1FOE,1KZG,1DBH


Conserved Protein Domain Family
RhoGEF

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cd00160: RhoGEF 
Click on image for an interactive view with Cn3D
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Links
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Statistics
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PSSM-Id: 238091
Aligned: 66 rows
Threshold Bit Score: 97.3684
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
GTPase
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:GTPase interaction site [polypeptide binding site]
Evidence:
  • Structure:1FOE_A/B; Tiam1-Rac1 interaction
  • Comment:interaction with switch 1 and switch 2 regions of Rac1 is believed to mediate binding and release of GTP/GDP by Rac1
  • Structure:1KZG_A/B; DbsDH/PH-Cdc42 interaction

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #   #                                                                     
1FOE_A      12 LRKVICELLETERTYVkDLNCLXERYLKPLqketf-----ltqdeLDVLFGNLTEXVEFQV-EFLKTLEDGvrlvpdlek 85   house mouse
7506188    352 RHLAARELLDTEKSFVeGLEFLVTKYMRPLrqplect--lieaslVDKIFYRIPEILAHHQ-VLLTTLSQRidqwh---- 424  Caenorhabditis e...
7662042    174 RRYILGSVVDSEKNYVdALKRILEQYEKPLsemepk---vlserkLKTVFYRVKEILQCHS-LFQIALASRvsewd---- 245  human
7662064    514 RKHVAMTLLDTEQSYVeSLRTLMQGYMQPLkqpensv--lcdpslVDEIFDQIPELLEHHE-QFLEQVRHCmqtwh---- 586  human
435446     239 YTVVLQNILDTEKEYAkELQSLLVTYLRPLqsnnn-----lstveVTSLLGNFEEVCTFQQ-TLCQALEECskfpe---- 308  human
1708003    245 RNQVVFSMLEAEAEYVqQLHILVNNFLRPLrmaasskkppithddVSSIFLNSETIMFLHQ-IFYQGLKARissw----- 318  house mouse
7489903   1129 KQKLAQELALSEEEYVdSLTYIYNVFLQPIkksidtpnqlvsyqeNLEISSNFETLFSCHK-TFLIALKERiaewd---- 1203 Dictyostelium di...
5915668     92 RKLVLSGFLASEEIYInQLEALLLPMKPLKatattsq-pvltiqqIETIFYKIQDIYEIHK-EFYDNLCPKvqqwd---- 165  human
2960022     79 RSVVLKDLLDSERAHVaELQGLLENFLEPMqqtqi-----lsqdeYAQLMCNFVEIVRTHE-DLLIQIEECnd------- 145  fruit fly
7493290     73 IISVLEEFRDSEAAYVhDLHVAQRYYADRLsdrvkksewkdvfeiFLVLCKQASLFEIEMHkSLNDEINYIlddqdac-- 150  fission yeast
Feature 1                                                      #                               
1FOE_A      86 lekvdqfkkvlfsLGGSFLYYAd---RFKLYSAFCASHTk---VPKVLVKaktd-tafkAFLDAQnprqq---------- 148  house mouse
7506188    425 ---------kdaiLGDVLLAHFskqsMIETYISFVDNFKf--aKASIIQArq------kHAFEKYynrccrd-------h 480  Caenorhabditis e...
7662042    246 ---------svemIGDVFVASFsksmVLDAYSEYVNNFSt---AVAVLKKtca----tkPAFLEFlkqeqea-------s 302  human
7662064    587 ---------aqqkVGALLVQSFskdvLVNIYSAYIDNFLna-kDAVRVAKea------rPAFLKFleqsmre-------n 643  human
435446     309 ---------nqhkVGGCLLSLMp--hFKSMYLAYCANHPs---AVNVLTQh-------sDELEQFmenqgas-------s 360  human
1708003    319 ---------ptlvLADLFDILLp---MLNIYQEFVRNHQy---SLQILAHck-----qnRDFDKLlkqyeak------pd 372  house mouse
7489903   1204 ---------skplMSDIFMEKAg---FLKLYNYYVQNHTr---SLQVLEHciekyslfaIHLKRIesdq----------- 1257 Dictyostelium di...
5915668    166 ---------sqvtMGHLFQKLAs---QLGVYKAFVDNYKvaleTAEKCSQs-------nNQFQKIseelkvkgpkdskds 226  human
2960022    146 ------------rVGKLFLTSAp--lMKKVHQAYCAAHPk---AIVILDKy-------kDELEKYmerqgaa-------t 194  fruit fly
7493290    151 -------lkpkpsVAQLFLSWLp--kLSAVYGRYCVIQEn---IGKKVEKwmkn-ssisEYLQECdsmaki--------e 209  fission yeast
Feature 1            ##  ## ##  ##  ##  #                          #   #
1FOE_A     149 -hsstLESYLIKPIQRVLKYPLLLRELFALTdae-seEHYHLDVAIKTXNKVASHIN 203  house mouse
7506188    481 pnkldLDSLLISPIQRVPRYELIVKQMLKHTpve-heDRERLLRAQRHIHCLAVAIN 536  Caenorhabditis elegans
7662042    303 pdrttLYSLMMKPIQRFPQFILLLQDMLKNTskg-hpDRLPLQMALTELETLAEKLN 358  human
7662064    644 kekqaLSDLMIKPVQRIPRYELLVKDLLKHTped-hpDHPLLLEAQRNIKQVAERIN 699  human
435446     361 pgiliLTTNLSKPFMRLEKYVTLLQELERHMedt-hpDHQDILKAIVAFKTLMGQCQ 416  human
1708003    373 ceertLETFLTYPMFQIPRYILTLHELLAHTphe-hvERNSLDYAKSKLEELSRIMH 428  house mouse
7489903   1258 --nteLKVLLAQPLRRVSKYYLVLREILQYTrpk-hdDYDALNRVVANLKDQTDKFN 1311 Dictyostelium discoideum
5915668    227 htsvtMEALLYKPIDRVTRSTLVLHDLLKHTpvd-hpDYPLLQDALRISQNFLSSIN 282  human
2960022    195 pgllvLTTGLSKPFRRLDKYSAMLQELERHMess-hpDRGDTQRSVAVYKDIAATCS 250  fruit fly
7493290    210 snswnLDSFLVKPVQRFLKYPLLLNQLYRSAslgiisDYVLLGEACHKSEIASQRMN 266  fission yeast

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