1ELZ,3Q3Q,1EJJ,4FDJ,2XR9,3UN2,1HDH,2D1G,4KAY,2W5Q,1P49,3IDD


Conserved Protein Domain Family
ALP_like

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cd00016: ALP_like 
Click on image for an interactive view with Cn3D
alkaline phosphatases and sulfatases.
This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Statistics
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PSSM-Id: 293732
Aligned: 22 rows
Threshold Bit Score: 76.3053
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EJJ; Geobacillus stearothermophilus Phosphoglycerate Mutase binds to 3-Phosphoglycerate and 2 Mn++, defined by 4A distance.
  • Structure:3Q3Q; Sphingomonas Sp Alkaline Phosphatase binds to methyl phosphate and Zn++ at active site, defined by 4A distance.
  • Structure:4FDJ; human GALNS binds N-Acetyl-D-Galactosamine and Ca++ at active site, defined by 4A distance.
  • Structure:1HDH; Pseudomonas aeruginosa Arylsulfatase binds Ca++ and phosphate at active site, defined by 4A distance.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                                      #                
1ELZ_A     43 KNIILLIGDGMGDseitaarnyaeg---aggffkgidalPLTG-QYTHyalnkktgkpdyvtdGAASATAWSTGVktyng 118 Escherichia coli
1EJJ_A      4 KPVALIILDGFALrdetygnavaqa---nkpnfdrywneYPHT-TLKAcgeavgl-pegqmgnSEVGHLNIGAGRivyqs 78  Geobacillus stearo...
4FDJ_A      5 PNILLLLMDDMGWgdlgvygepsr----etpnldrmaaeGLLFpNFYSan-----------plXSPSRAALLTGRlpirn 69  human
2XR9_A    128 PPLIIFSVDGFRAsymkkgskvm-------pnieklrscGTHApYMRPvyp----------tkTFPNLYTLATGLypesh 190 Norway rat
1HDH_A      5 PNFLVIVADDLGFsdigafggeia-----tpnldalaiaGLRLtDFHTas------------tXSPTRSMLLTGTdhhia 67  Pseudomonas aerugi...
4KAY_A     23 RFVVLVVGETTRAanwglngysrq----ttpllaargdeIVNFpQVRScg-----------tsXAHSLPCMFSTFdrtdy 87  Neisseria meningit...
2W5Q_A     30 KNIIKIHLESFQTflinkkvngkevt-pflnklssgkeqFTYFpNFFHqtg---------qgkTSDSEFTMDNSLyglpq 99  Staphylococcus aureus
1P49_A      6 PNIILVMADDLGIgdpgcygnkti----rtpnidrlasgGVKLtQHLAas-----------plXTPSRAAFMTGRypvrs 70  human
3IDD_A      6 KSIILIVLDGLGDrpgsdlqnrtplqaafrpnlnwlashGING-IXHPispg-------ircgSDTSHXSLLGYDpkvyy 77  Thermoplasma acido...
NP_650920 293 PSVLLWGIDSISRmnleltmp----------rmyeylnnQHWF-ELQGynkm--------gdnTFPNLMAVLTGFnktya 353 fruit fly
Feature 1                                                                                     
1ELZ_A    119 algv---------------------------------------------------------------------------- 122 Escherichia coli
1EJJ_A     79 ltriniairegefdrnetflaamnhvkqhgtslhlfgllsdggvhshihhlyallrlaakegvkrvyihgfldgrdvgpq 158 Geobacillus stearo...
4FDJ_A     70 gfyttnaharn--------------------------------------------------------------------- 80  human
2XR9_A    191 givgnsmydpvfda------------------------------------------------------------------ 204 Norway rat
1HDH_A     68 gigtmaealtpe-------------------------------------------------------------------- 79  Pseudomonas aerugi...
4KAY_A     88 de------------------------------------------------------------------------------ 89  Neisseria meningit...
