Conserved Protein Domain Family
myo_inos_iolD
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TIGR04377: myo_inos_iolD 
3,5/4-trihydroxycyclohexa-1,2-dione hydrolase
Members of this protein family, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (iolD), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. IolD hydrolyzes the cyclic molecule 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione to yield 5-deoxy-D-glucuronic acid. TPP is a cofactor. [Energy metabolism, Sugars]
Links
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Statistics
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PSSM-Id: 275170
Aligned: 34 rows
Threshold Bit Score: 912.745
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ZP_05404363    6 RL-TVAQALVKFLNNQYVEFDGKEVPMFEGIFGIFGHGNVIGIGQALE----E----D----PG----HL--IMRMGRNE 66  Mitsuokella mul...
ZP_06575145    7 RL-TTAQALVRFLSAQYTERDGVRRRLIAGTWGIFGHGNVAGIGQALV----E----Y----AD----VM--PYHQGRNE 67  Streptomyces gh...
WP_013919775   5 RL-TMAQALLRFLDAQYVSRDGRETKFVRGVMGIFGHGNVTGLGEALE----R----S----SG----SL--TFIQGKNE 65  Paenibacillus m...
WP_013406869   2 KL-TVAQALIRFLDQQYVERDGVEHKFFAGCFGIFGHGNVGGIGQALF----E----N----P-----EF--RYYQARNE 61  Leadbetterella ...
WP_011683250   4 RLvTVAQGLVSFLKNQYVERDGKEHRFFAGMLGIFGHGNIAGIGQALQ----Q----N----PD-----F--PYIPVRNE 64  Candidatus Soli...
WP_011720635   6 RL-TVAQALIRFLRAQYSERDGSRQRLIAGCFGIFGHGNVAGIGEALL----EeeiaN----PG----LF--PYYQARNE 70  Acidothermus ce...
WP_013864794   6 HL-TVAQATIKFLSRQYSESDGVERKFFEGCFGIFGHGNVAGLGQALL----Q----AeieePG----TL--PYVLGRNE 70  Microlunatus ph...
WP_013015943   5 RL-TTGQALVRFLANQWSERDGQTHRLFAGCFGIFGHGNVAGFGQALL----Q----D----GK----DLelPYYLARNE 67  Stackebrandtia ...
WP_012892055   2 RL-TVAQALVRFLAQQWTERDGAEQRLIAGCLGIFGHGNVAGIGQALA----E----Q----GAgthaAL--PYYLARNE 66  Streptosporangi...
WP_015793083  17 RL-TVAQALVRFLAVQHTERDGTEHRLIEGVFGIFGHGNVAGLGEALLglelQ----D----PA----LL--PYRQARNE 81  Catenulispora a...

ZP_05404363   67 QGMAHAAMGFAKQKRRKQMYACTSSVGPGAANMVTAAATATANCIPVLFLPGDTYADRQPDPVLQQMEQTVSLTTTTNDA 146 Mitsuokella mul...
ZP_06575145   68 QSMVHAAVGHARQLNRLSAQAVTTSIGPGATNLVTGAALATINRLPVLLLPGDYFASRVADPLLQQLEHPVAADVSVNDT 147 Streptomyces gh...
WP_013919775  66 QGMVHAAAAFAKQRNRMEIFACTSSIGPGALNMVTAAATATVNRIPVLLLPGDNFATRQPDPVLQQLEVAGDYTVSANDP 145 Paenibacillus m...
WP_013406869  62 QAMVHTAVAYSKMKNRLETFACTSSIGPGATNMVTGAALATINRIPVLLLPGDIFATRHIGPVLQQLEDPSNADASVNDT 141 Leadbetterella ...
WP_011683250  65 QSGVHLAAAYAKASNRLRTFACTSSIGPGATNMITGAALATINRLPVLLLPGDIFARRNVAPVLQQLESFATQDTGVNDC 144 Candidatus Soli...
WP_011720635  71 QAMVHIAAEYARMTNRLSTLACTTSIGPGATNLVTGAALATINRLPVLLLPGDIFATRVADPVLQQLETRWGFDVSVNDT 150 Acidothermus ce...
WP_013864794  71 QAMVHSAVAFARMRNRLQAYAVSSSVGPGATNMVTGAALATINRLPVLLLPADTFADRSASPLLQELELPTAGDVTVNDA 150 Microlunatus ph...
WP_013015943  68 QGMVHSAVAFARLRDRMSTFACTASIGPGSTNMVTGAALATINRLPVLLLPSDYFANRFPDPVLQQLEDPHSRDTSVNDA 147 Stackebrandtia ...
WP_012892055  67 QAMVHTAVGYARTRDRLTTFACTTSIGPGATNLVTGAALATINRIPVLLLPGDVFATRAASPVLQELEDPRSYDVTVNDT 146 Streptosporangi...
WP_015793083  82 QAMVHTAAAFARMRDRLSTYACTTSVGPGATNLVTGAALATVNRLPVLLLPGDVFATRPANPVLQELEDPRSLDISVNDT 161 Catenulispora a...

