Conserved Protein Domain Family
nonproteo_OH
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TIGR04531: nonproteo_OH 
putative nonproteinogenic amino acid hydroxylase
This extremely rare protein family, a branch of the 2-oxoglutarate dependent oxygenase family related to proline 3-hydroxylase, appears only in natural product biosynthetic clusters that include nonribosomal peptide synthases. One members is PlyP from the polyoxypeptin A cluster, suggested to hydroxylate 3-methylproline. Another, GetF from the GE81112 biosynthetic gene cluster, is a proposed to hydroxylate pipecolic acid.
Links
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Statistics
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PSSM-Id: 275324
Aligned: 3 rows
Threshold Bit Score: 526.456
Created: 10-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CBL93717      94 TLPIDSYDFDEELSIIDSNDAGGEYDAFTFGSWSAHVLANSGGSDEDTSFRPYEGRLALTELGRKLPKIMSIVHDNFPLE 173 Streptomyces sp...
AGZ15468       1 MLPIDSYDLDSELSVVDRHEYGGEYDAFTFGSWSGHVLANGSGADSDTAFRPHDGRLTLTELGRQLPGIMSLVTDNFPLD 80  Streptomyces sp...
WP_011603712   9 TLPIDSYDLDSELSIVDQHNYQGEYDAFTFGTWSAHALANGSGAEYDLSFRPHSDRLTRTELGSRLPGIMALVTDHFPLD 88  Frankia alni

CBL93717     174 RLQWVRIFSLSDGILAPHVDFLEFSEPGTRLQIPLRTDEDSLHSENDIVYHLRRGEVWKIHTTVPHSAQSVSPFARLSLC 253 Streptomyces sp...
AGZ15468      81 RLQWVRIFSLRDGIILPHVDFLEFAEPGTRLQIPLRTSEESLHSENEFVYHIRRGEVWKIHTTDPHAARSSSGTARLSLC 160 Streptomyces sp...
WP_011603712  89 RLQWVRIFSLRDGIIAPHVDFLEFARPGTRLQIPLRTTAESLHSENDVVYHLRRGEVWQIHTTDPHSALSAAGAPRLSLC 168 Frankia alni

CBL93717     254 LDFAGADEPVEIKNSIPPELPVRIISRPSVTEAEVEELLSSAAGLSADTLRTSFRRFAAVHFARRADATAAFDWFIEAAV 333 Streptomyces sp...
AGZ15468     161 LDFSDAEEPIAIRNDIPATEPIRIMDRPDPTEAELEELIGSGGNMTPETMRADFRRFAELHFERRAHITAAFDWYLAAVR 240 Streptomyces sp...
WP_011603712 169 LDFAGSDEPVKIRGDVPATEPIHIVDRPAPTETELEELLTCGNALATGSMRHDFRRFAALHFARRAHAAAAFDWFEQAAA 248 Frankia alni

CBL93717     334 RTGDGALAEKAKAFRTYCIEKRGYREAFEW 363 Streptomyces sp. L-49973
AGZ15468     241 RTENPDMVATAQAFRTYCIEKRVDGEAFDW 270 Streptomyces sp. MK498-98F14
WP_011603712 249 RTGDPAAVAKARAFRTYCIEKRSYGEAFAW 278 Frankia alni
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