1BJT,1BGW,1AB4


Conserved Protein Domain Family
TOP4c

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cd00187: TOP4c 
Click on image for an interactive view with Cn3D
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Statistics
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PSSM-Id: 238111
Aligned: 57 rows
Threshold Bit Score: 407.338
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:Active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1BJT       280 NIRSIPNVLDGFKPGQRKVLYGCFKKNLk-SELKVAQLAPYVSECTa-YHHGEQSLAQTIIGLAQNFvgSNNIYLLLPNG 357  baker's yeast
730968     735 TERSIPNIMDGWKPGQRKVLYGCFKRNLr-NECKVAQLVGYIAEHSayHHHGESSLQQTIINMAQTFvgSNNINFLEPCG 813  Plasmodium falci...
6175065    746 NERSIPCLVDGFKPGQRKVLFACFKRADk-REVKVAQLAGAVAEISa-YHHGEQSLMGTIVNLAQDYvgSNNINLLLPIG 823  Caenorhabditis e...
418123     732 NERSIPSLVDGFKPGQRKVLFTCFKRNDk-REVKVAQLAGSVAEMSa-YHHGEQALMMTIVNLAQNFvgSNNINLLQPIG 809  human
1174740    700 LQRSIPSMVDGLKPGQRKILFVAFKKIAr-KEMKVAQLVGYVSLLSa-YHHGEQSLASAIIGMAQDYvgSNNINLLLPNG 777  thale cress
6094499    805 NLRSIPSLIDGLKPGQRKILFASFKRRLt-NEIKVSQLSGYVAEQTs-YHHGEQSLNSTIVKMAHNFvgSNNLPLLTPSG 882  Dictyostelium di...
464906     732 RIQSIPSLIDGLKPSQRKILWTLLNNMDesTEIKVSQLAGAVAHRQs-YHHGEESLVRTIIRMGQTFcgSSNLPLLQPIG 810  Caenorhabditis e...
9632132    649 LERSIPSVVDGFKPSQRKVLYCAFKRNLt-SDVKVAQFSGYVAEHSa-YHHGEVSLQGTIVNLAQDYvgSNNINWLLPEG 726  Paramecium bursa...
6094495    681 NERGIPHCFDGLKPWQRKILWAMLKRSSs-EAAKVAHLSGYISEASa-FHHGEASMQETMIKMAQNFtgGNNINLLVPEG 758  Leishmania chagasi
135994     681 NARAIPHCVDGLKPSQRKILWAMLKRHSs-EAAKVAQLSGYISEVSs-FHHGEASLQETIVKMAQNFtgGNNINLLVPEG 758  Crithidia fascic...
Feature 1                      #                                                               
1BJT       358 AFGTratGGKDAAAARYIYTELNKLTrKIFHPADDPLYKYIQEDEKTVEPeWYLPILPMILVNGAEGIGTGWSTYIPPFN 437  baker's yeast
730968     814 QFGSrkeGGKDASAARYIFTKLASSTrSIFNEYDDPILKYLNEEGQKIEPqYYIPVIPTILVNGCEGIGTGYSSFIPNYN 893  Plasmodium falci...
6175065    824 QFGTrlqGGKDSASARYIFTQLSPVTrTLFPAHDDNVLRFLYEENQRIEPeWYCPIIPMVLVNGAQGIGTGWSTNIPNYN 903  Caenorhabditis e...
418123     810 QFGTrlhGGKDAASPRYIFTMLSTLArLLFPAVDDNLLKFLYDDNQRVEPeWYIPIIPMVLINGAEGIGTGWACKLPNYD 889  human
1174740    778 QFGTrtsGGKDSASARYIFTKLSPVTrILFPKDDDLLLDYLNEDGQRIEPtWYMPIIPTVLVNGAEGIGTGWSTFIPNYN 857  thale cress
6094499    883 QFGTrlqGGSDSASARYILQLEPVGT-LPFNELDDPLLNYLEEEGESIQPdYYIPIIPMLLVNGSEGIGVGMSTSIPLFS 961  Dictyostelium di...
464906     811 QFGTrheGGNDAASARYIFTALAPTTrLLFPQADDDLLQKNVEEGMVVEP-TLCPIVPLILINGTEGIGTGWSTKIANRN 889  Caenorhabditis e...
9632132    727 QFGSrlqGGKDHASARYIFTKLNPKTrQVFVDTDDNLLKYLYDDGDKIEPeCYVPIIPSILVNGSSGIGTGSSTNIPSYN 806  Paramecium bursa...
