1DQV,2D8K,1WFJ,1UGK,3RPB,1GMI,1DQV,1WFM,3L4C,2R83,2B3R,2Z0U,2ENP,2DMG,3FBK,1DJX,2NSQ,2EP6,2CHD,1DSY,1RH8,3FDW,1BCI,2NQ3,3KWT,2ENJ,2Q3X,3JZY,3BXJ,2JQZ,2RD0,2CJT


Conserved Protein Domain Family
C2

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cd00030: C2 
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C2 domain
The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 175973
View PSSM: cd00030
Aligned: 522 rows
Threshold Bit Score: 31.6535
Threshold Setting Gi: 71021911
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DQV_A        154 LTVTIIKAsnlkam------------dltgfSDPYVKASLiseg-rrlkKRKTSIKKnt--------------------- 199  black rat
NP_001026010   19 LHVELPSQqrrlrhlrniaarniinkngyrlLDTYFTLHLcdntkiykeFYKSEVIKns--------------------- 77   chicken
EFB28718        4 RHLRNIAArnivnr------------nghqlLDTYFTLHLcntekiykeFYRSEVIKns--------------------- 50   giant panda
1353095       532 GLDELSDK-----------------------KFVFAELYVna-----elVMTTKKEKrt--------------------- 562  baker's yeast
EEY57698      463 VIHVGVLSatnlt-------------ksgssVNAICEVTVga------eTFKTSVVKnq--------------------- 502  Phytophthora ...
P46934        962 FEMKLRRAtv--------------------lEDSYRRIMG---------VKRADFLKarlwiefdgekgldyg-gvarew 1011 human
6225859       364 TRSSFMSRtsksksgss-----rnllktddlSNDVCAVLKld------nTVVGQTSWkp--------------------- 411  human
NP_001090246   23 RHLRNIAArnivnk------------ngyrlLDTYFTLHLcdekkiykeFYKSEVVKds--------------------- 69   African clawe...
CAZ28878      340 GKVILAEQkhmdel------------favkiLKKDVILQDdd-----veCAMTERRVla--------------------- 381  Schistosoma m...
XP_002575469  646 HKDVSLRIsiqevk------------nlsakGRNLPIISImtin--lfrQATSVKDKrqrnknqnqfigyvtiplnddsq 711  Schistosoma m...
1DQV_A        200 --------lNPTY----NEALVFDvapes--------------------------------------------------- 216  black rat
NP_001026010   78 --------lNPTW----RSLDFGImpdrldtsvscfvvriwggkkehfqlliewkvnldglkylgqqiharnpneiifgl 145  chicken
EFB28718       51 --------lNPTWr---SLDFGIMpdrl---------------------------------------------------- 67   giant panda
1353095       563 --------aHLKW----NSDYYSVvtdr---------------------------------------------------- 578  baker's yeast
EEY57698      503 --------rSPVW----KQDNSASfea----------------------------------------------------- 517  Phytophthora ...
P46934       1012 ffliskemfNPYY----GLFEYSAtdnyt--------------------------------------------------- 1036 human
6225859       412 -------isNQSW----DQKFTLEldr----------------------------------------------------- 427  human
NP_001090246   70 --------lNPTW----RSLDFGLipdr---------------------------------------------------- 85   African clawe...
CAZ28878      382 --------lPNKSpflvRLHSCFQsm------------------------------------------------------ 399  Schistosoma m...
XP_002575469  712 qceiqkwfiMQPP----QINSNLNfle----------------------------------------------------- 734  Schistosoma m...
1DQV_A        217 -venvGLSIAVVDYDcig-------------------------------------------------------------- 233  black rat
NP_001026010  146 ndgyyGASYEQKDHSgtlknsllqvdqncvr------------------------------------------------- 176  chicken
EFB28718       68 --dtsVSCFVVKIWGgkediyqlliewkvcldglkylgqqiharnqneiifglndgyy-----gapfeykgysnaqrnil 140  giant panda
1353095       579 --rktICRFVLKDQSg---------------------------------------------------------------- 592  baker's yeast
EEY57698      518 --psdDMVVEIRIFDehlf------------------------------------------------------------- 534  Phytophthora ...
P46934       1037 lqinpNSGLCNEDHLsy--------------------------------------------------------------- 1053 human
6225859       428 ---srELEISVYWRDwrs-------------------------------------------------------------- 442  human
NP_001090246   86 -ldtsVSCFVVRIWGgkn-------------------------------------------------------------- 102  African clawe...
CAZ28878      400 ----dRLYLVMEYVNggd-------------------------------------------------------------- 413  Schistosoma m...
XP_002575469  735 --nlqVCHQQHQQQTdtnqtpsinsstgvsgrlrkhsipascfgysnsfsiipnsqyttnsnnklnddnelkynhmelsk 812  Schistosoma m...
1DQV_A        234 ----------------------hneVIGVCRVgpeaadphgreh-------------------------waemlanprkp 266  black rat
NP_001026010  177 ---------nsydvfsllrlhraqcAIKQTQVtvqkigreieekl------------------------rctstsnelkk 223  chicken
EFB28718      141 lqvdqncvrnsydvfsllrlhraqcAIKQTQVtvqki----------------------------------------gke 180  giant panda
1353095       593 ------------------------kVISSSVQplnhli-------------------------------------drtev 611  baker's yeast
EEY57698      535 ---------------------rateLITTLTIplrslpn------------------------------------mqktt 557  Phytophthora ...
P46934       1054 -----------------------fkFIGRVAGmavyhgklldgffirpfykmmlhkpitlhdmesvdseyynslrwilen 1110 human
6225859       443 -----------------------lcAVKFLRLedfld----------------------------------------nqr 459  human
NP_001090246  103 -----------------------dvCRLLIEWkvnldglryi-----------------------------gpqihacnp 130  African clawe...
CAZ28878      414 ----------------------lmhRIQQEGKf----------------------------------------------- 424  Schistosoma m...
XP_002575469  813 kkcswtagvttdsnfnktnkiisksSSSTSTAtspnlspns--------------------------------nsvtnnf 860  Schistosoma m...
1DQV_A        267 vEHWHQL 273  black rat
NP_001026010  224 eSECLQL 230  chicken
EFB28718      181 iEEKLRL 187  giant panda
1353095       612 nKEWIPL 618  baker's yeast
EEY57698      558 kKYPLAL 564  Phytophthora infestans T30-4
P46934       1111 dPTELDL 1117 human
6225859       460 hGMCLYL 466  human
NP_001090246  131 nEIIFGL 137  African clawed frog
CAZ28878      425 -KEPVAV 430  Schistosoma mansoni
XP_002575469  861 iLSENSL 867  Schistosoma mansoni
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