Conserved Protein Domain Family
no_iron_rSAM
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TIGR04419: no_iron_rSAM 
HemN-related non-iron pseudo-SAM protein PsgB
Members of this protein family are related to radical SAM enzymes HemN (oxygen-independent coproporphyrinogen III oxidase) and HutW (a putative heme utilization enzyme) but lack the signature CxxxCxxC motif for 4Fe-4S binding. Members occur exclusively in Borrelia, which appears to live without iron, as the only radical SAM enzyme homolog in any Borrelia genome. We designate this enzyme PsgB (Pseudo-SAM, Genus Borrelia).
Links
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Statistics
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PSSM-Id: 275212
Aligned: 4 rows
Threshold Bit Score: 536.306
Created: 10-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012539066   2 NFLSLKELSIYIDFSKCF-SHIFYEKVFRELSYYLEVLGFPKVKTLYIKYNDLRLVDVFELKSFLTSLSAKFNFFDLDEF 80  Borrelia recurr...
WP_012422406   2 NFLCLTDLSIYIDLTRCF-SYVFFNKILHELSCCLEVLGFPKIKTLYIKYETLGFGNDANLESFLTSLSKNFDFVTLDEF 80  Borrelia hermsii
WP_011772591   2 NFLRLTDLSIYIDLTKCF-SYVFFDKILQELSYYLKVLGSPQIKTLYIKYETSGLGNDSDLESFLTSLSQNFDFLTLDEF 80  Borrelia turicatae
WP_014653833   4 DLLPLFELSLYINMSFCCkDFSIFNRILGELKYYLTLLGHPIIKTLYIKHVDFCLCRQDSLKFIFTSLSKYINLALLEEF 83  Borrelia garinii

WP_012539066  81 TFELHPGNITTSVLTVLDNFFVSRISLDIKSFSSKFLEKIGIFGVSIDKVNAAIENIHQFHFDLNIDFDINILYHNKTNL 160 Borrelia recurr...
WP_012422406  81 TFELHPGEITPSLLTILNDFSVSRISLDVKSFSSKFLRILGASWISVGRVNIAVDNIHKFDFDLNIDLSINIPYQEKMHL 160 Borrelia hermsii
WP_011772591  81 TFELHPLEITLSLLAILNDFSVSRISIDIKSFSSKLLKVMGVYEISVAEINNAVNGIRKFDFDLNIDLNVNIPYQEKMHL 160 Borrelia turicatae
WP_014653833  84 TLEIIPGHVDFEKFKLLDEFFITRINLTVQSFSLKFRKILGIPEISYEKMNILIKNIRKFPFDLNIDMTINIPLQKKSDL 163 Borrelia garinii

WP_012539066 161 KSDLVKVISYAPEHISLSEVLIDKNNCIVDSSSDAYSDYNDIRGEDLWFYAFDFLESHGYLNYEISNFALRGYECKHNVR 240 Borrelia recurr...
WP_012422406 161 KSDLVKVIACAPEHICLSEVLVDEENCNIELFKEVSCNYDEAKAEYFWFYALDFLESSGYINYEISNFALKGHESKHNAR 240 Borrelia hermsii
WP_011772591 161 RNDLVKLVACAPEHICLSEILVDGENCIIDFFKDVSSNYNEAKAEDFWFYAFDFLESNGYMNYEISNFALKGHESKHNLR 240 Borrelia turicatae
WP_014653833 164 KRDLKELLSYIPEHICFSDFICEEQDLTLRDFD------SGIDSEKLWFYALECLESNSYINYEITNFMLKGHESKHNKL 237 Borrelia garinii

WP_012539066 241 YWELSPYLGLGLQAVSLLFVS-ENNGLRAVIRKDDNFLYSVESSATFENLSDLDFFIYHFITNLGTKRGLDISILRRRFI 319 Borrelia recurr...
WP_012422406 241 YWALKPYLGLGINSVSLLVAH-KGDGLEAVIRRDDNFLGSPRASATFESLSDLDFFICHFITNLGTKNGLDVSILKRRFI 319 Borrelia hermsii
WP_011772591 241 YWELKPYLGLGVNSVSLLVIS-KGDGLKAVIKMDDNFLGVGKSTAAFEILSDLDFFICHFITNLGTKKGLEVSVLKRRFI 319 Borrelia turicatae
WP_014653833 238 NWELKPYLGLGLHAVSLLFCNdKNNNARALIRKDSGFVKASNHLAKFELLEDLEFFIYHFIQGLGTIQGVNLRSLRLRFE 317 Borrelia garinii

WP_012539066 320 YHQNDFYKFIDYLLSLNKSVVLSNDILYLEQCERFKLNFYLRLIEEYFIVNSFKVSFKFL 379 Borrelia recurrentis
WP_012422406 320 YNQENFYKLIDYLLSLSKSVVFSNDILYLDGHERFKLDFYLRLIREYLINNSFKVNFKFL 379 Borrelia hermsii
WP_011772591 320 YNQEDFCNFINYLLRLSKGVVFSNDILYLDGHERFKLDFYLRLIREYLVSNSFKVNFKFL 379 Borrelia turicatae
WP_014653833 318 YNDKQFFQFINYCSNLSKKFVFDNNIMLLKGRERFKLDFYLLKIINYFNDNFFKVKFRLP 377 Borrelia garinii
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