1PTX,1LQH,1SN4,1NPI,1NRA,1B3C,2SN3,1CN2,1FH3,1DQ7,1MYN,1GPS,1AYJ,1BK8,1FJN,1ICA


Conserved Protein Domain Family
Knot1
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cd00107: Knot1 
Click on image for an interactive view with Cn3D
The "knottin" fold is stable cysteine-rich scaffold, in which one disulfide bridge crosses the macrocycle made by two other disulfide bridges and the connecting backbone segments. Members include plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins, and arthropod defensins.
Links
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Statistics
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PSSM-Id: 238055
Aligned: 50 rows
Threshold Bit Score: 25.3884
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
knottin foldputative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:knottin fold
Evidence:
  • Comment:formed when one disulfide bridge crosses the macrocycle made by two other disulfide bridges and the connecting backbone segments
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #                #   #          #             # # 
1PTX_A    14 YFCGrn-----------aYCNEECTKL-KGESGYCQWasp----ygNACYCY 49  Sahara scorpion
O22869    44 TFCNpkf--------fptLCRQNCRSFkGAKGGKCVKqpk---hkhIKCFCD 84  thale cress
Q42328    43 GFCApri--------fptICYTRCRENkGAKGGRCRWgqg----snVKCLCD 82  thale cress
T14458    44 GTCAa------------nQCQAACVKRhKDGVGKCTTnpd----kkMRCICF 79  Brassica oleracea
BAA94096  45 GKCVi------------dQCKAQCAKNrKGGLARCIDtgk----ghMQCRCD 80  Indian mustard
1ICA_A     1 ATCDllsgt----ginhsACAAHCLLR-GNRGGYCNGk--------GVCVCR 39  Protophormia terraenovae
P37364     1 ATCDilsfqsqwvtpnhaGCALHCVIK-GYKGGQCKI---------TVCHCR 42  Pyrrhocoris apterus
P17722    44 VTCDllsfkg---qvndsACAANCLSL-GKAGGHCEK---------VGCICR 82  honeybee
NP_192913 46 ASCDs------------eLCASLCKKKsGGGVGTCRTkttqpskgqPECHCR 85  thale cress
P31529    55 LTCEid----------rsLCLLHCRLK-GYLRAYCSQq--------KVCRCV 87  Sarcophaga peregrina

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