Conserved Protein Domain Family
choline_CutC

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TIGR04394: choline_CutC 
choline trimethylamine-lyase
Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
Statistics
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PSSM-Id: 275187
Aligned: 10 rows
Threshold Bit Score: 1650.69
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_06114526         42 ITERLQLLKENYLKQVPSITTYRARAITKIAKENPGMPKILLRAKCFRYCCETAPLVIQDHELIVGAPCGAPRAGAFSPD 121  Clostrid...
ZP_08170365         61 PTQRLVDLKANFLKQVPTITLHRAKIVTELTRENPGMPKNVLRAKAFRKNCETAPLVIQDNELIVGSPCGAPRSGAFSPD 140  Anaeroco...
REF_jgi:Pcar_0937   20 LPERIQRLKDAYLQVKPSIAIGRALAFTEVTRQNPGMPEILRRALAFKKACEDAPLLIQTDELIVGHPCGKPRAGAFSPD 99   Pelobact...
WP_011189064        58 PTDRHIKLKKKFLTHVPTITTHRARAITKIAQENPGLPKAILRGKSFKYCCETAPLVIQDNELIVGSPCGAPRAGAFSPD 137  Desulfot...
WP_015850354        60 PTDRHVKLKENFLKQVPSVSVESARVMTEMAKANPGLPPAILRGKSFRASCEQAPLVIQDHELIVGNPTGAPRRGSFSPE 139  Desulfov...
WP_012624983        60 PTQRHVLLKENYLKQVPRITIHRARTITKIDKENPGMPRILLRATAFRHCCESAPLIIQDHELIVGAPNGAPRAGAFSPE 139  Desulfov...
WP_012064911        57 ITERLKTLKDNYLKWKPSISIHRARAITKIAKENPGMPKILLRAKSFRYCCETAPLVIQDHELIVGAPCGAPRAGAFSPD 136  Alkaliph...
WP_013251182        59 PTDRQVRLKENFLKQVPSITMYRARAVTEIMKANPGMPRIELRAKAFRRCCETAPLVIQDDELVVGAPCGAPRAGAFSPD 138  Olsenell...
WP_011879563        59 LTPRLERLRANYLKVKPSVSIYRAIAFTQVTKENPGLPKILLRAKCFRKACETAPLVIQKDELIVGHPCGKPRAGAVSPD 138  Desulfot...
WP_001328324       352 LTPRIQRLRNHYLTVRPSVSIYRALAFTEVVKANPGMPTILLRAKAFRHACETAPILIQDDELIVGHPCGKPRAGAFSPD 431  Escheric...
ZP_06114526        122 IAWRWMEDEIDTIGTRAQDPFYISEEDKKIMREELFPFWKGKSVDEYCEDQYREAGVWELSGESFVSDCSYHALNGGGDS 201  Clostrid...
ZP_08170365        141 ISWRWLRDELDTIENRPQDPFHISEEDKQYCKDVLFPFWEGRSLDEVCEDQYRDAGVWELSGESFVSDCSYHQVNGGGDS 220  Anaeroco...
REF_jgi:Pcar_0937  100 IAWKWVRDELDTIGTRSQDPFVFSEEDKKIMREEIFPFWEGRSLDEICETQYREAGLWEFAAEAFVSDLSYHQVNGGGDT 179  Pelobact...
WP_011189064       138 IAWRWVKDELDTIGTRPQDPFFISEEDKKIMREELFPFWEGRSIDEYCEQQYREAGMWELSGESYVTDCSYHATNGGGDS 217  Desulfot...
WP_015850354       140 IAWRWMKDELETIGSRPQDPFYISEEDKKYMKEELFPFWADKSIDEYCEAQYREAGLWELSGESYVSDCSYHAVNGGGDS 219  Desulfov...
WP_012624983       140 ISWRWLRDELDTIDSRAQDPFHLAEEDKKILCEEIFPYWAGKSVDEYCEAQYREAGLWELSGESYVSDCSYHALNGGGDS 219  Desulfov...
