1QSP,2A0B,1I5N


Conserved Protein Domain Family
HPT
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cd00088: HPT 
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Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is modulated by phosphorylation and dephosphorylation of a conserved aspartic acid residue; two-component proteins are abundant in most eubacteria; In E. coli there are 62 two-component proteins involved in a variety of processes such as chemotaxis, osmoregulation, metabolism and transport 1; also present in both Gram positive and Gram negative pathogenic bacteria where they regulate basic housekeeping functions and control expression of toxins and other proteins important for pathogenesis; in archaea and eukaryotes, two-component pathways constitute a very small number of all signaling systems; in fungi they mediate environmental stress responses and, in pathogenic yeast, hyphal development. In Dictyostelium and in plants, they are involved in important processes such as osmoregulation, cell growth, and differentiation; to date two-component proteins have not been identified in animals; in most prokaryotic systems, the output response is effected directly by the RR, which functions as a transcription factor while in eukaryotic systems, two-component proteins are found at the beginning of signaling pathways where they interface with more conventional eukaryotic signaling strategies such as MAP kinase and cyclic nucleotide cascades
Links
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Statistics
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PSSM-Id: 238041
Aligned: 87 rows
Threshold Bit Score: 40.8278
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteputative
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:part of the phosphorelay system (histidine to aspartate phosphoryl transfer)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                                         
1QSP_A      26 SKGLIIQFIDQAQTTFAQMQRQLdg--eKNLTELDNLGHFLKGSSAAlGLQRIAWVCERIQNlgrkmehffpnktelvnt 103  baker's yeast
BAA82874    43 VAEVVTLFCDDADRIISELAALLdq-piVDFDKVDAYVHQLKGSSASvGAQKVKFTCMQFRQlcqdknrdg--------- 112  corn
NP_486915 1722 FAELINCYLTESPKLIQNIDVAIn---tKDTQGIWKTAHKFKSSSGSvGAVFLAQLCKLLETkgrnnnl----------- 1787 Nostoc sp. PCC 7120
7429077    920 LREIIDIYCQTAPELLQRIKLAIa---nQDWGNLSSAAHTLGSSSANlGAVLLAQQAKTLENltrqrdsr---------- 986  Synechocystis sp.
NP_462726  824 LRQWVALFKDSALPLVEEIEAARa---mNDDVNIKRLAHKLKSGCASlGMTQATEACRELELqplsd------------- 887  Salmonella typhi...
P39453     825 IHEWLVLFTQHALPLLDEIDIARa---sQDSEKIKRAAHQLKSSCSSlGMHIASQLCAQLEQqplsa------------- 888  Escherichia coli
NP_189581   44 VSEVLSLFFEDCVKLISNMARALdttgtVDFSQVGASVHQLKGSSSSvGAKRVKTLCVSFKEccea-------------- 109  thale cress
7470852   1366 FGEMVACYCQESQKLIEELVQGLe---vDDFAVIRRTAHSLKSSSASlGAQQLSTFCQQLEKnagsgnl----------- 1431 Synechocystis sp.
AAK38843    42 VIEVVSLFFEDSEKLLNDLTRALdq-qdVDFKKVDACVHQLKGSSSSiGAERVKNACIAFRNfcde-------------- 106  Madagascar periw...
BAA84993    39 VSEVVTLFCQDGERIIEELAKLLek-pnVDFDRVDAFVHQLKGSSANiGAQKVKNTCIQFREfcqq-------------- 103  corn

Feature 1                                                      
1QSP_A     104 lsdksiinginideddeeikiqvddkdensiylILIAKALNQSRLEFK 151  baker's yeast
BAA82874   113 ------------------------cimalavvrNEFYDLRNKFQTMLQ 136  corn
NP_486915 1788 --------------------------egcvelgSQLRQEYELVQTALH 1809 Nostoc sp. PCC 7120
7429077    987 --------------------------amdpghfPTLAASYERVQGELK 1008 Synechocystis sp.
NP_462726  888 -----------------------------idikTIVTQGVTALDAWIA 906  Salmonella typhimurium LT2
P39453     889 -----------------------------plphEEITRSVAALEAWLH 907  Escherichia coli
NP_189581  110 ------------------------------knyEGCVRCLQQVDIEYK 127  thale cress
7470852   1432 ---------------------------glgsppQLVDRCRQLHIAVVE 1452 Synechocystis sp.
AAK38843   107 ------------------------------lniDACLRCLQHVKQEYL 124  Madagascar periwinkle
BAA84993   104 ------------------------------ksrDGCLKVLETMRINFY 121  corn

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