1GCC,7WQ5,5WX9,2GCC,3GCC,7ET4,7ET5,7WQ5


Conserved Protein Domain Family
AP2
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cd00018: AP2 (This model is not part of the current CDD release)
AP2 DNA-binding domain of AP2/ERF transcription factors and similar domains
The AP2/ERF transcription factor family is a large group of plant-specific transcription factors involved in regulating plant growth, development, and response to abiotic stress. AP2/ERF transcription factors have four major functional regions: the AP2 DNA-binding domain, the transcription regulation domain, the oligomerization site, and the nuclear localization signal (NLS). The family is divided into five main groups based on the number of AP2/ERF structural domains: AP2 (APETALA2), ERF (ethylene-responsive factor), DREB (dehydration-responsive element binding protein), Soloist, and RAV (related to ABI3/VP1). Each group plays a unique role in plant regulatory mechanisms, influencing various aspects of growth, development, and stress response. This model also includes non-plant AP2 DNA-binding-like domains from bacteria and small eukaryotes.
Links
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Statistics
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PSSM-Id: 512323
Aligned: 287 rows
Threshold Bit Score: 47.8717
Created: 1-Nov-2000
Updated: 18-Feb-2025
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:7WQ5: Arabidopsis thaliana ethylene-responsive transcription factor WRINKLED1 binds dsDNA, contacts at 4A
  • Structure:1GCC: Arabidopsis thaliana ERF1 with bound GCC-box DNA; contacts at 4A
  • Citation:PMID 9736626
  • Comment:The YRG element at the N-terminus and RAYD element at the C-terminus of the AP2 domain play an important role in DNA binding activity
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ###### #  # #   ##             # # # ##          #            
1GCC_A         2 HYRGVRQRp-WGKFAAEIRdp-------akNGARVWLGTFEtaEDAALAYDRAAFRMRGSRA 55  thale cress
7WQ5_A        10 IYRGVTRHrwTGRFEAHLWdksswnsiqnkKGKQVYLGAYDseEAAAHTYDLAALKYWGPDT 71  thale cress
7WQ5_A       112 KYRGVARHhhNGRWEARIGrv--------fGNKYLYLGTYNtqEEAAAAYDMAAIEYRGANA 165 thale cress
131754         7 RYRGFRQRh-WGSWVSEIRhs--------iLKTRIWQGTFEsaEDAARAYDEAARLMCGTRA 59  large-leaved lupine
XP_057831071   6 RYRGVRQRh-WGSWVSEIRhp--------iLKKRVWLGTYEtaEEAARAYNEAAAIMCGNYN 58  Japanese cedar
Q9XI33         6 KFRGVRQRh-WGSWVAEIRhp--------lLKRRIWLGTFEtaEEAARAYDEAAVLMSGRNA 58  thale cress
XP_002985173   6 RYRGVRQRh-WGSWVSEIRhp--------lLKTRVWLGTFEtaEDAARAYDEAARLMGGPRA 58  Selaginella moellendorffii
XP_024371967   6 KYRGVRQRh-WGSWVSEIRhp--------qLKTRVWLGTFEtaEDAAHAYDEAARLMCGAKA 58  Physcomitrium patens
KAH7447031     6 RFRGVRQRh-WGSWVSEIRhp--------lLKTRVWLGTFEtaEDAARAYDEAARLMCGSKA 58  Ceratopteris richardii
XP_025875765 114 SRGGVYQRq-PGRWAVDFRds--------qLKVRQWLGTFPseEEARAAYDAFEVQVRASLS 166 Japanese rice

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