cd00199: WAP (This model is not part of the current CDD release)
Whey Acidic Protein (WAP) domain proteins
This family contains Whey Acidic Protein (WAP)-type four-disulfide core domains. Members of the family include whey acidic protein domains found in elafin (elastase-specific inhibitor), secretory leukocyte protease inhibitor (SLPI), waprins, and other extracellular proteinase inhibitors. These group of proteins containing 8 characteristically-spaced cysteine residues forming disulfide bonds, have been termed '4-disulfide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.
Jiyao W et al.(2023). "The conserved domain database in 2023.",