1F8H,1C07,1EH2,1FF1,1FI6,1IQ3,2JQ6,2JXC,2KFF,2KHN,2KSP,2MX7,2QPT,3FIA,4CID,2KGR,1QJT


Conserved Protein Domain Family
EH
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cd00052: EH (This model is not part of the current CDD release)
Eps15 homology domain
EH domain is found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.
Links
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Statistics
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PSSM-Id: 527542
Aligned: 275 rows
Threshold Bit Score: 77.4919
Created: 1-Nov-2000
Updated: 13-Jun-2025
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site 1 [ion binding site], 3 residue positions
Conserved feature residue pattern:[DENQ] [DENQ] [DENQ]Click to see conserved feature residue pattern help
Evidence:
  • Structure:1C07: Homo sapiens Eps15 homology domain binds a Ca2+ ion
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #   #      #                                                  
1F8H_A          2 WAVKPEDKAKYDAIFDSLSPv-NGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP 80   human
1C07_A          2 WVVSPAEKAKYDEIFLKTDKdmDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGI 81   human
1QJT_A          3 LTQLSSGNPVYEKYYRQVEAgnTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLSKQEFFVALRLVACAQNGLE 82   house mouse
XP_018101959  205 WIHNDNLVPEFYKNILETTMt-ATGIDTAKLYPILMSSGLPRETLGQIWALANRTMPGKLAKEELYIVLAMIAIAQRGGP 283  African clawe...
XP_021330138    7 LTQLSSGNPVYENFYRQVDPgnTGRVGPTEAALFLKKSGLPDITLGKIWDLADPDGKGFLDKQGFYVALRLVACAQSGHD 86   zebrafish
XP_032826623    7 LTQLSSGNPVYEKYYRLVDPgnNGRVGASEAALFLKKSGLSDLTLGKIWDLADADRKGWLDKQGFYVALRLVACAQNGHE 86   sea lamprey
XP_015151650  395 WIYNDSLVPELYKKILETTLt-PAGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYAVLAMIAVTQRGIP 473  chicken
NP_001026454    7 LTQLSSANPVYEKFYRQVDSanTGRVLASDAAVFLKKSGLTDLVLGKIWDLADTDSKGILNKQEFFVALRLVACAQNGLD 86   chicken
XP_043942018    9 LTQLSSGNPVYEKYYRQVDPanSGKVSASEAAAFLKKSGLTDLTLGKVWDVADSNEKGYLNKQEFFIALRLVACAQNGLD 88   West African ...
XP_064425061  377 WIYNDNLVPDVYKKILGTTMt-PAGIDTAKLYPILMSSGLPRETLGQIWALTNRTTPGKLTKEELYTVLAMIAIMQRGIP 455  coelacanth

Feature 1                  
1F8H_A         81 VPMSLPPAL 89   human
1C07_A         82 DPPHVLTPE 90   human
1QJT_A         83 VSLSSLSLA 91   house mouse
XP_018101959  284 APNLDVLTQ 292  African clawed frog
XP_021330138   87 ISISSLNLP 95   zebrafish
XP_032826623   87 IALSALSHV 95   sea lamprey
XP_015151650  474 AVSPDMLNQ 482  chicken
NP_001026454   87 VSLSSLNLP 95   chicken
XP_043942018   89 VSLSSLTLA 97   West African lungfish
XP_064425061  456 TLSLDALNQ 464  coelacanth

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