ZP_05404363  147 FRAVCKYWDRVTRPEVLMTACINAMRVLTDPAETGAVCIALPQDVEGEAWDYPDYFFQKRVHHIDRIKPSERAIEEAVKA 226 Mitsuokella mul...
ZP_06575145  148 LRPVSRYFDRVTRPEALIPSALNAMRVLADPAETGAVTLALPQDVQAEAYDWPEEFFAERVWHVRRPAPDPVELAAAVEA 227 Streptomyces gh...
WP_013919775 146 FKPVSKYWDRIERPEQLMPALLQAMRVLTDPAETGAVTLALPQDVQAEAYDYPLSFFDKRVHYIDRRPPAPEALGRAAEL 225 Paenibacillus m...
WP_013406869 142 FKPVSRFWDRVNRPEQLISSLLQAMRVLTSPAETGAVTICLPQDVQAEAYDYPEEFFKKRVWYMGRPLPDAQLLQRAAQI 221 Leadbetterella ...
WP_011683250 145 FKPVSRYWDRIYRPEQLLTALPEVMRVLTSPSDCGAVTLALPQDVQAEAYEYPEEFFRKRVWLIRRGQPDEVSFQRAVEA 224 Candidatus Soli...
WP_011720635 151 LRPVSRYFDRIWRPEQLPRSLLAAMQVLTDPAETGAVTLALPQDVQAQAYDWPVELFAERVWPIRRTPPDPAALRRAVEA 230 Acidothermus ce...
WP_013864794 151 FRPVSKYFDRVWRPEQLPAALLSAMRVLTDPVETGAVTVCFPQDVQAQAYDWPVELFAKRVWHVSRPLPESAIIGRAAEI 230 Microlunatus ph...
WP_013015943 148 FRPVSRYWDRIQRPEQLMSAALTAARVLTDPAETGAVTLCLPQDVQAEAYDWPQEFFVPRVWPVARPVPEPAALARAVEC 227 Stackebrandtia ...
WP_012892055 147 LRPVSRFFDRINRPEQLPSALLAAMRVLTDPAETGAVTLALPQDVQAEAYDWPEELFRRRVWHVARPVPEPAALARAQDL 226 Streptosporangi...
WP_015793083 162 LRPVSRYFDRVNRPEQLPAALMAAMRVLTDPAETGAVTLALPQDVQAEAWDWPEELFQHRVWHVPRPRADLAAIERAAAA 241 Catenulispora a...

ZP_05404363  227 IAKAERPLMIFGGGVKYSEAEAVFQKFAEKYGIPFGETQAGKGTITWEHELNMGGVGETGGLAANTLAKDADVVIGVGTR 306 Mitsuokella mul...
ZP_06575145  228 VRAARRPLIVAGGGVHHSEAEQALKAFVDATGIPVASTQAGKGSLRHDHPADLGGIGHTGTAVSDALARTADLVIGVGTR 307 Streptomyces gh...
WP_013919775 226 VQSARRPLIVAGGGVLYAEAAEELKALAEAFGIPVAETQAGKGALPWDHPLNAGAIGVTGSLAANRLAQEADLVIGVGTR 305 Paenibacillus m...
WP_013406869 222 IKEAKKPMIIAGGGVIYSEACSTLAEFSKNTGIAVAETFAGKGSLNFDHPLNLGAAGATGTEGANAYAAEADVVIGVGTR 301 Leadbetterella ...
WP_011683250 225 IRGARKPLIVAGGGVLMSEASEALARFASQTGIAVAETQAGKGSLAYDHAQCMGAIGATGTLAANRLAHDADLVIGIGTR 304 Candidatus Soli...
WP_011720635 231 VTASSRPLIVAGGGVIYSDATDALRAFVDATGIPVAVTQAGKPAIRYDHPLCLGAIGSTGTPAANAMASTADLVLGIGTR 310 Acidothermus ce...
WP_013864794 231 IRGAGKPLVVAGGGVHYSGATEALASFVEATGIPVGQTQAGKGTLAYDHPQCLGAIGSTGTTASNAIAHEADVVIGIGTR 310 Microlunatus ph...
WP_013015943 228 LTAARRPLIVAGGGVKYSLATDALRAFAAATGTPVAETHAGKGSVPWTQPSAVGGIGATGSAAANMLAAEADVVLGVGTR 307 Stackebrandtia ...
WP_012892055 227 LRRSRRPLIVAGGGVKHSQASHQLAAFAARHRIPVTETQAGKGAVPYDHPYAAGAIGHTGSAAANTLAREADLVIGIGTR 306 Streptosporangi...
WP_015793083 242 IKNSRRPLIVAGGGVTYSQATDTLRTFAHAAGIPVAETQAGKGALDESDPLSLGAIGATGTQAANLIAARADLVIGVGTR 321 Catenulispora a...

