1B09,1SAC


Conserved Protein Domain Family
PTX
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cd00152: PTX 
Click on image for an interactive view with Cn3D
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.
Links
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Statistics
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PSSM-Id: 238086
Aligned: 27 rows
Threshold Bit Score: 236.396
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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intermolecularcalcium
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:intermolecular salt bridges
Evidence:
  • Comment:interactions between subunits in pentamer
  • Structure:CRP (1B09_A)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1B09_A      1 QTDMS---RKAFVFPKESDTSYVSLKAPLtkPLKAFTVCLHFYTELssTRGYSIFSYATk--rQDNEILIFWSkd---iG 72  human
1743390    25 LQDLS---GKVFVIPMTTSTSHVKLHANVskPISAMTMCQRFNSEQ--ERGQSLFSLATq--sHDNDLLLYKRsm---gV 94  rainbow trout
1346926   216 NVDLT---NKSFMFPKESDINHVKLLPEKamSLKAFTLCMKVLLNVpeNRETILFSYRTm---FYDELNLWIErd---gR 286 African clawed frog
AAK61283  258 PGEICg-vGPTLVFPNASTRNVVFLSPGFvtALRALSFCSWVRTAS--GRLGTLLSYATe--dNDNKLVLHGRdsllpgS 332 human
1346908   172 RSWLPagcETAILFPMRSKKIFGSVHPVRpmRLESFSACIWVKATDv-LNKTILFSYGTk--rNPYEIQLYLSy----qS 244 human
O35764    279 SSAYSppdAFKVSIPIRNNYMYARVRKAVp-ELYAFTACMWLRSRSggSGQGTPFSYSVp--gQANEIVLLEAgl---eP 352 Norway rat
BAB69039   20 ATEVGl-vGKVLLFPTKTNTSFVALTPEKplSLSAFTLCMRVATELqgERETILFAYRTq---DYDELNVWREkd---gR 92  common carp
AAF21665   15 HVAGAt-gKTIMLFPQKTDTDYVTLKPTEr-VLNQITVCLKSYTEL--IKEHSLFSLAMqgsgKDNTLLIYPYpp---nN 87  Lepidobatrachus la...
1351953   212 NSAFKspdAFKVSLPFRTNYLYGKIKKTLp-ELYSFTICLWLRSSAs-PGIGTPFSYAVp--gQANEIVLIEWgn---nP 284 domestic guinea pig
2499457   217 QKDNRpgdKFQLTFPLRTNYMYAKVKKSLp-EMYAFTVCMWLKSSAt-PGVGTPFSYAVp--gQANELVLIEWgn---nP 289 human

Feature 1                                   #                #                                
1B09_A     73 YSFTVGgSEILFEvpe--vtVAPVHICTSWESASGIVEFWVDGKPRVRKs-LKKGYTVGAEASIILGQEQDSF--GGNFE 147 human
1743390    95 YRVHIRgDVLDFFslp-dskNEWISICWTWDSTTGLTQLWVNGKRSARRi-LKPDTSVTGTPSIMLVQEQDSY--GGGFD 170 rainbow trout
1346926   287 IGLYMSgDGIIFPrmk--fkSEWNHLCLTWESKYGRTEFWLNGRRSATKv-YHQKNTVRSGGIVLLGQDQDSY--GGDFD 361 African clawed frog
AAK61283  333 IHFVIGdPAFRELplqllldGQWHHICVIWTSTQGRYWLHVDRRLVATGsrFREGYEIPPGGSLVLGQEQDSV--GGGFD 410 human
1346908   245 IVFVVGgEENKLVaeamvslGRWTHLCGTWNSEEGLTSLWVNGELAATTveMATGHIVPEGGILQIGQEKNGCcvGGGFD 324 human
O35764    353 MELLINdKVAQLPlsl--kdSNWHHICIAWTTRDGLWSAYQDGELRGSGenLAAWHPIKPHGILILGQEQDTL--GGRFD 428 Norway rat
BAB69039   93 LSFYLSgSGAFFNlpa--lsTFGTHLCLTWDSETGLSAFWMNGHRSTFQl-YRKGHSIRPGGTVLLGQDPDNY--LGAFE 167 common carp
AAF21665   88 ISISIHnEDIYFKvdp--evLQWKRTCVTWDSKTGLLQLWINGKLYPRRi-TKSRSPIGPQISVILGQEQDSY--GGSFD 162 Lepidobatrachus la...
1351953   285 IELLINdKVAQLPlfv--sdGKWHHICITWTTRDGLWEAFQDGEKLGTGenLAPWHPIKSGGVLILGQEQDTV--GGRFD 360 domestic guinea pig
2499457   290 MEILINdKVAKLPfvi--ndGKWHHICVTWTTRDGVWEAYQDGTQGGSGenLAPYHPIKPQGVLVLGQEQDTL--GGGFD 365 human

Feature 1            #                                                 #
1B09_A    148 GSQSLVGDIGNVNMWDFVLSPDEINTiyl---ggPFSPNVLNWRALKYEVQG-EVFTK 201 human
1743390   171 SSQSFVGEVTDVHFWDSVISPCEIQMyme--lnkFTAGNILNWKDLQFSIEGkVFIEK 226 rainbow trout
1346926   362 KTQSFVGQIKDLKMWNKVLPLRSLKSlfk--greIGNGNIFDWSSLSYSMIG-NVAEV 416 African clawed frog
AAK61283  411 SSEAFVGSMSGLAIWDRALVPGEVANla----igKEFPTGAILTLANAALAG-GFVQG 463 human
1346908   325 ETLAFSGRLTGFNIWDSVLSNEEIREtgga-escHIRGNIVGWGVTEIQPHG-GAQYV 380 human
O35764    429 ATQAFVGDIAQFNLWDHALTPAQVLGian--ctgPLMGNVLPWEDKLVEAFG-GAKKA 483 Norway rat
BAB69039  168 VEQSFVGEITDVHMWDHVLSGSQIMAvysnqepyVPKGNVFDWNTIKYEING-SVLVV 224 common carp
AAF21665  163 INQAFVGEMSDVNVWDYVLPPENIKAyfs--ddyTLDGNFYSWDGGNYTINGlIVVLR 218 Lepidobatrachus laevis
1351953   361 ATQAFVGELSQFNIWDRVLRPQEISNian--cslNMAGNIIPWVDNNVDVFG-GASKW 415 domestic guinea pig
2499457   366 ATQAFVGELAHFNIWDRKLTPGEVYNlatc-stkALSGNVIAWAESHIEIYG-GATKW 421 human

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