Conserved Protein Domain Family
prot_M_MG281

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TIGR04525: prot_M_MG281 
IgG-blocking protein M
Members of this family, including MG_281 of Mycoplasma genitalium, bind conserved regions of the IgG light chain sequences, blocking IgG's normal function of antigen-specific binding. It is therefore an important virulence protein. Members of this family are found also in Mycoplasma pneumoniae, M. penetrans, M. gallisepticum, and M. iowae. Model TIGR04524 describes a region within this protein that is shared by many additional Mycoplasma and Ureaplasma proteins. [Cellular processes, Pathogenesis]
Statistics
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PSSM-Id: 275318
Aligned: 5 rows
Threshold Bit Score: 539.505
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_004025288   1 MKKKFKILLT-------------------------SASVIAMGAGVGVYVATTN------TQNTSVNVNNNENINYKTNG 49  Mycoplasma iowae
WP_010874756  16 LKKGGFWALGlfgaainafsavlivnevlrlqsgeTLIASGRSGNLSFQLYSKVnqnaksKLNSISLTDGGYRSEIDLGD 95  Mycoplasma pneu...
WP_014894651  12 FKRKLFWTIGvlgagalttfsa-vmitnlvnqsgyALVVPGRSGNLGFKLFSTQspsaevKLKSLSLNDGSYQSEIDLSG 90  Mycoplasma geni...
WP_014885954   9 ykkALLWIFGsvglisvllsg----iiytsvkisnSLYQDKLISGQNQPLAPVNrligfqTLAKFRIEDLDFELQKKIYS 84  Mycoplasma gall...
WP_011076965   7 FRKGLLAIIG-------------------------GLTVAGAGIGVTLPLVTSNnnhensLNNSSSNNG----SNLKVNG 57  Mycoplasma pene...
WP_004025288  50 TVVTGDKLTFsAVVQQNSNISTQAFISDGTKPVGTYNKEINLGKDSITPKYTSGYVETYLESGDTVSRYSSSEYHNNRTL 129 Mycoplasma iowae
WP_010874756  96 GSNFREDFRN-FANNLSEAITDAPKDLLRPVPKVEVSGLIKTSSTFITPNFKAGYYDQVAADGKTLKYYQSTEYFNNRVV 174 Mycoplasma pneu...
WP_014894651  91 GANFREKFRN-FANELSEAITNSPKGLDRPVPKTEISGLIKTGDNFITPSFKAGYYDHVASDGSLLSYYQSTEYFNNRVL 169 Mycoplasma geni...
WP_014885954  85 STVESAELVN-RSAVLVDDS--VLENHDGELTSVQSDPQVPAPVKILAKEQTGHTSDFVSGYSDDNKYYQSPYYYNDRVY 161 Mycoplasma gall...
WP_011076965  58 SVISTDNLNI-VATGLSSNVSSQVSR-------QSLSSSSSSESTVDSKYTAKKKLTTVS--GQEKEYLVSTVYENNRKF 127 Mycoplasma pene...
WP_004025288 130 MPILDTKEHYYTSER----TYSEIQKG----IYRGWEISTPSINYGEKFS--------YNASAVLKTVFKQLKQETVSAV 193 Mycoplasma iowae
WP_010874756 175 MPILQTTNGTLTANNr---AYDDIFVDqgvpKFPGWFHDVDKAYYAGSNGqseylfkeWNYYVANGSPLYNVYPNHHFKQ 251 Mycoplasma pneu...
WP_014894651 170 MPILQTTNGTLMANNr---GYDDVFRQv--pSFSGWSNTKATTVSTSNNLty----dkWTYFAAKGSPLYDSYPNHFFED 240 Mycoplasma geni...
WP_014885954 162 MPILDSPT-IYLKNEr---TSSDIGLN----NYQGWIAVGHARVNSRVS----------VFNYRATDELLAKFNNLPDRL 223 Mycoplasma gall...
WP_011076965 128 MPILAYDEDISYNNYqqsrEYKDVVYG----NFPGWDKKVAVVHQIDNVDlsk---ayASVAEFTPTEILKNPSAPESVK 200 Mycoplasma pene...
WP_004025288 194 QFNLGLSDTSIES----INSFLKTNSDIQFVTIKGISQDTD--LSKLVLPESVQKLTLLGQRNTINDLKLP-SELQEIEI 266 Mycoplasma iowae
WP_010874756 252 IKTIAFDAPRIKQgntdGINLNLKQRNPDYVIINGLTGDGSt-LKDLELPESVKKVSIYGDYHSINVAKQIfKNVLELEF 330 Mycoplasma pneu...
