Conserved Protein Domain Family
GMC_mycofac_2
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TIGR04542: GMC_mycofac_2 
GMC family mycofactocin-associated oxidreductase
This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to the bacterial genus Gordonia, and seem to replace the related family TIGR03970, which occurs in Actinobacteria generally but not in the genus Gordonia. Members of both this family and TIGR03970 are associated with the mycofactocin biosynthesis operon in Actinobacteria. [Unknown function, Enzymes of unknown specificity]
Links
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Statistics
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PSSM-Id: 275335
Aligned: 11 rows
Threshold Bit Score: 483.431
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_007619261   7 DVIVVGAGSAGCVVAERLSREEDREVLVLEAGPDRWPTGYERDLRSL---PIDRDSPI----ATHIVEDSGLAMVRGRAL 79  Gordonia soli
WP_005170155  12 DAVIVGAGSAGCVLAERLSRDDERSVLLLEQGSGNRPDAHTLDLGTL---PISDGEPY----VTHYRGSSALSIVRGRGL 84  Gordonia aichie...
WP_005193574   4 DVVIVGAGSAGCVLAERLSRDPGRSVLLLEAGP-GLPGAEVIDLFHL---PVGADAERmgrtVSYPVSPAELSVVRGHGI 79  Gordonia amarae
WP_014361015  15 DVVIVGAGSAGSVLADTLSRDGTRSVLLLEQG-SGWPDAAVRDLRTL---PISASSGF----VTVHDAPPGQTVVRGRGL 86  Gordonia polyis...
WP_004020567  11 DVVIVGAGSAGCVLAERLSREPERTVVLLERGPAGLPTPADLDLRRL---PIDDAAPH----AVRHATDLGVYAARGSAL 83  Gordonia terrae
WP_012835455  13 DVVIVGAGSAGCVLAEQLSRNPDRSVLVLERGPAGWPAAQDRDVRRL---PVEAGARH----AVAHGSTNGGGVVRGSGL 85  Gordonia bronch...
WP_007320489   4 DVLVVGAGSAGCVVAERLSRNADRRVVVLEAGP-EVTGGDVHRLDRMllgSVAAPSRY----ARWYRADP--PVVRGRAV 76  Gordonia araii
WP_020109632   6 DVIVVGAGSSGCVVAERLSRDPARRVLWLEAG-GDKAAATELRLDRL---PVAAGSQR----VVHYPSRQGFDLPRGRGL 77  Nocardia sp. 34...
WP_006895661  13 DVVVVGAGSAGCVVADRLSRDAGRKTLLLEAGHALPPRTAVTAMSRL---PIAPGSER----VRRVRERRGRDVVRGYGA 85  Gordonia sihwensis
WP_008376035   5 DVLVVGAGSAGCLVAEFLSRDSSRRVMVVEAG---RGAVFESRLDRL---PIDHP-VR----AAPIPERRGRPMVRGRGL 73  Gordonia malaquae
WP_026303231   1 --MVIGAGTAGCIVAQELS-NAGRTVALFDEG----AGSAVGPLSRL---PLTDG-PQ----VRWYSTGDGGLLPRGRGP 65  Gordonia kroppe...

WP_007619261  80 GGSSVVNGGYFLRAHADDLAGWSSGWTAERVAGAYDELDrp------gGTMSASPFADDELSEATLAFENHWAKSYPVRP 153 Gordonia soli
WP_005170155  85 GGSSTVNGAYFMRWHRDDFDSWRGQWTLGAIDKAYAEIE---------QRMEAAPYRDLDLADTAIAFEKYWGTVYSSRN 155 Gordonia aichie...
WP_005193574  80 GGSAAVNGAYFLRWHREDFGDWE--HSIGDIEAAYTEVE---------AAMSVSPFGDDELPDAAHAFEAWWGTHLPTRR 148 Gordonia amarae
WP_014361015  87 GGSSAINGGYFLRWHRDDFAGWPSGWGVDDVEAAYRELDda------dGPMSVHPFGEDDLGPAARAFERFWSTRVPVRD 160 Gordonia polyis...