WP_012064911       137 ISWRWLEEELDTIANRSQDPFYISEEDKKELVEEIFPYWKGKSVDEHSEDQFREAGVWEISGESFVSDCSYHALNGGGDS 216  Alkaliph...
WP_013251182       139 LAWRWLRDELDTIGERPQDPFYISEEDKQYCRDVLFPFWEGKSQDEVCEDQYREAGVWTLSGESFVSDCSYHAMSGGGDS 218  Olsenell...
WP_011879563       139 IAWRWIRDELDTMSTRPQDPFEISEEDKRILREEIFPYWEGKSLDEVCQNQYEEAGLWSFTGEAFVSDLSYHQVNGGGDT 218  Desulfot...
WP_001328324       432 IAWRWVRDELDTMSTRPQDPFEISEEDKKTIREEIVPFWEGRSLDEICEAQYREAGVWSFSGETFVSDLSYHQVNGGGDT 511  Escheric...
ZP_06114526        202 NPGYDVILMKKGMLDIQREAKEHLEQLDYENPDDIEKIYFYKSIIDTTEGVMIYAKRLSEYAAELAAKEADPKRKAELLK 281  Clostrid...
ZP_08170365        221 NPGYDVILMKKGMKDIQQEAKDHLEKLDYSNPEDIDKIYFYKSVIETTEGVMIYAKRLSEYAKQLAQKETNPKRKMELEK 300  Anaeroco...
REF_jgi:Pcar_0937  180 CPGFDVILFTKGVSGIKAEAEAHLAKLSMDVPDDIDRIYFYKAAIQTCEGIVTYANRVSAYAKELAEKEQDPKRKAELEK 259  Pelobact...
WP_011189064       218 NPGYDVILMKKGMLDIVRESQEKLAELDYENPDDMDKIYFYKSLIDTAEGVMIYAKRLSDYAAQLAASEKDPQRKAELEK 297  Desulfot...
WP_015850354       220 NPGYDVILMKKGMLDIKAEAEAHLEELDYENPEDIDKIYFYKSVIDTAEGVMIYAKRLSEYAAQKAAQETDPKRKAELLK 299  Desulfov...
WP_012624983       220 NPGYDVILMKKGMLDIQREAREHLEQLSYDRPEDIDKIYFYKSVIETTEGVMIYARRMSEYAAQLAARENDPRRKAELLK 299  Desulfov...
WP_012064911       217 NPGYDVILMKKGMLDIQEEAKEKLNELSYENPEDIEKIYFYKSVIQTTEGVMVYARRLSEYAMELAQKESNPNRKAELMK 296  Alkaliph...
WP_013251182       219 NPGYDVILMRKGMLDIQEEAKQHLAQLDYANPDDLDRIYFYKSVLDTTEGVMIYAKRMSDYAAKLAGECHDARRKAELEQ 298  Olsenell...
WP_011879563       219 CPGYDIILIKKGINGVRQEAVERLSKLSMENPEDIDKIYFYKAEIETCDGILAYAKRLSDYARELAAREHDANRQKELYK 298  Desulfot...
WP_001328324       512 CPGYDVLLFTKGMNGIKADAEAHLAELSMENPEDIDRIYYYKAAIDTCEGVINYAHRIAARARELAAVEQNAQRRAELLT 591  Escheric...
ZP_06114526        282 ISEVNARVPAHKPETFWEAIQAVWTIESLLVVEENQTGMSIGRVDQYMYPFYKGDIESGRLNDFQAFELAGCMLIKMSEM 361  Clostrid...
ZP_08170365        301 IAEVNAYVPANKPRTFWEAIQAVWTIESLLVVEENQTGMSIGRVDQYMYPFYKADIESGRMNDYQAFELAGCMLIKMSEM 380  Anaeroco...
REF_jgi:Pcar_0937  260 IAEVNARVPANPPSSFQEALQSIWTIESLFVIEENQTGLSLGRLDQYVYPCYEADIKAGVIDEDQAFELMSCFIIKCAEM 339  Pelobact...
WP_011189064       298 ISAVNARVPAHKPETYWEAIQAVWTVESLLIVEENQTGMSIGRVDQYMYPFYKADIEAGRMTEYEAFDLSGCLLVKCSEM 377  Desulfot...
WP_015850354       300 ISEVNARVPAHKPETFWEAIQAVWTVESLLVVEENQTGMSIGRVDQYMYPYFKADLEAGRLTEYEAFDLAGCMLIKMSEM 379  Desulfov...
WP_012624983       300 IAEVNARVPAHAPTTFWEAIQAVWTVESLLVVEENQTGMSIGRVDQYMYPFYKADIEAGRMTPYEAFDLAGCMLIKMSEM 379  Desulfov...
WP_012064911       297 IAEVNKRVPAHKPNNFWEAIQSVWTVESLLVVEENQTGMSIGRVDQYMHPFFEQDLKNGNLSEYEAFELAGSMLIKMSEM 376  Alkaliph...
WP_013251182       299 ISKILAYVPAHRPRTFWEAVQSVFVIESLLPVEENQTGMSIGRVDQYMYPFYKADIEAGRITPYQAFDIAGCMLIKMSEM 378  Olsenell...
WP_011879563       299 ISDILTHVPANPPRTFHEALQSIWTLESLFVVEENQTGISLGRLDQYIYPMFKADMDAGRMNKLEAFELLSCFIIKCSEV 378  Desulfot...
WP_001328324       592 IAEVNQNVPANPPKTLQEALQSIWTVESLFEIEENQTGLSLGRVDQYCYPMFEADIREGRLTHEGALELMQAFIIKCAEL 671  Escheric...
ZP_06114526        362 MWITSEGGSKFFAGYQPFVNMCVGGVTRDGRDATNDLTYLLMDAVRHVKIYQPSLACRIHNKSPKKYMKKIVDVIRSGMG 441  Clostrid...
ZP_08170365        381 MWLTSEGSSKFFAGYQPFVNMTIGGVTREGVDATNDLTYLLMDAVRHVKVYQPSLATRIHTKSPEKYLRKIVDVVRAGMG 460  Anaeroco...
REF_jgi:Pcar_0937  340 MWLTSELAAKYFAGYQPFINLCVGGQKREGGDATNDLTYLVMDVVRKLGVYQPSLACRIHNQSPQKYLQKIVEVVKAGLG 419  Pelobact...
WP_011189064       378 MWITSEDASKFFAGYQPFVNMCLGGVTREGLDATNDLTYLLMDAVRHVKVYQPSVSTRVHNQSPQKYLKKIVDVIRAGMG 457  Desulfot...
WP_015850354       380 MWITSEDASKFFAGYQPFVNMCVGGVTREGYDATNDLTYLLMDAVRHVKIYQPSLATRVHNKSPHAYLKKIVEVIRSGMG 459  Desulfov...
WP_012624983       380 MWLTSEGSSKFFAGYQPFVNMCVGGVSREGRDATNDLTYLLMDAVRHVRIYQPSLATRVHNTSPQEYLKKIVSVIRSGMG 459  Desulfov...
WP_012064911       377 MWLTSEGSSKFFAGYQPFINMCVGGVTREGLDATNDLTYLLMDAVRHVKIYQPSLATRIHSKSPKKYLRKIVDVVRSGMG 456  Alkaliph...
WP_013251182       379 MWVTSRGQSEFFAGYQPFVNMTLGGVTRQGHDATNELTYLLMDAVRHVKVYQPSVACRINNKSPEKYMRKIVDIVRSGMG 458  Olsenell...
