1GKY,1LVG,1S4Q


Conserved Protein Domain Family
GMPK
?
cd00071: GMPK 
Click on image for an interactive view with Cn3D
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.
Links
?
Statistics
?
PSSM-Id: 238026
Aligned: 57 rows
Threshold Bit Score: 103.381
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
catalytic siteG-X2-G-X-G-K
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:catalytic mechanism is similar to adenylate cyclase
  • Comment:predicted to bind ATP where SO4 binds through structural homology
  • Comment:assumes an intermediate conformation upon initial binding to GMP
  • Comment:conformational change is achieved through secondary ATP binding
  • Structure:1GKY, binds GMP and sulfate ion (SO4)
  • Citation:PMID 1314905
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          #     #                #      #  #        #                      #         
1GKY        4 PIVISGPSGTGKSTLLKKLfaeypdsFGFSVSSTTRTPRagEVNGKDYNFvsvdefksmiknneFIEWAQFs-------- 75  baker's yeast
AAG12252  138 PVVITGPSGVGKGTLINKLmkdfpstFGFSVSHTTRAPRekEVDGVHYHFsersimekdirerkXLESASVh-------- 209 trumpet lily
T46191    140 PIVISGPSGVGKGTLISMLmkefpsmFGFSVSHTTRAPRcmEKNGVHYHFtdktvmekeikdgkFLEFASVh-------- 211 thale cress
XP_326155  11 PVVISGPSGVGKGTLFKLLferhpdtFTLSVSHTTRGPRpgEKDGVDYHYvtkeafeelkakggFVESAQFg-------- 82  Neurospora crassa
NP_704827   6 PLVICGPSGVGKGTLIKKLlnefpnyFYFSVSCTTRKKRekEKEGVDYYFidktifedklknedFLEYDNYa-------- 77  Plasmodium falcipa...
EAA75412   11 PIIISGPSGVGKRTLLTKLceshhetFSIAVSHTTRPPRpdEIQDVHYHFttetefqhlyaqgaFVECTVYn-------- 82  Gibberella zeae PH-1
NP_586736  39 HLVLTGPSGSGKSTIISHVlsk--fpFEFSVSHTTRAPRngEVNGKDYFFvtteefesmverqeLLEYIQYn-------- 108 Encephalitozoon cu...
NP_965659   4 IIIIAGPSGVGKTTVSKYLtek--ynIPRVVTHTTRPIRqgEIPGKSYYFetdes----fkklhFFEHVKYg-------- 69  Lactobacillus john...
NP_563368   4 IFCIMGKSGSGKDTILKEInkvedlnLKTIVTYTTRPKRnnETDGVEYFFidkeklddfnregkIIECRVYdtv-----h 78  Clostridium perfri...
BAB71441  416 MLILAGPEACGKRELAHRLcrqfstyFRYGACHTTRPPYfgEGDRVDYHFisq---------dvFDEMVNMgkfiltfsy 486 human

Feature 1         #                                                                           
1GKY       76 -gNYYGSTVASVKqvsksGKTCILDIDMQGvksvka-ipelnaRFLFIAPPsvedlkkrlegrgteteesi--nkrlsaa 151 baker's yeast
AAG12252  210 -gNLYGTSIEAVEvvtddGKRCILDIDVQGarsvra--ssleaIFIFVCPPsfeelekrlrargteteeqi-qkrlrnar 285 trumpet lily
T46191    212 -gNLYGTSIESVEvvtdsGKRCILDIDVQGarsvka--ssldaIFIFVCPPsmkeledrlrargteteeqi-qkrlrnad 287 thale cress
XP_326155  83 -sNFYGTSKATIEeqsakGKVVVLDIEMEGvkqiqa--sgfpaRYVFIAPPseeelekrlrgrgtdkeedi--lkrlaqa 157 Neurospora crassa
NP_704827  78 -nNFYGTLKSEYDkakeqNKICLFEMNINGvkqlkksthiknaLYIFIKPPstdvllsrlltrntenqeqi--qkrmeql 154 Plasmodium falcipa...
EAA75412   83 -gYHYGTSFHSIEdsidrHMVPLFDINMEGvkamkk-fermsaRYVFIAPLnlevletrlrgrgtedenai-qkrlakak 159 Gibberella zeae PH-1
NP_586736 109 -gNYYGTAAAQLRn---pSKTVILDLEYDGvlycrkncpnfviIYIYCDKNiayerlkkrmgsenkkel------egrmr 178 Encephalitozoon cu...
NP_965659  70 -eYQYGSSKEALEkawakNDLVSLIVETDGvksyle-klgkqaYFIYLTVSdfsvlkkrllgrgdkaseidkrlnsfefk 147 Lactobacillus john...
NP_563368  79 gkWYYLTVDDGQInleenNYIVIVTLEAYSefrkyf--gdeklVPLYIDLDdgvrleralkrereqksp-----nynemc 151 Clostridium perfri...
BAB71441  487 gnHKYGLNRDTVEgiardGLASCIHMEIEGvrslky--syfepRYILVVPMnkekyegylrrkglfsraeiefavsrvdl 564 human

Feature 1                                          
1GKY      152 qaelayaetgahDKVIVNDdl--------dKAYKELK 180 baker's yeast
AAG12252  286 aeleqgkspglfDHLLVNDdl--------eSCYQDLK 314 trumpet lily
T46191    288 aeikagkssgifEHKLYNDnl--------eECYKTLK 316 thale cress
XP_326155 158 knelafsktgvhDKIIVNEdl--------eTAYKELE 186 Neurospora crassa
NP_704827 155 nielheanllnfNLSIINDdl--------tLTYQQLK 183 Plasmodium falciparum 3D7
EAA75412  160 keldyaakpgtyDLIIVNDdl--------pTALTELE 188 Gibberella zeae PH-1
NP_586736 179 lyekfdsikdrcDYVIDNShsle----kskREVEEII 211 Encephalitozoon cuniculi
NP_965659 148 rdlhlsdelaekAHVLNNDnw--------eKTAKELD 176 Lactobacillus johnsonii NCC 533
NP_563368 152 rrfladnedfseDKLLNNNiikkynnynleECISEIC 188 Clostridium perfringens
BAB71441  565 yikinqnfpgyfDEVINADdl--------dVAYQKLS 593 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap