Conserved Protein Domain Family
rSAM_skfB
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TIGR04403: rSAM_skfB 
sporulation killing factor system radical SAM maturase
Members of this family are a radical SAM enzyme of post-translational modification of ribosomally translated peptides. In Bacillus subtilis, the enzyme SkfB creates a sactipeptide (sulfur-to-alpha-carbon) crosslink of Cys-4 to Met-12 of the mature form of sporulation killing factor (SkfA). In Paenibacillus larvae subsp. larvae B-3650, the Met is replaced by Leu, so the modification must be different. SkfB has 2 4Fe-4S clusters, one in its radical SAM domain (pfam04055) and one in a region that somewhat resembles the SPASM domain (TIGR04085).
Links
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Statistics
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PSSM-Id: 275196
Aligned: 3 rows
Threshold Bit Score: 784.114
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ZP_10162759    4 NQLAEYDLPELAIHLQPHGAVMIDRKSMYYFRLSGRGAQLAFLLSKNKDVSKTARIWEIVKKEELTADQLREELSAHPFT 83  Bacillus sp. M 2-6
ZP_09072123    3 TETEQQAGPEFFIHLQPQGALLVEKRSMYYFRLSGEAVEIALLLARNKSIRRTANILSMTKGSKITEEDLLAQLSAHPLT 82  Paenibacillus l...
WP_003234902   4 DRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAFLLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFT 83  Bacillus subtilis

ZP_10162759   84 EAWTQGlLNQPIQFTGSLQSYLPISCTLQLTNACNLGCSFCYASSGKPYPEELTCSQWINVMQKLAAQGVADVTLTGGEA 163 Bacillus sp. M 2-6
ZP_09072123   83 DTWKNG-IEGRLPVYGSTRSYVPISCTLQLTNGCNLSCSFCYASSGKRLENELATDEWLQILKKLAAVGVNDVTLTGGEA 161 Paenibacillus l...
WP_003234902  84 EAWTEGlLDQPLHVSGSLDSYLPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA 163 Bacillus subtilis

ZP_10162759  164 KLIKGFKEIVMVASSLFTNVNVFSNGLNWRQEEVELLSHLGNVSVQISIDGTSDTHNSLRGRKGAFQESMETIQRLTEVN 243 Bacillus sp. M 2-6
ZP_09072123  162 RLAKGFKHILTAASSLFTSVHLFSNGLNWRDDEIELIQNLGNVFVQVSIDSTPEIHNLLRERQGAYEETFNNIKRMASAH 241 Paenibacillus l...
WP_003234902 164 KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQLRGRKGGFKESMNTIKKLSEAN 243 Bacillus subtilis

ZP_10162759  244 VPVIVAMTINEMNADQVAEVVDHCAKANASIFRAGKTLSVGRAtKNFK-ALETSFEQRVQSQLQQARSKWGHHLNIIDWE 322 Bacillus sp. M 2-6
ZP_09072123  242 INCLVAMTVNPKNFHTVKDVVKDSVNAGARIFRAGITLPAGRA-EGFSfGLTDEQYSCVNQQLKESSRLYGDQIYISNWE 320 Paenibacillus l...
WP_003234902 244 IPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTLSVGRAtEGFK-ALDIDFEEMVQIQLREARHKWGDRLNIIDWE 322 Bacillus subtilis

ZP_10162759  323 HEESSFTTDFCTPGYLAWYIRADGYVTPCQLEDIPLGHILTDSFSDIGSPTRLLKLKCEAKNCKCIGKVELSEP-DLPFE 401 Bacillus sp. M 2-6
ZP_09072123  321 EDDHDGCTDFCTPGYLQWYIRADGVVTPCQVESESLGHILRDSIGDIGNPERLKRVKETAKSCNCIRKVKLPEDvDLPYI 400 Paenibacillus l...
WP_003234902 323 HEESSFTTDFCTPGYLAWYIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEP-DLPFQ 401 Bacillus subtilis

ZP_10162759  402 NEMR 405 Bacillus sp. M 2-6
ZP_09072123  401 YTGK 404 Paenibacillus larvae subsp. larvae B-3650
WP_003234902 402 KEVK 405 Bacillus subtilis
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