WP_011879563       379 MWLSSELGAKYFAGYQPFVNCTVGGQKRTGGDATNDLTYLIMDAVRFTKMYQPSLACRIHNKSPQKYLKKIVDVVKAGLG 458  Desulfot...
WP_001328324       672 MWMSSELGAKYFAGYQPFINLTVGGQKRSGGDACNDLTYLIMDAVRFVKVYQPSLACRIHNQSPQKYMEKIVDVVKAGMG 751  Escheric...
ZP_06114526        442 FPACHFDDAHIKMMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPVCIELVLNHGVPLWYGKQVCPDMGDLS 521  Clostrid...
ZP_08170365        461 FPACHFDDTHIKMMLAKGVSVEDARDYCMMGCVEPQKSGRLYQWTSTSYTQWPIAIELTLNHGVPLWYGKQVTPDLGSLS 540  Anaeroco...
REF_jgi:Pcar_0937  420 FPACHFDDAHIKMMLRKGYDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPVAIEFVLNRGVMKWHGTKQGIDTGDLD 499  Pelobact...
WP_011189064       458 FPAIHFDDAHIKIMLAKGCSIEDSRDYCLMGCVEPQKSGRLYQWTSTAYTQWPICIEMALNHGVPLWYGKQVCPDLGALE 537  Desulfot...
WP_015850354       460 FPAVHFDDAHIKMMLAKGVSMEDARDYCLMGCVEPQKAGRLYQWTSTAYTQWPICIELVMNHGVPLWYGKQVCPDFGPLE 539  Desulfov...
WP_012624983       460 FPAVHFDDTHIKMMLAKGVDIEDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPICIELVLNRGVPLWYGKQVCPDLGDLS 539  Desulfov...
WP_012064911       457 FPACHFDDVHIKMMLAKGVSIEDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPICIELALNKGIPLWYGKKVCPDTGDVD 536  Alkaliph...
WP_013251182       459 FPACHFDDSHIKMMLAKGVSVEDSRDYCMMGCVEPQKSGRLYQWTSTSYTQWPICIELTLNHGVPLWFGKQVTPDLGDPS 538  Olsenell...
WP_011879563       459 FPACHFDDSHIKMMLAKGFGIEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLRRGIMKWHGTLQGIDTGDLD 538  Desulfot...
WP_001328324       752 FPACHFDDSHIKMMLRKGFDFEDARDYCLMGCVEPQKSGRIYQWTSTGYTQWPIAIEFVLNRGRMVLFDSYQGLDTGDLK 831  Escheric...
ZP_06114526        522 RFKTFEEFDAAVKEEIKYVTKWTDVATVISQRVHKELAPKPLMSIMYEGCMEKGKDVSSGGAMYNYGPGVVWSGLATYTD 601  Clostrid...
ZP_08170365        541 NFDTWEKFEKAVKEQISYITKLTAAATTISQRVHRDMAPKPLMSVMYEGCMEHGKDVSAGGAMYNFGPGVVWSGLATYAD 620  Anaeroco...
REF_jgi:Pcar_0937  500 QFATYEQFDAAVKEQIEYICKLSAVGTVISQRVHRDVAPKPMMSLFVEGCMETGKDVSAGGAVLNHGPGLIFSGLATYAD 579  Pelobact...
WP_011189064       538 SFDTYEKFDAAVKEQIKYVTKWTSVGTVISQRIHRDLAPKPLMSMMYEGCMESGKDVSAGGAMYNFGPGVVWSGLATHAD 617  Desulfot...
WP_015850354       540 NYDTYEKFEAAVKEMIKYITKWTSVATVISQRVHRDHAPKPLMSLMYEGTMESGLDVASGGAMYNFGPGVVWSGLATYAD 619  Desulfov...
WP_012624983       540 QFDTFEKFDAAVKEQIRYITKWSSVATVISQRVHRDLAPKPLMSIMYEGCMEKGRDVAAGGAMYNFGPGVIWSGLATYAD 619  Desulfov...
