Conserved Protein Domain Family

cd00206: snake_toxin 
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Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheet; it exists as either monomers or dimers.
PSSM-Id: 119411
View PSSM: cd00206
Aligned: 31 rows
Threshold Bit Score: 46.2485
Threshold Setting Gi: 1421398
Created: 1-Nov-2000
Updated: 2-Oct-2020
Aligned Rows:
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site
  • Comment:receptor binding is achieved mainly through these 2 fingers in the toxin
  • Comment:fasciculin (FAS); acetylcholinesterase (AChE)
  • Comment:FAS is a three-fingered toxin which is a powerful reversible inhibitor of AChE
  • Structure:1FSS; FASII and AChE receptor
    View structure with Cn3D
  • Citation:PMID 8747462
  • Structure:1HOY: Bungarotoxin binds a mimotype of the nicotinic acetylcholine receptor, contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1         #         #              ##       ######                           
1FSS_B     1 TMCYSHttt---srAILTNC--GENSCYRKSRRh----pPKMVLGRGCG--CPPGDdn-leVKCCTSpDKCN 60  eastern green mamba
1KBA_A     1 RTCLISp------sSTPQTCpnGQDICFLKAQCdkfcsiRGPVIEQGCVatCPQFRsnyrsLLCCTT-DNCN 65  many-banded krait
1QKD_A     1 RICFNHqss---qpQTTKTCspGESSCYNKQWSd----fRGTIIERGCG--CPTVKpg-ikLSCCES-EVCN 61  broad-banded blue sea krait
1HOY_A     1 XVCHTTat----spISAVTCppGENLCYRKMWCdafcssRGKVVELGCAatCPSKKpy-eeVTCCST-DKCN 66  many-banded krait
128921     1 RICYIAp-------YDHKTCaaGENICYLKAWCdawcssRGKKLEFGCAatCPTVKpg-vdISCCDT-DNCN 63  shield snake
128922     1 LSCYLGy-------KHSQTCppGENVCFVKTWCdgfcntRGERIIMGCAatCPTAKsg-vhIACCST-DNCN 63  Stokes's sea snake
128955     1 LTCYKGr------dRSSETCrsEQELCCTKTWCdqwcqdRGPRLEMGCTatCPRRMpg-ldFTCCTT-DNCN 64  mulga snake
128959     1 RICLNQqqstpedqPTNGQCy-IKTDCQNKTWNt----hRGSRTDRGCG--CPKVKpg-inLRCCKT-DKCN 63  banded krait
136571     1 FTCFTTp------sDTSETCpiGNNICYEKRWSg-----HGMQIEKGCVasCPSFEshykfLLCCRI-ENCN 60  ringhals
AAF75223  22 LTCYKRy-------FDTVVCkpQETICYRYIIPat---hGNAITTRGCStsCPSGIr----LVCCST-DLCN 78  eastern brown snake

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