1WQJ,1EFE


Conserved Protein Domain Family
IlGF_like
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cd00101: IlGF_like 
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Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related peptides 1 to 5 (MIP), and C. elegans insulin-like peptides. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds.
Links
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Statistics
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PSSM-Id: 238049
Aligned: 131 rows
Threshold Bit Score: 29.5204
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WQJ_I         5 LCGAELVDALqFVCGDRGFYfnkptgyg---------------------------------------------------- 32  human
NP_002186     30 GCGPRFGKHLlSYCPMPEKTftttpggwllesgrpkemvstsnnkdgqalgtts-------------------------- 83  human
AAD40956      32 LCGRDLLVEViKLCGQNDWSrfsmeeqspmtelvpqytrkvktfnphrsssswgrftnpgvsqkkathtwesqsl----- 106 Norway rat
NP_038782     32 LCGRHLLIEViKLCGQSDWSrfemeeqspmtqffphysrkgkafnphpsssawrrftnpvpagvsqkkgthtwepqs--- 108 house mouse
NP_072105     32 LCGRDLLVEViKLCGQNDWSrfsmeeqspmtelvpqytrkvktfnphrsssswgrftnpgvsqkkathtwesqsl----- 106 Norway rat
CAC42282      34 LCGSRLTTTLlAVCRNQLCTgltafkrsadqsyap--------------------------------------------- 68  nematode
CAD13336      32 LCGRYLVKEIeKLCGHANWSqfrfeeetpfsrliaqasekveayspyqfespqtaspargrgtnpvstsweeavnswemq 111 human
XP_533544    448 LCGRHLLKEIiKLCGNVNWSyfeeetpvpplfpqdneietfipdrsessqstfpawargtspvstsayeeeavsslemps 527 dog
AAI09722      29 LCGQHLLHEIvKLCGDVNWShvekekpftqllsqasekvesfipdrsessqttfpvwrratnpvptsasqeeainnmkmq 108 cattle
XP_001082439  32 LCGRYLVKEIeKLCGHANWSqfhfeeetpfprliaqasekveafspyrfespqtafpargrgtnpvstsasweeavnnwe 111 rhesus monkey

1WQJ_I        33 ------------------------------------------------------sssrrapqTGIVDECCFRSCDLRRLE 58  human
NP_002186     84 ----------------------------efipnlspelkkplsegqpslkkiilsrkkrsgrHRFDPFCCEVICDDGTSV 135 human
AAD40956     107 -------pnyqlkkeellpktgvhsyhggkpyvksvkfqkkntdkmstfsglfwgnhpqrkrRGFADKCCAIGCSKEELA 179 Norway rat
NP_038782    109 ------lpdyqfektellpkarvfsyhsgkpyvksvqlqkkstnkmntfrslfwgnhsqrkrRGFADKCCVIGCTKEEMA 182 house mouse
NP_072105    107 -------pnyqlkkeellpktgvhsyhggkpyvksvkfqkkntdkmstfsglfwgnhpqrkrRGFADKCCAIGCSKEELA 179 Norway rat
CAC42282      69 ------------------------------------------------ttrdlfhihhqqkrGGIATECCEKRCSFAYLK 100 nematode
CAD13336     112 --slpeykdkkgysplgktrefssshninvyihenakfqkkrrnkiktlsnlfwghhpqrkrRGYSEKCCLTGCTKEELS 189 human
XP_533544    528 ---lpeyrykranlppdktrefsssqdinqyiheisefqkkstnkiktlsnmfwgnhpqrkrRGYSEKCCLTGCTVEELS 604 dog
AAI09722     109 s-lpeyqykkanlpfktrqeessssqdispyiheiiefqkkntnkiktlsnlfwgnhpqrkrRGYSEKCCQKGCTKEELI 187 cattle
XP_001082439 112 mqslpeyqdkkayspldkerefssshninlyihenakfqkksrnkiktlsnlfwgnhpqrkrRGYSEKCCLTGCTKEELS 191 rhesus monkey

1WQJ_I        59 mYC 61  human
NP_002186    136 kLC 138 human
AAD40956     180 vAC 182 Norway rat
NP_038782    183 vAC 185 house mouse
NP_072105    180 vAC 182 Norway rat
CAC42282     101 tFC 103 nematode
CAD13336     190 iAC 192 human
XP_533544    605 iAC 607 dog
AAI09722     188 iAC 190 cattle
XP_001082439 192 iAC 194 rhesus monkey
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