2W5Q_A    100 gsaf---------------------------------------------------------------------------- 103 Staphylococcus aureus
1P49_A     71 gmaswsrtgv---------------------------------------------------------------------- 80  human
3IDD_A     78 pgrgpfealglgxdirpgdlafranfatnrdgvivdrragrenkgneeladaisldxgeysfrvksgvehraalvv---- 153 Thermoplasma acido...
NP_650920 354 narchp-------------------------------------------------------------------------- 359 fruit fly
Feature 1                                                                                     
1ELZ_A        --------------------------------------------------------------------------------     Escherichia coli
1EJJ_A    159 tapqyikelqekikeygvgeiatlsgryysmdrdkrwdrvekayramvygegptyrdpleciedsykhgiydefvlpsvi 238 Geobacillus stearo...
4FDJ_A        --------------------------------------------------------------------------------     human
2XR9_A        --------------------------------------------------------------------------------     Norway rat
1HDH_A        --------------------------------------------------------------------------------     Pseudomonas aerugi...
4KAY_A        --------------------------------------------------------------------------------     Neisseria meningit...
2W5Q_A        --------------------------------------------------------------------------------     Staphylococcus aureus
1P49_A        --------------------------------------------------------------------------------     human
3IDD_A    154 ----------------------------------------------------------------------------sgpd 157 Thermoplasma acido...
NP_650920     --------------------------------------------------------------------------------     fruit fly
Feature 1                                                                                     
1ELZ_A    123 ---------------------------------------------------------------------dihekdhpTIL 133 Escherichia coli
1EJJ_A    239 vredgrpvatiqdndaiifynfrpdraiqisntftnedfrefdrgpkhpkhlffvclthfsetvagyvafkptnldnTIG 318 Geobacillus stearo...
4FDJ_A     81 -------------------------------------------------------------aytpqeivggipdseqLLP 99  human
2XR9_A    205 -----------------------------------------------------------sfhlrgrekfnhrwwggqPLW 225 Norway rat
1HDH_A     80 -------------------------------------------------------------legkpgyeghlnervvALP 98  Pseudomonas aerugi...
4KAY_A     90 ----------------------------------------------------------------------ikaehqdNLL 99  Neisseria meningit...
2W5Q_A    104 --------------------------------------------------------------------slkgdntyqSLP 115 Staphylococcus aureus
1P49_A     81 --------------------------------------------------------------flftassgglptdeiTFA 98  human
3IDD_A    158 lsdxigdsdphreglppekirptdpsgdrtaevxnayleearrilsdhrvnkervkngrlpgnellvrsagkvpaipSFT 237 Thermoplasma acido...
NP_650920 360 -------------------------------------------------------------------ekvrgldacpFIW 372 fruit fly
Feature 1                                                                                     
1ELZ_A    134 EMAKAag-lATGNVStaelqdatpaalvahvtsrkcygpsatsekcpgnalekggkgsiteqllnaradvtlgggaktfa 212 Escherichia coli
1EJJ_A    319 EVLSQhg-lRQLRIAetekyphvtffmsggreeefpgedr---------------------------------------- 357 Geobacillus stearo...
4FDJ_A    100 ELLKKag-yVSKIVGkwhlghrpqfhplkhgfdewfgspnchfgpydnkarp---------------------------- 150 human
2XR9_A    226 ITATKqg-vRAGTFFwsvsi------------------------------------------------------------ 244 Norway rat
1HDH_A     99 ELLREag-yQTLMAGkwhlglkpeqtphargfersfsllpgaanhygfeppyd--------------------------- 150 Pseudomonas aerugi...
4KAY_A    100 DIVQRag-vEVTWLEndsgckgvcgkvpntdvt----------------------------------------------- 131 Neisseria meningit...
2W5Q_A    116 AILDQkqgyKSDVMHgdyktfwnrdqvykhfgidkfy------------------------------------------- 152 Staphylococcus aureus
1P49_A     99 KLLKDqg-ySTALIGkwhlgmschsktdfchhplhhgfnyfygisltnlrdckpgegsvfttgfkrlvflplqivgvtll 177 human
3IDD_A    238 EKNRXk---GACVVGspwlkglcrllrxdvf------------------------------------------------- 265 Thermoplasma acido...
