1JOY


Conserved Protein Domain Family
HisKA

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cd00082: HisKA 
Click on image for an interactive view with Cn3D
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Statistics
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PSSM-Id: 119399
View PSSM: cd00082
Aligned: 463 rows
Threshold Bit Score: 31.414
Threshold Setting Gi: 3122314
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
phosphorylationdimer interface
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:site of trans-autophosphorylation and phosphate transfer reaction
  • Comment:phosphate is transfered to Asp of a downstream response regulator

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                                                       
1JOY_A      9 ADDRTLLMAGVSHDLRTPLTRIRLATEMMSeq---------dGYLAESINKDIEECNAIIEQFIDYLX 67  Escherichia coli
NP_253573 241 YQRLQQFSADLAHEIRTPIGSLMGHGQVALrqprs---neeyQALIASNQEELERIARMVESILFLAR 305 Pseudomonas aeruginosa
AAG09630  239 VQQLSQFSDDLAHELRAPLTNLMGKAQLTLsrqrp---pdeyKAVLESNTEELERLARIVSDMLFLAQ 303 Pseudomonas fluorescens
AAF18102  281 LATLGRFSAQMAHDLKNPIAAMKGAAQYLKeehargrswdgqGEFLDLLLEQVERLDRVVDTYQRLAR 348 Myxococcus xanthus
P76339    233 FERLSQFADDLAHELRTPINALLGQNQVTLsqtrs---iaeyQKTIAGNIEELENISRLTENILFLAR 297 Escherichia coli
NP_284516 310 LAALGQLTANLAHEIRNPMSAIRHANDLLRenmeagaadpfnAKLCKIIDGNVCRIDKMLEDISSLNK 377 Neisseria meningitidis Z2491
2443475   378 LASMGRLVASVAHQIRNPLAAISQAAELLDdpg------eggEPLRPEGRGVETRLLRIIRDNVRRLD 439 Ralstonia solanacearum
AAC82507  310 LAALGQLTANLAHEIRNPMSAIRHADGGTLfvdev--adlplSMQVKLLRAIQEKAVRRIGDATEQPV 375 Neisseria gonorrhoeae
O31396    240 FVRLSQFSSNLAHDMRTPLTNLLAEAQVALskprt---adeyRDVIESSIDEYQRLSRMIEDMLFLAR 304 Burkholderia pseudomallei 112
Q44007    233 YQKLSRFSADLAHDLRTPLNNLIGHAEVALsrdrt---gpeyVALVEESLVEYQRLARMIDAMLFLAR 297 Ralstonia pickettii 12J

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