHLM 84  Lactococcus lactis
NP_269996   6 PDQIIMGLILNAGDAKQHIYQALKCAKEDDYATSEKEMALADDALLEAHNLQTQFLAQEASGN-KSEITALFVHSQDHLM 84  Streptococcus pyog...
NP_466287   4 METVIFGMISQVGSARSSYLEGLRAAREGNFEEAEAKLKEGGETLANGHHEHHKLIQKEASGE-KVEIQLLLIHAEDLLI 82  Listeria monocytog...
NP_466302   4 MELASFQIISSVGAARSCIIEAMKLGRQRKFTEAYKKIDEANEFLSEGHKNHVQLIQKEADGG-DVQISILFMHAEDQFM 82  Listeria monocytog...
NP_347023   3 IEQIIMNIIIYSGDARSYMYEALSKAREGKYDEINGLIKQANDAIGKAHDIQTSMLQKEAEGE-ALKVSILFVHAQDQLM 81  Clostridium acetob...
NP_470214   3 IEKISFSLISLAGDSFSKLIEALQAAKESNTELVDQLLKEADDLMIEAHKVQTEMLIQETRGE-QASFSVLLVHAQDTLM 81  Listeria innocua
NP_469674   9 TELDSMAIILHAGNAKSCAFEALKEVKQQNIEAFTQKITEAKDEIKLAHRAHAELLRKLSSENrMREVDLLLVHAEGHLS 88  Listeria innocua
NP_346449  11 MEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEEAEDSLVEAHKIHSNLIQKEATGE-KIGFSLLFMHAEDQMA 89  Streptococcus pneu...
1945098    11 GEQISFQLILHSGNARSCIIQSLRAYKEGKKDEADALIAKAEQDLSAAHDIHFQMIQKESGGE-ATAFSLLLMHAEDHLM 89  Bacillus subtilis
4512384    11 SDQIPFMIILHSGNGRSKILQALREYREGKEAEANDLLVEAEKDLNVAHEIHFKLVQQEATGE-KTELSLLLMHAEDHLM 89  Bacillus halodurans

Feature 1                       
1E2A_A     85 TTILLKDVIHHLIELYKR 102 Lactococcus lactis
NP_269996  85 TTITEINLIKEIIDLRKE 102 Streptococcus pyogenes M1 GAS
NP_466287  83 TTETLREVVTEFVHVYKK 100 Listeria monocytogenes EGD-e
NP_466302  83 TTYTLRDVAYEMIAIWKE 100 Listeria monocytogenes EGD-e
NP_347023  82 TTISEKNLITEMIEMTKD 99  Clostridium acetobutylicum
NP_470214  82 NTILASTLIREMIEMHQE 99  Listeria innocua
NP_469674  89 STDIAVEMIRELGEIYQW 106 Listeria innocua
NP_346449  90 STEIIQLLSKEFIDLYQN 107 Streptococcus pneumoniae TIGR4
1945098    90 STLSMKELVKEMLDLFKT 107 Bacillus subtilis
4512384    90 STLTMKDLVKELLEIFKM 107 Bacillus halodurans

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