NP_650920 373 KDFKDk--gYTTAFAedwskfstfdyssrgffnpptdvygrpl------------------------------------- 413 fruit fly
Feature 1                                                                                     
1ELZ_A    213 etatagewqgktlreqaqargyqlvsdaaslnsvteanqqkpllglfadgnmpvrwlgpkatyhgnidkpavtctpnpqr 292 Escherichia coli
1EJJ_A    358 -----------------------------------------------------------------ilinspkvptydlkp 372 Geobacillus stearo...
4FDJ_A    151 ------------------------------------------------------nipvyrdwemvgryyeefpinlktge 176 human
2XR9_A        --------------------------------------------------------------------------------     Norway rat
1HDH_A    151 -----------------------------------------------------estprilkgtpalyvederyldtlpeg 177 Pseudomonas aerugi...
4KAY_A    132 -------------------------------------------------------------------------slnlpey 138 Neisseria meningit...
2W5Q_A    153 --------------------------------------------------------------------datyydmsdknv 164 Staphylococcus aureus
1P49_A    178 tl---------------------aalnclgllhvplgvffsllflaaliltlflgflhyfrplncfmmrnyeiiqqpmsy 236 human
3IDD_A    266 --------------------------------------------------------------------------dvpgat 271 Thermoplasma acido...
NP_650920 414 --------------------------------------------------------------vlavekeltilqrgqmpy 431 fruit fly
Feature 1                                         #                                           
1ELZ_A    293 ndsvptlaqmTDKAIEllsk--nekgFFLQVEGasIDKqdha-------------------------------------- 332 Escherichia coli
1EJJ_A    373 emsayevtdaLLKEIEad------kyDAIILNYanPDMvghs-------------------------------------- 408 Geobacillus stearo...
4FDJ_A    177 anltqiylqeALDFIKrqar---hhpFFLYWAVdaTHApvyaskpf---------------------------------- 219 human
2XR9_A    245 -----pherrILTILQwlslpdnerpSVYAFYSeqPDFsghky------------------------------------- 282 Norway rat
1HDH_A    178 fyssdafgdkLLQYLKerdq---srpFFAYLPFsaPHWplqapreivekyrgrydagpealrqerlarlkelglveadve 254 Pseudomonas aerugi...
4KAY_A    139 crngecldniLLTKFDevlnk-ndkdAVLILHTigSHGptyyeryteaerkftpt------------------------- 192 Neisseria meningit...
2W5Q_A    165 vnlglkdkifFKDSANyqak--mkspFYSHLITltNHYpftldekdati------------------------------- 211 Staphylococcus aureus
1P49_A    237 dnltqrltveAAQFIQrnt----etpFLLVLSYlhVHTalfsskdf---------------------------------- 278 human
3IDD_A    272 gtvgsnyrgkIEKAVDlts-----shDFVLVNIkaTDVaghd-------------------------------------- 308 Thermoplasma acido...
NP_650920 432 clgrkpaseyIYDMGVqftmvnrnstFFGMFWTntFSH------------------------------------------ 469 fruit fly
Feature 1                                                                   ##                
1ELZ_A    333 -----------------------anpcGQIGETVDLDEAVQRALEfak---kegNTLVIVTADHAHasqivapdtkapgl 386 Escherichia coli
1EJJ_A    409 -----------------------gklePTIKAVEAVDECLGKVVDail----akGGIAIITADHGNadevltpdg----- 456 Geobacillus stearo...
4FDJ_A    220 --------------------lgtsqrgRYGDAVREIDDSIGKILEllqdlhvadNTFVFFTSDNGAalisapeqggsngp 279 human
2XR9_A    283 ----------------------gpfgpEMTNPLREIDKTVGQLMDglkqlrlhrCVNVIFVGDHGMedvtcdrteflsny 340 Norway rat
1HDH_A    255 ahpvlaltrewealedeeraksarameVYAAMVERMDWNIGRVVDylrrqgeldNTFVLFMSDNGAegalleafpkfgpd 334 Pseudomonas aerugi...