WP_012064911       537 GFASYEDFEKAVKEQINYITKLSSIATVITQRVHRELAPKPLMSIMYEGCMEKGKDVSSGGAMYNFGPGVVWSGLATYVD 616  Alkaliph...
WP_013251182       539 QYKTYEEFDEAVKKTIYYVTKWTDVATVISQRVARDVAPKPLMSIMFEGCMESGKDVSAGGAMYNYGPGVVWTGLATYAD 618  Olsenell...
WP_011879563       539 NFKTYEEFDAACKKQIEHIIRMSAIGTIISQRVHRELAPKPLMSLLVEGCMEKGTDVTHGGALVNSGPGLIFSGLGTYAD 618  Desulfot...
WP_001328324       832 DLRTFEDFDAAVKKQVAHIIRLSAIGTVISQRVHRDVAPKPLMSLLVEGCMEKGKDVSAGGAMVNHGPGLIFSGLATYVD 911  Escheric...
ZP_06114526        602 SMAAIKKLVFDDKKYTLEQLNEALKADFVGYDQIKADCLNAPKYGNDDDYADLIAADLVDFTEAEHRKYKTLYSHLSHGT 681  Clostrid...
ZP_08170365        621 SMAAIKKLVYDDKKYSLEQLNEALKAEFKGYDQIKRDCLDAPKYGNDDDYADSICNDIINFTEREHAKYRTLYSRLCHGT 700  Anaeroco...
REF_jgi:Pcar_0937  580 SMASIKKLVYDDKKYTLADFQKALDANWEGYEQMRQDCLDAPKYGNDDDYADKIAADLVEFTEKACRQFKMLYSTMSHGT 659  Pelobact...
WP_011189064       618 SMAAIKKLVFDDKKYSLTQLNEALKAEFKGYDQLKADCLAAPKFGNDDDYADLIVNDLVNFTEREHRKFKTLYSVLSHGT 697  Desulfot...
WP_015850354       620 SMAAIKKLVYDDKKYTLAQMNEALVAEFKGYDQIKADCLAAPKYGNDDDYADMIAADLVHFTETEHRKYKTLYSVLSHGT 699  Desulfov...
WP_012624983       620 SMAAIKKLVYDDRKYTLQQLNEALKANFEGYDAILADCLAAPKYGNDDDYADDIAADLIAFTEREHRKYRTLYSILSHGT 699  Desulfov...
WP_012064911       617 SMAAIKKLVFDEKKYTFKQLNEALNKDFEGHEELRNDCLKAPKYGNDDDYADLIAVDLVNYTENEHRKYKTLYSVLSHGT 696  Alkaliph...
WP_013251182       619 SMAAIKKLVFEDHKYTLTQLFDAMKADFEGFEQLRKDCLDAPKYGNDDDFADSIAADIVDYTEHIHLDFKTLYSHMSTGT 698  Olsenell...
WP_011879563       619 SMAAIKKLVFDDKKYTLKQIRDALDANFEGYETIRTDCLNAPKYGNDDDYVDEIAADLITWTERVHNTFKMLYSHFSHGT 698  Desulfot...
WP_001328324       912 SMAAIRKLVYEDKKYTLEQIRDALLANFEGYEGLRRDCLNAPKYGNDDNYVDQYALDITEWTERECRKYKMLYSTLSHGT 991  Escheric...
ZP_06114526        682 LSISNNTPFGQMTGASANGRGAWLPLSDGISPTQGADYKGPTAIIKSVSKMANDSMNIGLVHNFKIMAGLLDTPEGEESL 761  Clostrid...
ZP_08170365        701 LSISNNTPFGQMTGASANGRDAWTPLSDGISPTQGADFNGPTAIIKSVSKMANDSMNMGMVHNFKIQKGILDSIEGENAL 780  Anaeroco...
