1EM2,2E3M,1JSS,3FO5,1LN1,2PSO,3H3R,2E3P,1LN3


Conserved Protein Domain Family
START

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cd00177: START 
Click on image for an interactive view with Cn3D
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins
This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.
Statistics
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PSSM-Id: 176851
View PSSM: cd00177
Aligned: 92 rows
Threshold Bit Score: 76.9933
Threshold Setting Gi: 60099373
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
lipid binding
Conserved site includes 42 residues -Click on image for an interactive view with Cn3D
Feature 1:lipid binding site [chemical binding site]
Evidence:
  • Structure:2E3P_A ; human STARD11(GPBPdelta26/CERT) START domain binds C16-ceramide, contacts at 4A
    View structure with Cn3D
  • Structure:3H3R_A; human STARD11(GPBPdelta26/CERT) START domain binds an inhibitor (Hpa-14), contacts at 4A.
    View structure with Cn3D
  • Comment: (1R,3R)-N-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)alkanamide (HPA) is a synthesized analogue of ceramide. It inhibits ceramide transport by CERT.
  • Structure:1LN3_A; human STARD2(PC-TP) binds palmitoyl-linoleoyl-PtdCho, contacts at 4A.
    View structure with Cn3D
  • Structure:3FO5_A; human ACOT11/STARD14 START domain binds pentaethylene glycol and glycerol, contacts at 4A
    View structure with Cn3D
  • Comment:The specific ligand of the ACOT11/STARD14 domain is unknown; pentaethylene glycol is a remnant of the crystallography process.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ##          #                     # #           #   # 
1EM2_A      28 KEATAVVDQILAqe-------enWKFEKNney---gdTVYTIEVpf----------hgKTFILKTFLPC-PAELVYQEVI 86   human
2E3M_A      30 EMVQNHMTYSLQdvgg----danWQLVVEeg----emKVYRREVeeng-------ivlDPLKATHAVKGvTGHEVCNYFW 94   human
1LN1_A       7 SFSEEQFWEACAelqqpalagadWQLLVEts----giSIYRLLDkkt---------glYEYKVFGVLEDcSPTLLADIYM 73   human
3H3R_A      30 EMVQNHMTYSLQdvgg----danWQLVVEeg----emKVYRREVeeng-------ivlDPLKATHAVKGvTGHEVCNYFW 94   human
2E3P_A      30 EMVQNHMTYSLQdvgg----danWQLVVEeg----emKVYRREVeeng-------ivlDPLKATHAVKGvTGHEVCNYFW 94   human
1LN3_A       7 SFSEEQFWEACAelqqpalagadWQLLVEts----giSIYRLLDkkt---------glYEYKVFGVLEDcSPTLLADIYX 73   human
AAD34047    95 DQDFRSFRSECEae-------vgWNLTYSra----gvSVWVQAVemd--------rtlHKIKCRMECCDvPAETLYDVLH 155  human
BAD89977   260 NRATLELQKMATsge------pmWLRSVEtgreilnyDEYLKEFpqaqassfpgrktiEASRDAGIVFM-DAHKLAQSFM 332  thale cress
AAD40673    11 SQSIHEVLELAFstk------ipWTKLEYess--ekhIIHSYSSher---------giYLSKGVAEFNI-SPENMYELLL 72   Dictyostelium di...
ABK22705    58 ISATATGGDSKAe---------gWKVLGVged---eiEISRRWSga-----------iPMLRGRRILRGtSPSQFQAVAS 114  Sitka spruce
Feature 1           #  ##    ##                           # ####    #  # # #                   