6094495    759 QFGSrqqLGNVPEAPRYIFTKLRKVArLLFCCEDDPVLDYIVDDGETVEPnQYVPILPLLLCNGRVGIGFGFPSKMPTFH 838  Leishmania chagasi
135994     759 QFGSrqqLGNDHAAPRYIFTKLSRFArLLFPEDDDPLLDYIDEEGTMVEPnHYVPILPLLLCNGAVGIGFGFATNIPSFH 838  Crithidia fascic...
Feature 1                                                                                      
1BJT       438 PLEIIKNIRHLMNDeel----eqmHPWFRGWtgTIEEie----pLRYRMYGRIEQIgd-------nVLEITELPARTWTS 502  baker's yeast
730968     894 YKDIIDNIKRYINKepl----ipmVPWYKDFkgRIESng----kTGYETIGIINKIdn-------dTLEITELPIKKWTQ 958  Plasmodium falci...
6175065    904 PRELVKNIKRLIAGepq----kalAPWYKNFrgKIIQid----pSRFACYGEVAVLdd-------nTIEITELPIKQWTQ 968  Caenorhabditis e...
418123     890 AREIVNNVRRMLDGldp----hpmLPNYKNFkgTIQElg----qNQYAVSGEIFVVdr-------nTVEITELPVRTWTQ 954  human
1174740    858 PREIVANVRRLLNGesm----vpmDPWYRGFkgTIEKtaskeggCTYTITGLYEEVde-------tTIRITELPIRRWND 926  thale cress
6094499    962 PIDIIDQLMLRLNNqval---kklIPWYRGFkgTISPd-----rHTYRTNGVIKLVg--------rNLEITELPIGRWTS 1025 Dictyostelium di...
464906     890 PIDIIDMIRRKIDSiste---yeiPPFYEEFrgKLEVvt----pTKFISSGKIQLIrperknastfSIEIVELPIGIWTS 962  Caenorhabditis e...
9632132    807 PKDIVDNVKRLISGedl----vemKPWYKGFkgKIMEts----pGVYVTKGLYMPNg--------kTIVVSELPVGKWTH 870  Paramecium bursa...
6094495    839 PLEVSAAVRAMISGerakqvvrllVPWAVGLqgSIRRgp----eCELIAVGKYTTAra-------gRMHVTELPWMTSIE 907  Leishmania chagasi
135994     839 PLDVSAAVRAMINGesakqvvrnlVPWAVGFqgTVRRgp----eKEYIAVGKYTAHrn-------gRLHVSELPWMTSIE 907  Crithidia fascic...
Feature 1                                                                                      
1BJT       503 TIKEYLLLGLsgndki-kpwikDMEEQHDd-nIKFIITlspeema---ktrkigFYERFKLISPISLmNMVAFDpHGKIK 577  baker's yeast
730968     959 DYKEFLEELLtdekh---qlilDYIDNSShedICFTIKmdpaklq---kaeeegLEKVFKLKSTLTTtNMTLFDpNLKLQ 1032 Plasmodium falci...
6175065    969 DYKEKVLEGLmessdkkspvivDYKEYHTdttVKFVVKlspgklr--elergqdLHQVFKLQAVINTtCMVLFDaAGCLR 1046 Caenorhabditis e...
418123     955 VYKEQVLEPMlngtdktpalisDYKEYHTdttVKFVVKmteekla---qaeaagLHKVFKLQTTLTCnSMVLFDhMGCLK 1031 human
1174740    927 DYKNFLQSLKtdnga---pffqDVKAYNDeksVDFDLIlseenml---aarqegFLKKFKLTTTIATsNMHLFDkKGVIK 1000 thale cress
6094499   1026 DYKEVLNDLIdkd------vikSFQESNTensVHFTILlnnnqleqmedlteneLIKLFKLSASLNF-HLTCFDeNSKIQ 1098 Dictyostelium di...
464906     963 KYKEKLSKIVetl------pvlEFSERHTekrVHFRITldrkkssrflqksnsdLLNYFKLRTSLTE-NRVLFDrNGELK 1035 Caenorhabditis e...
9632132    871 DYKEHLDGLLekk------iisYFREKHSdtdVLFEIDfvg-----------npNIDILKLETTIRStNMHAFDpSGKIK 933  Paramecium bursa...
6094495    908 AFRTHISSLAaidr-----lvkRIADYSGanqIDIEMIvsegsm-----rtwaeCETDLGLRHRIYI-NGTVFSpDGTLI 976  Leishmania chagasi
135994     908 AFRSHISSLAssd------vvqRIADYSGanhIDIDLIvregsm-----ttwaeCETDLALSQRIYI-NGTVFSpDGTLS 975  Crithidia fascic...
Feature 1                                                                                      
1BJT       578 KYn-SVNEILSEFYYVRLEYYQKRKDHMSERLqWEVEKYSFQVKFIKMIiekeltVTNKpRNAIIQEle---nlGFPRfn 653  baker's yeast
730968    1033 RYs-TELDILKEFCYQRLKAYENRKSYLISKLeKEKRIISNKTKFILAIvnneliVNKKkKKVLVEEly---rkGYDPyk 1108 Plasmodium falci...