WP_004020567  84 GGSSAVNGGYFLRWHRDDFGSWPAGWEPDAIADAYDELDap------aGTMGVEPVADDELGDAGRAFERYWSERAPVRP 157 Gordonia terrae
WP_012835455  86 GGSSVINGGYFLRWHRDDFTRWPSGWEIDRIDAAYDELDrp------gGPMGVEPVGDNELGDAASAFEEYWAACMPVRD 159 Gordonia bronch...
WP_007320489  77 GGSSVVNGGYFLRAHRDDFAEWGGPFTMDAITAAYDELDggvpggapaGRMSVGPVRDDEVGPLVRRLEERWAAAPP--- 153 Gordonia araii
WP_020109632  78 GGSSAVNGGYFMRWHKADFAGWP--WPQQEIAAAYDRLDgge---aggGSMHVAAFADDELHEYARAFENHWHEQ-GFGD 151 Nocardia sp. 34...
WP_006895661  86 GGSSAVNGGYFLRGHRDDYAAWP--WPASRIDDAFDVLDgga---aggGVMRVREVLDGELGPAGSAFETYWRTRVAAGP 160 Gordonia sihwensis
WP_008376035  74 GGSSAINGGYFLRGHRADYFSWP--WPIDEVEAAFTEVE---------RIMRVHRFSDAELGDVARATETWAGPQTG--- 139 Gordonia malaquae
WP_026303231  66 GGSALINAGYFLRWHQADFGGWP--WPIETVARAYDLVDggg----aaGWLRASRVADDELSPIAAAFE-HAATAAGLPA 138 Gordonia kroppe...

WP_007619261 154 IESREVTVGVNRVVSNR----EGGLRRTAAEAYLRPALGRPGLTVRASAAVESLVMR-DRRVVGVR---VAGAEIEAGEV 225 Gordonia soli
WP_005170155 156 IDDPWPTVGVNRVRSNS----VDGRRRTAADAYLRSHLDRRNLRVRSGARVEKVVLA-GGRAHGVV---CNGEKIRAGEV 227 Gordonia aichie...
WP_005193574 149 LDDRWPVTGVNRVHSNSirdaAGGRRVTTAEAFLRPALGRPNLTVRTAARVSALDMA-GTRVTGVH---CGAEVIGAGEV 224 Gordonia amarae
WP_014361015 161 VTDRWPIIGLNRVLGNN----AHRLRTTSAEAFLRPALARPNLVVRTGIRVHEILMA-GRRATGLRetgSGGTDIACDEV 235 Gordonia polyis...
WP_004020567 158 IAQRWPVVGLNRVLTNR----SGVARRSAADAYLVPALSRPNLRVLTGRVVDRLDTVrGPTVTGVR---AGSLSVRAGEV 230 Gordonia terrae
WP_012835455 160 VGQRWPTIGVNRVLSNR----SGDLRMTAAEAFVRPASARPNLRVLTGCDVDELVVTgGRLITGVR---TGTAVTGAGEV 232 Gordonia bronch...
WP_007320489 154 --GPWPGVGIQRVPVNR----CDGQRWSAADAYLAPAGDRPNLTVRADCSVSRLVVE-SGRVVGVVl--SGGEQVRAGEV 224 Gordonia araii
WP_020109632 152 STAPWPDVGVVRVRSNR----DGWLRRSAAESIAQRIEGRKNLQLMTDSEVIGLRRS-GDRVTAVV---VGEQVIAADEV 223 Nocardia sp. 34...