4KAY_A    193 -----------cdtneinkctratlvnTYDNTVLYVDQFIDKVIRklen-rddlESVVHYVSDHGEslgengmylha--- 257 Neisseria meningit...
2W5Q_A    212 ----------------eksntgdatvdGYIQTARYLDEALEEYINdlkkkglydNSVIMIYGDHYGisenhnnamekll- 274 Staphylococcus aureus
1P49_A    279 --------------------agksqhgVYGDAVEEMDWSVGQILNlldelrlanDTLIYFTSDQGAhveevsskgeihgg 338 human
3IDD_A    309 -----------------------gnypLKRDVIEDIDRAXEPLKSig------dHAVICVTGDHSTpcsfk--------- 350 Thermoplasma acido...
NP_650920 470 ---------------------------NDFSMPSAMDERMVKYMRtldkngimdNTIIIFFSDHGSrfgplrnl------ 516 fruit fly
Feature 1                                                                                     
1ELZ_A    387 tqalntkd------------------------------------------------------------------------ 394 Escherichia coli
1EJJ_A        --------------------------------------------------------------------------------     Geobacillus stearo...
4FDJ_A        --------------------------------------------------------------------------------     human
2XR9_A    341 ltnvdditlvpgtlgriraksinnskydpktiiaaltckkpdqhfkpymkqhlpkrlhyannrriedihllvdrrwhvar 420 Norway rat
1HDH_A    335 llgfldrhydnslenigr-----------------------------------------------------------ans 355 Pseudomonas aerugi...
4KAY_A        --------------------------------------------------------------------------------     Neisseria meningit...
2W5Q_A        --------------------------------------------------------------------------------     Staphylococcus aureus
1P49_A    339 sn------------------------------------------------------------------------------ 340 human
3IDD_A        --------------------------------------------------------------------------------     Thermoplasma acido...
NP_650920     --------------------------------------------------------------------------------     fruit fly
Feature 1                                                                              
1ELZ_A    395 -------gavmvmsygnseedsqehtgsQLRIAAYgphaa--------------nvvgLTDqTDLFYTMKAAL 446 Escherichia coli
1EJJ_A    457 -------------------kpqtahttnPVPVIVTkkgi---------------klrdGGIlGDLAPTMLDLL 495 Geobacillus stearothermop...
4FDJ_A    280 ---------------flcgkqttfeggmREPALAWwpghvta----------gqvshqLGSiMDLFTTSLALA 327 human
2XR9_A    421 kpldvykkpsgkcffqgdhgfdnkvnsmQTVFVGYgptfky------------rtkvpPFEnIELYNVMCDLL 481 Norway rat
1HDH_A    356 yvwygprwaqaatapsrlykafttqggiRVPALVRyprlsrq----------gaishaFATvMDVTPTLLDLA 418 Pseudomonas aeruginosa
4KAY_A    258 -----------------apyaiapsgqtHIPMVMWfskafrqhggidfqclkqkaaenEYShDHYFSTVLGLM 313 Neisseria meningitidis MC58
2W5Q_A    275 ---------------gekitpakftdlnRTGFWIKipgksg------------ginneYAGqVDVMPTILHLA 320 Staphylococcus aureus
1P49_A    341 -------------giykggkannweggiRVPGILRwprviqa----------gqkidePTSnMDIFPTVAKLA 390 human
3IDD_A    351 -----------------------dhsgdPVPIVFYtdgvxndgvhl-fdelssasgslRITsYNVXDILXQLA 399 Thermoplasma acidophilum
NP_650920 517 ---------------------dsgfveeRLPFIYIrvprwirekypkllrnlqmnknrLTSpYDIHATLRHIL 568 fruit fly

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