2IRF,1IF1


Conserved Protein Domain Family
IRF

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cd00103: IRF 
Click on image for an interactive view with Cn3D
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.
Statistics
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PSSM-Id: 238051
Aligned: 26 rows
Threshold Bit Score: 98.1321
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA sequencemetal binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA sequence recognition sites [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #                                       
2IRF_H      5 RMRMRPWLEEQINSNTIp-GLKWLNKek----kiFQIPWMHAarhgwdvekDAPLFRNWAIHTGKHQpgi--dkpDPKTW 77  house mouse
AAD21386   10 PSSLRGWLVECCETGRHp-GMRWVDEer----tlIRIPWNHDrgsrgveeaEKNIFIDYCRSRGILHaag--relTAKEC 82  Macaca mulatta rha...
AAD21390   14 PSGLRAWLLDCCDNDKHp-GMHWLDEek----tlVRLPWNHLkgaggvsddERNMYLDYCQFKGIRQtgn--rrlSVREC 86  Macaca mulatta rha...
Q14653      5 KPRILPWLVSQLDLGQLe-GVAWVNKsr----trFRIPWKHGlrqd-aqqeDFGIFQAWAEATGAYVpgr--dkpDLPTW 76  human
AAF60037    5 GVDIRAWLVAAVESGEYr-GLVWENEdk----tvVRVPWNKVtadr-svwnSEKFFDDYCNMRGICQgek--pshYGRFR 76  Macaca mulatta rha...
AAD21389    5 DMDLKAWFIEAVESKRYp-GVEWDDEdk----tiIRVPWNRCtdsr-vdedYNKIFDDFCSARGVCQtg----shAQKFK 74  Macaca mulatta rha...
NP_570805   8 HNHLRRWIISNLEANTFpeHLCWCDEek----rsFRISWHRGm-------sGMQPVVAYCLDRDLECgr----qhNVSEC 72  Macaca mulatta rha...
AAF60039    8 YSHLRSWTLYHLNEKTYs-DLTWCDEek----ksFKLSWKKGa-------aGTPAVVAYCVERGLQVgl----dgNLLEC 71  Macaca mulatta rha...
AAD21384   14 AMGLREWIVTHANLATYs-GLFWADDektrvvlaTTTPWSVGfdy----lrDGKMYEDYCNQRNIPLpsg---rsRLGQA 85  Macaca mulatta rha...
AAC17132    7 SEWLTDFIIDALDSGRFw-GVGWLDEqk----riFTVPGRNRrerm--pegFDDFYEAFLEERRRHGlpeipeteTGLGC 79  Kaposi's sarcoma-a...
Feature 1       # ##  #                                
2IRF_H     78 KANFRCAMNSLp---DIEEVKdrsik--kgnnaFRVYRMLP 113 house mouse
AAD21386   83 KNWLSSAIRHSq---TVSDVStkdnlstpypdrCRIIRLLP 120 Macaca mulatta rhadinovirus 17577
AAD21390   87 KNWLASAIRHSq---TVEDVSteenlsapapnrCRVIRLLP 124 Macaca mulatta rhadinovirus 17577
Q14653     77 KRNFRSALNRKe---GLRLAEdrskd---phdpHKIYEFVN 111 human
AAF60037   77 KMRFLYDMRHHk---SIRELKfinkaygrpgarYRLFRLLP 114 Macaca mulatta rhadinovirus 26-95
AAD21389   75 KIRMLYAVRSHr---YLRELTppskaggvsgerYRLFQLLP 112 Macaca mulatta rhadinovirus 17577
NP_570805  73 RKRLLRVLRENa---GFEQDDaratt--trfggERFFYLRP 108 Macaca mulatta rhadinovirus
AAF60039   72 KRRFLRGLRENa---GFQEVEhgvvr--thgggWTAFRVKP 107 Macaca mulatta rhadinovirus 26-95
AAD21384   86 KARLLGAIRKSa--yFIEEKDvlrrs---fsfaNVVFRLRS 121 Macaca mulatta rhadinovirus 17577
AAC17132   80 FGRLLRTANRArqerPFTIYKgkm------klnRWIMTPRP 114 Kaposi's sarcoma-associated herpesvirus - Human herpesvir...

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