1EM2_A      87 lqpERXVLWNk---TVTACQILQRVEd----------nTLISYDVSAGAaggvVSPRDFVNVRRIERrr-------dRYL 146  human
2E3M_A      95 n-vDVRNDWEt---TIENFHVVETLAd----------nAIIIYQTHKRVw--pASQRDVLYLSVIRKipaltendpeTWI 158  human
1LN1_A      74 d-sDYRKQWDq---YVKELYEQECNG------------ETVVYWEVKYPf--pMSNRDYVYLRQRRDldme---grkIHV 132  human
3H3R_A      95 n-vDVRNDWEt---TIENFHVVETLAd----------nAIIIYQTHKRVw--pASQRDVLYLSVIRKipaltendpeTWI 158  human
2E3P_A      95 n-vDVRNDWEt---TIENFHVVETLAd----------nAIIIYQTHKRVw--pASQRDVLYLSVIRKipaltendpeTWI 158  human
1LN3_A      74 d-sDYRKQWDq---YVKELYEQECNG------------ETVVYWEVKYPf--pXSNRDYVYLRQRRDldxe---grkIHV 132  human
AAD34047   156 d-iEYRKKWDs---NVIETFDIARLTvn---------aDVGYYSWRCPKp---LKNRDVITLRSWLPmg-------aDYI 212  human
BAD89977   333 ---DVGQWKEtfacLISKAATVDVIRqgegpsridgaiQLMFGEMQLLTp--vVPTREVYFVRSCRQls------peKWA 401  thale cress
AAD40673    73 d-iSSRSKWDf---HCREAHIIEEYDhl---------nHIIHLNFTNPL----ISNLDMNLYRSCKYdpq-----erLFV 130  Dictyostelium di...
ABK22705   115 a-iDTAKQWDp---NLAEGRYIKDLHen---------lSIIRLRFSESSkp-lFKNREFIVYERREAme------dgTLV 174  Sitka spruce
Feature 1        #                     # # ## #                       # # # # # #      # ### ##
1EM2_A     147 SSGIATShs----akPPTh-KYVRGENgPGGXIVLKsa----------snPRVCTFVWILNTDLKGrlpryLIHQSLAAT 211  human
2E3M_A     159 VCNFSVDhd----saPLNn-RCVRAKI-NVAMICQTlvsppegnqeisrdNILCKITYVANVNPGGwapasVLRAVAKRE 232  human
1LN1_A     133 ILARSTSmp----qlGERs-GVIRVKQyKQSLAIESd------------gKKGSKVFMYYFDNPGGqipswLINWAAKNG 195  human
3H3R_A     159 VCNFSVDhd----saPLNn-RCVRAKI-NVAMICQTlvsppegnqeisrdNILCKITYVANVNPGGwapasVLRAVAKRE 232  human
2E3P_A     159 VCNFSVDhd----saPLNn-RCVRAKI-NVAMICQTlvsppegnqeisrdNILCKITYVANVNPGGwapasVLRAVAKRE 232  human
1LN3_A     133 ILARSTSxp----qlGERs-GVIRVKQyKQSLAIESd------------gKKGSKVFXYYFDNPGGqipswLINWAAKNG 195  human
AAD34047   213 IMNYSVKhp----kyPPRk-DLVRAVSiQTGYLIQSt------------gPKSCVITYLAQVDPKGslpkwVVNKSSQFL 275  human
BAD89977   402 IVDVSVSved--sntEKEa-SLLKCRKlPSGCIIEDt------------sNGHSKVTWVEHLDVSAst-vqPLFRSLVNT 465  thale cress
AAD40673   131 IAMRSIEl-------EDG--DVDQFEClPNGWVIQGlr----------gqKDKCKMTFVQQCDLRDie-lqRIPGYKSFN 190  Dictyostelium di...
ABK22705   175 VAVASLPneiakgllPKSrgKFVRGLLiQSGWVIESle-----------qNNSCMVTHVVQLDPAGwlpkwVVKRLSIRL 243  Sitka spruce
Feature 1         ##  #     
1EM2_A     212 XFEFAFHLRQRIS 224  human
2E3M_A     233 YPKFLKRFTSYVQ 245  human
1LN1_A     196 VPNFLKDMARACQ 208  human
3H3R_A     233 YPKFLKRFTSYVQ 245  human
2E3P_A     233 YPKFLKRFTSYVQ 245  human
1LN3_A     196 VPNFLKDXARACQ 208  human
AAD34047   276 APKAMKKMYKACL 288  human
BAD89977   466 GLAFGARHWVATL 478  thale cress
AAD40673   191 SKERLEDFQFLTL 203  Dictyostelium discoideum
ABK22705   244 VMIIDGLSKLVDH 256  Sitka spruce

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