Conserved Protein Domain Family
CGA_synth_rel
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TIGR04469: CGA_synth_rel 
CGA synthase-related protein
Members of this family are related to cytosylglucuronate (CGA) synthase (TIGR04466), and found in the same clusters as CGA synthase and CGA decarboxylase. These clusters produce peptidyl nucleoside antibiotics with a pyranoside core moiety, found in a number of Streptomyces species. Removal of the S. griseochromogenes member of this family, BlsF, from a heterologous expression system caused an increase, not blockage, of blasticidin S. [Cellular processes, Toxin production and resistance]
Links
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Statistics
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PSSM-Id: 275262
Aligned: 5 rows
Threshold Bit Score: 182.791
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_020556025  36 ILLVSRDDRLDSVLARRRVAAHLGGLRALR--DS----------TGQPLPDVALVCDDEAATERLLESGVPVVHLSs-GH 102 Streptomyces sc...
AFD20752      30 IALRFAPADVEAAAAAEYVAAHLGGFRCLP--ECpqeg---dsgPGRNPPAAVIVFGRSGAAGGAGPAGVPTVLVE--GA 102 Streptomyces ri...
AGG35697      14 VLAAALPDDPESQTVLGWICAHLTEVELLPgqEPgst----gaqSPDAPARVAVICDDTALAEHTERAGTAVVFVSstGV 89  Streptomyces ar...
WP_006348430   1 MLLSAREDQLDSTLALGRVAAHLGDLRRTD--RS----------EPEPPPVAALVCDDVTATERLLTLGVPVVHLQs-GP 67  Streptomyces ts...
AAP03120      21 LLLVADPRRLDSLTARRRVAAHLREMDLVV--EAgsteeqgwigKDADRPDAALVCDLPGAAQALTGRGVPVVHLHs-GY 97  Streptomyces gr...

WP_020556025 103 HGttgTTGTTgttgtsgagttaatgaagRALHRVHRPGWLPDPalsstGPRRNGVRPTG---------LLAPARSARKRE 173 Streptomyces sc...
AFD20752     103 EP---VPGTD------------------ADVVCRQAPGWLTAGe----PPAPPAVRPGGgrirtvdvaAVAPFRQVRSGG 157 Streptomyces ri...
AGG35697      90 PPtngWPA--------------------ARIRSMHRPGWLP-------GERHQGVHQAG---------TVAPPRAVRARN 133 Streptomyces ar...
WP_006348430  68 AGe-aLPG--------------------RVLVRVHRPGWLPLP-----GPPARGARPTG---------VLAPRRTGRSPN 112 Streptomyces ts...
AAP03120      98 RSt-eLPAVT------------------AAVVRAHAPAWLPA------PRSPAGTRPAG---------LLAPARLVRDRT 143 Streptomyces gr...

WP_020556025 174 RAG-TLLLLSAWDVPDAEANAFIADTLPAlvreALRR--TGRCDVVGDTrlTPIRAALAG--LAGRREVRVSRAVDV--- 245 Streptomyces sc...
AFD20752     158 GGGrAALLLGGAGGPDGSGASAGGEALPG----ALARfiAGHPAAAGDA--WAVLTDLTGepLRELLGLLPPTARTVgaa 231 Streptomyces ri...
AGG35697     134 GRG-ALIRLA---VPEAADPADSTRLLRTaq-dALAE--AADCPVFAVHlyGPGSARATGtvTALLPGATVYQDRDP--- 203 Streptomyces ar...
WP_006348430 113 RSG-TLVLLSLWGVPPAEAEAFASEALRElvaaALRR--TGSCTVVADT--GLALVRSA---LAEHRGVRVLRAAGA--- 181 Streptomyces ts...
AAP03120     144 RAG-CLLLVSAYQVPGHDLTAFADGLLRAvaeeAVRR--TGRCEVVCD-----GEAASTAavLTGTAGVRVHDARSV--- 212 Streptomyces gr...

WP_020556025 246 DVDALHAGAEVFLAAPTLGALALAQARRAPLVFLPALGDTQRdl------------------aACVRHLVPVPPA-DDPE 306 Streptomyces sc...
AFD20752     232 DWAQVLRRADSLVATPTLLAAAHARTARIPLHVLDPAGPAQR---------------------RVHRALAAIAGApGEPG 290 Streptomyces ri...
AGG35697     204 AAERALSEASLLVSSPALTSVTLAQTARIPLALLPPLGAHQQraaavldsagaplavlggdhaRRTDEAEALRRAlDAPD 283 Streptomyces ar...
WP_006348430 182 DPDALHADAAVLLASPVLGAIALAQARRAPLALLPPLGPHQRal------------------aAQVREILPLPSA-DDPD 242 Streptomyces ts...
AAP03120     213 DVDALHAAADVFVASPTLTALTLAQSLRTPLALLPPLDHDQDdl------------------aRHARQAVRVPTV-TDPA 273 Streptomyces gr...

WP_020556025 307 DDALWAPPErnatalWSVLDPDLDDLRGAQRVARTLRQLSLAPL 350 Streptomyces scabrisporus
AFD20752     291 GLPVVGPDD------WPRDDGRAGALGGAAQIARQVRQLCLAPA 328 Streptomyces rimofaciens
AGG35697     284 ELAHWADAAqqa---------agDDRRGAQRIARKVRQLLLAPM 318 Streptomyces arginensis
WP_006348430 243 DPGLWSPEAaa--gpWHLLDPGLDDLRGAQRVARTLRQLALAPL 284 Streptomyces tsukubaensis
AAP03120     274 DPALWAPSDadarsaWAALDS--DDLRGAQRVARTLRQLALAPI 315 Streptomyces griseochromogenes
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