1PS2,1E9T,1PCP,1PCP


Conserved Protein Domain Family
Trefoil
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cd00111: Trefoil 
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P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.
Links
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Statistics
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PSSM-Id: 238059
Aligned: 49 rows
Threshold Bit Score: 30.3898
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative ligandputative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:hydrophobic cleft may provide a binding site for protein ligands or oligosaccharide chains of the type found in mucin
  • Citation:PMID 9096235
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #                       ##     
1PS2         5 ETCt----VAPRERQNCGf--PGVTPSQCANKGCCFDdtv--rgvPWCFYPN 48   human
135040     930 QWDq---tFLESEKITCYpdaDIATQEKCTQRGCIWDtntvnpraPECYFPK 978  Oryctolagus cuniculus
7504077     14 LFQf----SIAGPRINCYp-ePSASQVLCEARGCIWNpidnidgsPSCFFKD 60   Caenorhabditis elegans
O62653     915 QWNq---vSLDSEKIDCFpdnNPENKQNCEERGCLWEpnsa-aegPRCYFPK 962  house shrew
267050     930 QWNq---iFSENERFNCYpdaDLATEQKCTQRGCVWRtgsslskaPECYFPR 978  human
AAA83174    12 LLAf----ANAAPRFDCLp-ePNGNQGACEARGCIWKeddtgknaPWCYFKD 58   Caenorhabditis elegans
O43451     953 EWSi---kIRDEEKIDCYpdeNGASAENCTARGCIWEasns-sgvPFCYFVN 1000 human
267050      61 GKCpnvlnDPVNVRINCIp-eQFPTEGICAQRGCCWRpwnd-sliPWCFFVD 110  human
O62653      46 GKCpsaenDRLDEKINCIp-dQFPTQALCAMQGCCWNprne-sptPWCSFAN 95   house shrew
O43451      88 AECp---vVNELERINCIp-dQPPTKATCDQRGCCWNpqga-vsvPWCYYSK 134  human

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