WP_006895661 161 -EGAWPVVGVNRVRSNSirdgGVLRRWTAMEAF--------APAVRGGSEVISLASA-GGRVTGVH---TAAGRIDAATV 227 Gordonia sihwensis
WP_008376035 140 --GEWPRVGVNRVRTNS----VDGVRWTTANVL---SVDRPNLLVRAETPVARLLVR-AGRAIGIEt--GDGEAISAGEV 207 Gordonia malaquae
WP_026303231 139 VAGPWSDVGVNRLRLNR----RGGDRWTAWDAI-EP---LRDVAVHGGARVDRIERVgPGWAVA-----TDSAIYSAPTV 205 Gordonia kroppe...

WP_007619261 226 IVCAGTLGTAALLERSRVpALADlfa-------sgVGLREHREVLVHYRPRVSASPRP--LLQSVVHTDDGSEIRFYSDD 296 Gordonia soli
WP_005170155 228 ILCAGTLGTTELLLRSQI-AGGR------------IEVHEHREVLVGYRRREQITRGP--LLPTVVHTDDGLEIRCYRDD 292 Gordonia aichie...
WP_005193574 225 VLCAGTLGTAALLFASGL-VTGP------------LRVVEHREMLVHYRLSGPTRPAP--LLPSVVHTGYGVEIRCYGGD 289 Gordonia amarae
WP_014361015 236 ILCAGTLGTAGILLRSIPeVIGPsg---------vLVAGEHREVLVGYRRRSPDDLRP--LLPTVVHTDDGIEIRCYSDD 304 Gordonia polyis...
WP_004020567 231 ILAAGTLGTAGILLRSEV-PGLPgsgargrsdvrsLTAGEHRGLAVSYSRRSPADAGM--VLPTVLHTENGLEIRCYRDD 307 Gordonia terrae
WP_012835455 233 ILSAGTLGTAGILLRTGL-ETLDas--------agLVVSEHRSLAVSYRRRGPVTPGP--LLPSVVHTPGALEIRCYRDD 301 Gordonia bronch...
WP_007320489 225 VVCAGGLGSAALLMRSGV-VDGS------------LPAFEHREILVRYAPAVRPEPAPv-LLPSVAHTADGSEIRWYADD 290 Gordonia araii
WP_020109632 224 ILCAGTLGTAQLLARSGI-VGAQs-----------IGVWEHREVLVRFTPATPPAPAAraLLQSVLHTDDGIEIRCYNGD 291 Nocardia sp. 34...
WP_006895661 228 VLTAGTLGTAELVLP--L-LGGE------------LSVYEHPESLVRFAARRPLRTQV--LLPTVVHTADGLEIRCYSDD 290 Gordonia sihwensis
WP_008376035 208 VVCAGTTGTASLMAP----IVGP------------MPLHEHAERIVRFTPRRALVSTA--LLQTVIHTSSGLEIRPYSDD 269 Gordonia malaquae
WP_026303231 206 VLAAGTLGTARILLRSNL-VDGPe-----------LEFIEHREQLVRYHVRGAAPPATa-LLHTVIHLADGVELRPYNGG 272 Gordonia kroppe...

WP_007619261 297 LAKYIRSVPPRGPAVGVAAMVPAASGTVRFD-RGAPLVHLGAPSVDVLDQLDRGVDRVRSMLADPAVADVVDP--ATVEV 373 Gordonia soli
WP_005170155 293 FARYIRGLGQSGPAVGIAAMRPAAPGSVYLDsSGGLVVRLEPPDDEVRDRLSRTADEVVEMLGSPMFSDMVES--GSVGI 370 Gordonia aichie...
WP_005193574 290 FADYIDGVPPTGPAVGVAAMVPGTPGELTWD-GRRLAVDLGTAT-QLPDRLRPELEQVRDMLASETFRGIVEP--GSVRL 365 Gordonia amarae
WP_014361015 305 FERYVTGSAGGSQAVGVCGMLQAGPARLTSAsGGSVRVRFDDLNESVAAPLWATASDVVDMLASAEFDDVVVP--DSISV 382 Gordonia polyis...
