1ETH


Conserved Protein Domain Family
COLIPASE

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cd00039: COLIPASE 
Click on image for an interactive view with Cn3D
Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
Statistics
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PSSM-Id: 119409
View PSSM: cd00039
Aligned: 12 rows
Threshold Bit Score: 122.238
Threshold Setting Gi: 149584758
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:lipase interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ##                     #      #                           ###     
1ETH_B         1 VPDPRGIIINLDEGELCLnSAQCKSNCCQHDTilSLSRCALKARE---------NSECSAFTLYGVYYKCPCERGLTCEG 71  pig
P19090        18 VPDPRGIIIHLEDGELCLnSVQCKSKCCHRATglSLARCAPKASE---------NSECSAKTLYGVYYKCPCERGLTCEG 88  dog
P04118        18 APGPRGIIINLENGELCMnSAQCKSNCCQHSSalGLARCTSMASE---------NSECSVKTLYGIYYKCPCERGLTCEG 88  human
1169001       12 VPDPRGVIINLEAGEICLnSAQCKSECCHQESslSLARCAAKASE---------NSECSAWTLYGVYYKCPCERGLTCQV 82  Equus caballus
1169005       18 APDPRGLIINLDNGELCLnSAQCKSQCCQHDSplGLARCADKARE---------NSGCSPQTIYGIYYLCPCERGLTCDG 88  nutria
P42890        18 APGPRGIVINLEEGELCLnSAQCKSGCCHHSSalSLARCAPKASE---------NSECSPQTIYGVYYKCPCERGLTCEG 88  rabbit
AAF67823      18 VPDPRGIIINLDEGELCLnSAQCKSNCCQHDTilSLSRCALKARE---------NSECSAFTLYGVYYKCPCERGLTCEG 88  pig
NP_079745     19 APGPRGLIINLEDGEICLnSMQCKSRCCQHDTilGIARCTHKAME---------NSECSPKTLYGIYYRCPCERGLTCEG 89  house mouse
AAK72258      17 APDPRGILINLEDGEICMnSAQCKSSCCQHFSplGVARCTRKASE---------NSECSPKTLYGIYYKCPCERGLTCES 87  thirteen-lined ...
NP_001107327  23 IPDEKGLIFNLDNGELCLqTAQCKSGCCHRNSgvSLARCAPKAAE---------TQKCSPLHIYGTYYFCPCESGLTCEV 93  western clawed ...
XP_001506434  13 SGDPEGNGSPLWAGTVAL-SVCCTSRDYFSCIs-MYHHCKASMGHppgreagqtEEAEWPCTLYGMYHKCPCEQGLTCET 90  platypus
ABK41022      23 GSLSPTKYNLLELKESCIrNQDCETGCCQRAPdnCESHCAEKGSE---------GSLCQTQVFFGQYRACPCLRNLTCIY 93  human
Feature 1                         # 
1ETH_B        72 DKslVGSITNTNFGICHNV 90  pig
P19090        89 DKsiVGSITNTNFGVCHDA 107 dog
P04118        89 DKtiVGSITNTNFGICHDA 107 human
1169001       83 DKtlVGSIMNTNFGICFDA 101 Equus caballus
1169005       89 DKsiIGAITNTNYGICQDP 107 nutria
P42890        89 DKsiVGSITNTNFGVCLDV 107 rabbit
AAF67823      89 DKslVGSITNTNFGICHDV 107 pig
NP_079745     90 DRsiIGAITNTNYGICLDS 108 house mouse
AAK72258      88 DRtiIGAITNTNYGICLDA 106 thirteen-lined ground squirrel
NP_001107327  94 DRsiVGSITNTDYGYCEDQ 112 western clawed frog
XP_001506434  91 DWtiIGAITNSNYGICLDS 109 platypus
ABK41022      94 SK--NEKWLSIAYGRCQKI 110 human

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