3ATP,1VLT,3EZH,3VA9,4LLC,5XUA,4K0D


Conserved Protein Domain Family
chemoreceptor_sensor
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cd00181: chemoreceptor_sensor 
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4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr
The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.
Links
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Statistics
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PSSM-Id: 438624
Aligned: 7 rows
Threshold Bit Score: 62.9178
Created: 1-Nov-2000
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindinghomodimer
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1VLT; Salmonella enterica aspartate receptor ligand binding domain binds aspartic acid, contacts at 4A
  • Structure:Escherichia coli serine chemoreceptor Tsr ligand binding domain binds serine, contacts at 4A
  • Comment:Arg residues from both monomers form the ligand binding pockets
  • Comment:The dimer binds two ligands
  • Citation:PMID 1660187
  • Citation:PMID 8345523
  • Citation:PMID 8831788
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #    #                                                      
3ATP_A     24 QTIRQQQSTLNGSWVALLQTRNTLNRAgirymmdqnnigsgstvaeLMESASISLKQAEKNWADYEAlprdprqstaaaa 103 Escherichia coli s...
1VLT_A     10 NELRQQQSELTSTWDLMLQTRINLSRSaarmmmdas-nqqssaktdLLQNAKTTLAQAAAHYANFKNmtplpam-aeasa 87  Salmonella typhimu...
3EZH_A      1 QGVQGSAHAINKAGSLRXQSYRLLAAVpl---------------seKDKPLIKEXEQTAFSAELTRAaer---------d 56  Escherichia coli K-12
3VA9_A     15 QQTNKALLAISAIQQAVLEAETSERGFlltg------------ietYRDSYIRARDALAARLDGLRAvladnp---eqia 79  Rhodopseudomonas p...
4LLC_A      9 SHHYATIEVSQQLEQLLGDQLVILLREt-----------------pDGQALERSQNDFRRVLEQGRAntvds-----aeq 66  Pseudomonas aerugi...
5XUA_A     10 QEPLTKERLISDWNSNVSVAVARTTAIakssda--------slvqfLAADAAATTKSTANVLKQIEPlitqp-----aer 76  Comamonas testoste...
4K0D_B     14 ELIGPRAAAAASLESAVLHVSLTARAYaltp------------epaRXDALQAALRRLEGAAARFAAlpkspeg-aalsg 80  Anaeromyxobacter d...

Feature 1                                         ## #                        
3ATP_A    104 eIKRNYDIYHNALAEl-IQLLga--------gKINEFFDQp---tQGYQDGFEKQYVAYMEQND 155 Escherichia coli str. K12 substr. ...
1VLT_A     88 nVDEKYQRYQAALAEl-IQFLdn--------gNMDAYFAQp---tQGMQNALGEALGNYARVSE 139 Salmonella typhimurium
3EZH_A     57 gQLAQLQGLQDYWRNelIPALxra------qnRETVSADVsq--fVAGLDQLVSGFDRTTEXRI 112 Escherichia coli K-12
3VA9_A     80 hIDELRLLTDMRMAQl-GRVVelgpe--rmreALDILEQAr---vDRLTERIETSLSVLTRAEQ 137 Rhodopseudomonas palustris CGA009
4LLC_A     67 aALDGVRDAYLQLQAh-TPALle--------aPXADNDGFse--aFNGLRLRLQDLQQLALAGI 119 Pseudomonas aeruginosa PAO1
5XUA_A     77 eILDKIMQVRKTYIAs-RDKVsqlkadgmaeeAESTLINSyvpaaQGYLKLLGELLNLQRASLD 139 Comamonas testosteroni CNB-2
4K0D_B     81 rILAAVPPFEKAAVAl-GTAVat-------ggDDSAIRARea-tlPPXREELLSLLRTFGALQQ 135 Anaeromyxobacter dehalogenans 2CP-C

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