WP_004020567 308 FASYIHGLPVSGPIVEVTAMRH-SPVRIVAD-HSRVRMEFVEPDPDTAASLRTAAAGVVEMLRSPEFTDVVVP--GSVRI 383 Gordonia terrae
WP_012835455 302 FASYIRGLAPTGPEIGIAAMRDGA-ARLTLR-GRDVEVDFEPVDAATAEALRTTAGEVSEMLRSPGFASFVEP--GSVSV 377 Gordonia bronch...
WP_007320489 291 FARFIPGLASSTAVVGVAQMHPPRPGELRWD-GERLDVE---PAGMRVDEVSAAVAEVVEALSSAELADVVVD--GSVAV 364 Gordonia araii
WP_020109632 292 FADFISGVPATGPAMGVALMHTREPGSIAWDlTSGLVVDLGEVSRSDREKLAAWAERVREMLDGPRFAALVDRsgGGAVI 371 Nocardia sp. 34...
WP_006895661 291 FASFIDGIPAGGVPIGVADMTHGTTGRIGIE-GDEVVIDLGVPDAGGLERLSEGVDEVLEMLHSPAFDGLVEP--GSVTV 367 Gordonia sihwensis
WP_008376035 270 FASF-TSLAQTGVPIGVADM-AGTQGAVA---DG--VVDLGEPDADSAGRLEVGVETVVRMLGSEEFVDLVEP--GSVRV 340 Gordonia malaquae
WP_026303231 273 FASYIPGVEPDAAAVGVALMRPQSRGRLTLDpDGELRVALPIPTADDRRRIDAGVRTVRELLAGTELKGVAEP--GSASA 350 Gordonia kroppe...

WP_007619261 374 DPVVRTSQHAWGTLP------MGTRTDPTGAVDGVPGLRVVDGSILPVDLHSGPHATIMMMACLIGDRL 436 Gordonia soli
WP_005170155 371 DPVLRTSQHAWGSMP------MGERTDWLGGVLGIQNLRIVDGSILPTAGRSGPHATTMMVAAVIAHAL 433 Gordonia aichiensis
WP_005193574 366 DPVVRTSQHACGSLP------MGDRTDASGNLDGVRGLRIIDGSVLPPGGRSGPHATTVMVAALLS--- 425 Gordonia amarae
WP_014361015 383 DPVIRSSQHAFGSLP------MGVRTDWLGGVVGVRGLRVVDGSILPSPGRSGPHATIMMTARRIGAAL 445 Gordonia polyisoprenivorans
WP_004020567 384 ADRAGFSQHAWGTVP------MGIRTDWLGGVSGTRGLRIVDGSILPGSGRSGPHATIMMMASRIGTVL 446 Gordonia terrae
WP_012835455 378 ADGFGISQHAWGSMG------MGVRTDWLGGVYGTKGLRIVDGSILPTGGRSGPHATIMMVASRIGARL 440 Gordonia bronchialis
WP_007320489 365 DPAVGTSQHGWGAMA------MGERTDWFGAVDGVAGLRIVDGSILP-NVSSGPHATVMMVAIVIADAL 426 Gordonia araii
WP_020109632 372 DSVVRTSQHAWGTLP------MGVDTDWLGRVTAVSGLRVLDASILPTAGSSGPHATVMMVASYIADQI 434 Nocardia sp. 348MFTsu5.1
WP_006895661 368 DPVVGLSSHAWGTLP------LGATVAPDGSVHGVPGLHVADGSVLPAPLRSGPHASVMATAALIAEEL 430 Gordonia sihwensis
WP_008376035 341 DPTVGMSQHAWGTLPagtagtAGTAVDADGRVDGVRGLRVIDGSILPGPLSSGPHATILMLAALIASRW 409 Gordonia malaquae
WP_026303231 351 DEPLGTSQHACGTTP------LGTATTDDGELRDHAGVFVADGSVLPTGGSAGPHATIAAVAAVIGNRL 413 Gordonia kroppenstedtii
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