1MSA,1BWU


Conserved Protein Domain Family
B_lectin

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cd00028: B_lectin 
Click on image for an interactive view with Cn3D
Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically recognize diverse carbohydrates and mediate a wide variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein turnover, and innate immune responses.
Statistics
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PSSM-Id: 237995
Aligned: 44 rows
Threshold Bit Score: 73.1151
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
mannose bindingdimerization
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:mannose binding site [chemical binding site]
Evidence:
  • Comment:A consensus sequence motif QXDXNXVXY is essential for mannose binding.
  • Structure:1MSA_A; Mannose interactions with the lectin from snowdrop bulbs.
  • Citation:PMID 8893860
  • Structure:1BWU_Q; Mannose interactions with the lectin from garlic bulbs.
  • Citation:PMID 9887270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    # # # # #                              # # # # # 
1MSA_A      1 DNILYSGETLSTGEFLN------YGSFVFIMQeDCNLVLYDvd-------kpIWATNTGg-lSRSCFLSMQtDGNLVVYn 66  common snowdrop
1840051   155 RSVLKSGEQLSSEQFLN------TQQFKLIAQeDCNLVLYEyn-------ivIWASNTVvgaHAGCRAAMQvDGNFVIYf 221 garlic
1346426     1 DNILYSSEVLHENQYIS------YGPYEFIMQhDCNLVLYEsg-------npTWASNTGg-lALHCRATLQtDGNLVVQn 66  Aloe arborescens
3287960    23 DNVLLSGQTLHADHSLQ------AGAYTLTIQnKCNLVKYQng-------rqIWASNTDr-rGSGCRLTLLsDGNLVIYd 88  lumbah
1840051    13 RNVLTTGETLHAGEHLD------IGQYTLSMRyDCNLVLYEns-------npLWASNTQyeeNVVCQVVLRkDGILVVSy 79  garlic
633044    149 NNLLFSGQVLYGDGRLT------AKNHQLVMQgDCNLVLYGgk--------yGWQSNTHg-nGEHCFLRLNhKGELIIEd 213 taro
2147652    21 QNVLLSGNTLANEESLS------YGSVKFIMQnDCNLVLYGg----------GFQSNTAs-nGKKCTLTLNnNGHLIINd 83  Tulipa sp.
633044     30 TNYLLSGQTLETEGHLK------NGDFDLVMQdDCNLVLYNg----------NWQSNTAn-kGRDCKLTLTdHGELVINn 92  taro
417436      1 MELLRQGEHLHSTSRSTle--skCRKYKLIMQnDGNLVLYIgslksqsdeycLWSSASCgkgHGPYRLSMQeDGNLVIYd 78  Dictyostelium disc...
1518922   139 TASWSIDSTLWSGDVATigptiaNGDYKLELLdTCNLTLSNtkt-----gqvLWYTNTTd-wVHDCYVNIEgNGELKIKy 212 Polygonatum multif...
Feature 1                                # #    # # #              
1MSA_A     67 p---sNKPIWASNTgg--qnGNYVCILQKD---RNVVIYG---TDRWATGTHT 108 common snowdrop
1840051   222 ----nLHAIWSSHTdr--enGNYVLVLQQD---GNVVIYG---PDVWSTGTHV 262 garlic
1346426    67 s---aNRIIWQSNTgtg-tnGDYLLVLQKN---GNVVIVG---PPIWATGTGR 109 Aloe arborescens
3287960    89 h---nNNDVWGSACwg--dnGKYALVLQKD---GRFVIYG---PVLWSLGPNG 130 lumbah
1840051    80 vgseaDYPVWWSSNdrl-dsGNYALVLHED---GNLVIYG---TDIWSTGTAK 125 garlic
633044    214 d---dFKTIWSSSYss--kqGDYVLILRDD---GVAVIYG---PAIWETSPQA 255 taro
2147652    84 g--ltGRVVWRNSNaqn-pvGRYAAVLRPApgtADVAIYG---PAIWSTNDEF 130 Tulipa sp.
633044     93 g---dGSTVWRSGAqs--vkGDYAAVVHPE---GRLVVFS---PSVFKIDPSV 134 taro
417436     79 s---rNSAIWASGTmghgvrGHYSMKLRSS---GQIVVYDkykQILYSSKPCT 125 Dictyostelium discoideum
1518922   213 l---gGATLWSNKVgag-ytNNYVLGLRPD---GKLDTYN---APIWSPTIGP 255 Polygonatum multiflorum

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