REF_jgi:Pcar_0937  660 LSISNNTPIGEITGATADGRLAFTPLSDGISPVQGADKMGPTAIIKSVSKMNSESMNIGMVHNFKLMEGILETPEGEAGL 739  Pelobact...
WP_011189064       698 LSISNNTPFGQLLGASANGRDAWMPLSDGISPTQGADFKGPTAIIKSVSKMPTDSMNIGMVHNFKLMSGLLDTPEGENGI 777  Desulfot...
WP_015850354       700 LSISNNTPFGQLLGASANGRDAWMPLSDGISPTQGADYKGPTAVIKSVSKMANDLMNIGMVHNFKIMSGLLDTPEGENSI 779  Desulfov...
WP_012624983       700 LSISNNTPFGQLLGASAGGRKAWQPLSDGISPTQGADYKGPTAIIKSVSKMSNDNMNIGMVHNFKLMPGLLDTPEGEQGI 779  Desulfov...
WP_012064911       697 LSISNNTPFGQLTGASANGRKAWAPLSDGISPTQGADFKGPTATIKSVSKMACDNMNIGMVHNFKLMSGLLDTPEGEEGI 776  Alkaliph...
WP_013251182       699 LSISNNTPFGEMTGASANGRKAWTPLSDGISPTQGADFRGPTAIIKSVSKLSNDSMNIGMVHNFKLMSGLLDTPEGENGL 778  Olsenell...
WP_011879563       699 LSISNNTPIGEITGASANGRLAWAPLSDGISPTQGADKLGPTAIIKSVSKLSNESMNIGMVHNFKLLRGILETPEGENGL 778  Desulfot...
WP_001328324       992 LSISNNTPIGELTNATPNGRLAWMPLSDGISPTQGADKHGPTAIIKSVSKMNVETMNIGMVHNFKFLKGLLDTPEGRHGL 1071 Escheric...
ZP_06114526        762 ITLLRTASIFGNGEMQFNYLDNNTLLEAQKHPEKYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHL 830  Clostridium hathewa...
ZP_08170365        781 VTLLRTACMYGNGEMQFNYLDNETMLDAQAHPEKHRDLVVRVAGYSAFFVELCKDVQDEIISRTMLEHF 849  Anaerococcus hydrog...
REF_jgi:Pcar_0937  740 ITLLRTASILGNGQMQFSYVDNEVLKQAQQSPEEYRDLMIRVAGYSAFFVELCKEVQDEIISRTTLSGF 808  Pelobacter carbinol...
WP_011189064       778 ITLIRTASMMGNGEMQFNYLDNDTLLDAQLHPEKYRDLVVRVAGYSAFFVELCKDVQDEIISRTMLTEI 846  Desulfotalea psychr...
WP_015850354       780 ITLLRTASALGNGEMQFNYLDNATLLDAQKHPEKYRDLVVRVAGYSAFFVELCKDVQDEIISRTMMNEI 848  Desulfovibrio salex...
WP_012624983       780 ITLIRSASILGNGEMQFNYLDNKTMLEAQQNPKDYRDLVVRVAGYSAFFVELCKDVQDEIISRTVLRHF 848  Desulfovibrio desul...
WP_012064911       777 VTLLRTASMLGVGEMQFNYLDNETLIKAQKNPEQYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTKI 845  Alkaliphilus metall...
WP_013251182       779 VTLLRTASMFGNGEMQFNYLDNKTLIDAQEHPERHRDLVVRVAGYSAFFNELCKDVQDEIISRTMLEKF 847  Olsenella uli
WP_011879563       779 ITLLRTASILGNGQMQFSYVDNEVLKKAQLEPDKYRDLIIRVAGYSAYFVELCKEVQDEIISRTVLEHF 847  Desulfotomaculum re...
WP_001328324      1072 ITLLRTASILGNGQMQFSYVDNEVLKKAQQEPEKYRDLIVRVAGYSAYFVELCKEVQDEIISRTVIEKF 1140 Escherichia coli
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