WP_014894651 241 VKTLAIDAKDISA-----LKTTIDSEKPTYLIIRGLSGNGSq-LNELQLPESVKKVSLYGDYTGVNVAKQIfANVVELEF 314 Mycoplasma geni...
WP_014885954 224 IFTMSIDLYQANPa---MINETLKEYSPDFVILS--NADSQt-MKQLVFPSSVKKLTIKSNILDRFDFSLVnSEIQELEL 297 Mycoplasma gall...
WP_011076965 201 QLYVALDSKTMTAd---VITKLVDRYQPDYLRIESVDDTSIkqLPDMKYFSTVKKVDLGGAFTTIKGVSFP-TTTQELKI 276 Mycoplasma pene...
WP_004025288 267 YLG--S--SLKSIDPLIFPKSANIISDVVMNntsSVFTEIKLSDSTIDNN------SPKLQEAIDDVYTYRIKERAFQGL 336 Mycoplasma iowae
WP_010874756 331 YSTnqD--NNFGFNPLVLGDHTNIIYDLFAS---KPFNYIDLTSLELKDNqdn-idASKLKRAVSDIYIRRRFERQMQGY 404 Mycoplasma pneu...
WP_014894651 315 YST--SkaNSFGFNPLVLGSKTNVIYDLFAS---KPFTHIDLTQVTLQNSdnsaidANKLKQAVGDIYNYRRFERQFQGY 389 Mycoplasma geni...
WP_014885954 298 YTP-----NLTEYNPLALNPKTHLISDTDYS---TRFLSINLYGAQLTN--------QQALVALEDVFVRRYYERALQGS 361 Mycoplasma gall...
WP_011076965 277 SSD-----NIKSIDPLQIPESAAIITETVHD---ARFTEIDLSSHTDLT-------TDQLQKAVNIVYKDRIKERAFQGN 341 Mycoplasma pene...
WP_004025288 337 VPGGYIASWDLTGTKVTSFNN------VNIPPLNDGTGRFYIAHVEVKTDGNFGNSQNESIGS--KPSNDSQINDWFDWG 408 Mycoplasma iowae
WP_010874756 405 WAGGYIDRYLVKNTNEKNVNKdndtvyAALKDINLHLEETYTHGGNTMYRVNENYYPGASAYEaeRATRDSEFQKEIVQR 484 Mycoplasma pneu...
WP_014894651 390 FAGGYIDKYLVKNVN-TNKDSdddlvyRSLKELNLHLEEAYREGDNTYYRVNENYYPGASIYEneRASRDSEFQNEILKR 468 Mycoplasma geni...
WP_014885954 362 FVGGYISSLVLSDTGITSLNN------LVIKNINPNYDSYTMSVKYHSNDSGQIELLKTTAWEtpTPTPD--------QA 427 Mycoplasma gall...
WP_011076965 342 FAGGYIYSWNLQNTGITSFND------VSIPKLNDGTDRFYIAYVAVSS-GNSNGTANETITGgkEPSNDSQIGEWWDSS 414 Mycoplasma pene...
WP_004025288 409 G-GWQKVQEVVVSSSE--NVSLETATQEIMG-------------FIAKYPNVKKINIVNVKLTDG-STHEQLKDNVIKAI 471 Mycoplasma iowae
WP_010874756 485 AeLIGVVFEYGVKNLRp-GLKYTVKFESPQEqvalkstdkfqpvIGSVTDMSKSVTDLIGVLRDN-AEILNITNVSKDET 562 Mycoplasma pneu...
WP_014894651 469 AeQNGVTFDENIKRITa-SGKYSVQFQKLENd-----------tDSSLERMTKAVEGLVTVIGEEkFETVDITGVSSDTN 536 Mycoplasma geni...
WP_014885954 428 AaPGDGRVNVEDKDLRl-LVSSEVPVN--------------------AEVLINVVS--KYLYNNTrVNILDISKSLLKSG 484 Mycoplasma gall...
WP_011076965 415 SdGWSKVSKVTVTAKNgaSLDYNKTLTEIMG-------------FLAKYPNVKTIDISLLKFEDAsKTLDGLKTELTNQI 481 Mycoplasma pene...
WP_004025288 472 TAKYGEESQYKDIEFVLPE 490 Mycoplasma iowae
WP_010874756 563 VVAELKEKLDRENVFQEIR 581 Mycoplasma pneumoniae
WP_014894651 537 EVKSLAKELKTNALGVKLK 555 Mycoplasma genitalium
WP_014885954 485 SLVDVANSLKAKIPYLNVV 503 Mycoplasma gallisepticum
WP_011076965 482 KSKYGEDSSYAKIDFIITS 500 Mycoplasma penetrans
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