6175065   1047 TYt-SPEAITQEFYDSRQEKYVQRKEYLLGVLqAQSKRLTNQARFILAKinneivLENKkKAAIVDVli---kmKFDAdp 1122 Caenorhabditis e...
418123    1032 KYe-TVQDILKEFFDLRLSYYGLRKEWLVGMLgAESTKLNNQARFILEKiqgkitIENRsKKDLIQMlv---qrGYESdp 1107 human
1174740   1001 KYv-TPEQILEEFFDLRFEYYEKRKETVVKNMeIELLKLENKARFILAVlsgeiiVNKRkKADIVEDlr---qkGFTPfp 1076 thale cress
6094499   1099 KLe-SVEEIIDQFYKVRLQFYGKRREYLLKSLdNQIKRLTTTIQFLEVIasgklkIQGRsKQDLIKElesgeivGFENfg 1177 Dictyostelium di...
464906    1036 EFg-NISEIAAEFFEVRRDLYEKRLKIQKEECeAKLIYVENQLNFIEMVtngtieIRSMgRNQLEEKlq---emGFRVdp 1111 Caenorhabditis e...
9632132    934 KYd-TPLDIIRDWFEVRKDLYVKRKAYLLEDLtHRTNIAQNKHRFITMVnndeiiINKKhESVISAEle---klNFYKvd 1009 Paramecium bursa...
6094495    977 PIdgDLTPVLQWHYDRRLNLYKRRRRQIRLDE-IDLARRQSTRKFVKHFglghidLIRAtDETLIKAcv---kmGLVRvd 1052 Leishmania chagasi
135994     976 PIdaDLSPVLQWHYDRRLDLYKRRRTRQIGLLeMDLARLQSTRKFVEHFrqghidFLAAtDDTLTKTcv---klGLVRvd 1052 Crithidia fascic...
Feature 1                                                                                      
1BJT       654 kegkpyygspndeiaeqindvkgatsdeedeesshedtenvingpeelygTYEYLLGMRIWSLTKERYQKLLKQKQEKET 733  baker's yeast
730968    1109 dinkikkeeifeqelld---------------aadnpedneeiiagitvkDYDYLLSMPIFSLTLEKVEDLLTQLKEKER 1173 Plasmodium falci...
6175065   1123 vkkwkeeqklkelresgeielded-dlaavaveedeaissaakavetklsDYDYLVGMALIKLSEEEKNKLIKESEEKMA 1201 Caenorhabditis e...
418123    1108 vkawkeaqekaaeede----------------tqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDAKGR 1171 human
1174740   1077 rkaesveaaiagavdddaa-----------eepeeilvdpessssyipgsEYDYLLAMAIASLTIEKVEELLADRDKMII 1145 thale cress
6094499   1178 th---------------------------------------------ppeVYQHLFSLSILDITKERIDNLTNQLTKRKS 1212 Dictyostelium di...
464906    1112 matiaknskkvn------------------------linyedfqylnfqaNYGYLLEMPVSRLTSDEMKRLEERKSRRRT 1167 Caenorhabditis e...
9632132   1010 -------------------------------------------------gKYDYLLNMRISSLTLERATELEREAVKLNK 1040 Paramecium bursa...
6094495   1053 -------------------------------------------------dDYDYMLMNPITFYTKTSGEKLQMQIEKTEI 1083 Leishmania chagasi
135994    1053 -------------------------------------------------dGYDYILKKPITFYTKTSTEKLQADIKKTQD 1083 Crithidia fascic...
Feature 1                           
1BJT       734 ELENLLKLsaKDIWNTDLKAF 754  baker's yeast
730968    1174 ELEILRNItvETMWLKDIEKV 1194 Plasmodium falciparum (isolate K1 / Thailand)
6175065   1202 EVRVIEKKtwQDLWHEDLDNF 1222 Caenorhabditis elegans
418123    1172 EVNDLKRKspSDLWKEDLAAF 1192 human
1174740   1146 AVADMKKTtpKSLWLSDLESL 1166 thale cress
6094499   1213 EHQSISSSdpKSLWTADLQQL 1233 Dictyostelium discoideum
464906    1168 ELEAAESAdwKSVWRSELDKL 1188 Caenorhabditis elegans
9632132   1041 ELDDLSKTteTDMWNNDLQSL 1061 Paramecium bursaria Chlorella virus 1
6094495   1084 RMGVLKQTtpVKLWLRDLETI 1104 Leishmania chagasi
135994    1084 SIAVLKQTtpVKMWLTDLDKF 1104 Crithidia fasciculata

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