1WYJ,1U2C,1FF5


Conserved Protein Domain Family
CA_like
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cd00031: CA_like 
Click on image for an interactive view with Cn3D
Cadherin repeat-like domain.
Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.
Links
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Statistics
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PSSM-Id: 206635
Aligned: 3 rows
Threshold Bit Score: 106.274
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Ca2+ binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Comment:mediates cell-cell contacts
  • Comment:thought to be essential for trans-association
  • Structure:1FF5_A; Mus musculus E-Cadherin Double Domain binds three Ca2+
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##                                                          # #          
1WYJ_A     12 TITYSVLEETdr--gsLVGNLakdlglslrelitRGAQILSKGnk----qLLQLEQksGNLLLKekLDREELcgstnpCI 85  house mouse
1U2C_A      8 IPDGTAVVGRs-----FRVSIptdli----assgEIIKVSAAGkea-lpsWLHWDPhsHILEGL--PLDTDK------GV 69  house mouse
1FF5_A      5 IPPISCPENEkgefpkNLVQIksnrd----ketkVFYSITGQGadkppvgVFIIERetGWLKVTqpLDREAI------AK 74  house mouse

Feature 1                                  # ## 
1WYJ_A     86 LHFQVLLKSp--------vQFIQGEIQLQDVNDH 111 house mouse
1U2C_A     70 HYISVSAARlgangshvpqTSSVFSIEVYPEDHN 103 house mouse
1FF5_A     75 YILYSHAVSsnge---aveDPMEIVITVTDQNDN 105 house mouse

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