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type I toxin-antitoxin system toxin TisB Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics. [Cellular processes, Adaptations to atypical conditions] |
Jiyao W et al.(2023). "The conserved domain database in 2023.",