ZP_05404363  307 YTDFTTSSKWIFqNPNVQYVNINVSRFHAYKLDGIQVVGDAGAALEMLDEALGktGYHVSDAYA-ADIKAAKAAYTKEVE 385 Mitsuokella mul...
ZP_06575145  308 YTDFTTASGTLFqNPDVRFLNLNVTGFDAHKLAARTLVCDARTGLEQLTGALA--GHRVDAAYV-SEYRAGKERWEEVVE 384 Streptomyces gh...
WP_013919775 306 YSDFTTASKSAFrHPGVRFLNLNVSAFDGAKLSGTPLLADAREGLRLLREALQ--ESGYASGYApGEIAARKAEWDAEVN 383 Paenibacillus m...
WP_013406869 302 YSDFTMASHTAFqNPDVKFININIAEFDAYKQSALPLTGDAKTTLEALGRLLG--GYKTSKEYQ-EQAAAYNVSWDQKVA 378 Leadbetterella ...
WP_011683250 305 YSDFTSASMTAFqNPAVRFVNINTAEFDAYKVSAIPVVADARVTLEQLATALA--DYRVPAEYA-AEACGLKAKWEAETE 381 Candidatus Soli...
WP_011720635 311 FGDFTTASSTIFgAPDVRFVHLNITPSDAAKLAALPVVADARAGLDALREALA--GWRVPEEYS-AEARRQADAWRATVF 387 Acidothermus ce...
WP_013864794 311 YEDFTTASRTAFaNPDVKFVNVNVAPIDAVKHAGLAVQADAREALGALTGLLD--GYAVDDSYR-ARYTELDAEWDATVT 387 Microlunatus ph...
WP_013015943 308 YSDFTTASHSLFaDPRVRFVNLNVAAMDTVKLGGVSIVADARAGLEALSTAVG--TWKADPDWT-DRARRLAGDWRRATD 384 Stackebrandtia ...
WP_012892055 307 YSDFTTASRTLFa--GAAFLNINITAFDAAKHSGQMLVADARQALDALEP--G--DWNADPAWS-ARATELTRDWQAEIE 379 Streptosporangi...
WP_015793083 322 FSDFTTASHTAFaDPDVRFVTVNIAAFDAAKHAGVSVVADARSALEDLTAALD--GWRTEAAFH-AEIADVRARWATTVQ 398 Catenulispora a...

ZP_05404363  386 RVFHIQFGdnfvpevnddfdykaaekaykeavgETLPQTRVLGLLEEHMDPNGIIVGASGSLPGDLQRVWRP-KTVGSYH 464 Mitsuokella mul...
ZP_06575145  385 AAYRAEDDs------------------------AAPTQTQVLGALDAVVGDEDVVINAAGSLPGDLHKLWRA-RSPRQYH 439 Streptomyces gh...
WP_013919775 384 RLYTAEHEa-------------------------gFAQTRALGVINAAVGPEAVIVCAAGSLPGDLHRLWRA-AGPKTYH 437 Paenibacillus m...
WP_013406869 379 EAYAVVAE-------------------------DSMSQAEVIGAVNSFAGPKDVMVCAAGSMPGDLHKLWRC-TDPKNFH 432 Leadbetterella ...
WP_011683250 382 RLFHLNNA-------------------------GKPAQSEVIGAMWEASGPRDVLLSAAGSHPGDLHKLWRT-RTPNGYH 435 Candidatus Soli...
WP_011720635 388 DVYRQRSs-------------------------GLPRQSEVIGAVGEAAGETGTVICAAGSLPGDLHKLWRA-RDPRSYH 441 Acidothermus ce...
WP_013864794 388 DAYAQEEPa-----------------------pGLLTQNSVIGLVNELSDPRDVVVCAAGSMPGDLHKLWRT-RDPKGYH 443 Microlunatus ph...
WP_013015943 385 AAYHLDHg-------------------------PLPAQTAVLGALNDAVGHRDVVINAAGSMPGDLHKLWRA-SDPKQYH 438 Stackebrandtia ...
WP_012892055 380 RAYGGTE----------------------------LTQPVMLGIVNQAA-EGGVVVNAAGSMPGDLHKLWRA-TDPGQYH 429 Streptosporangi...
WP_015793083 399 GAYR--FAn-----------------------vPLPSQIEVIAAVNDAAEPGDVVVCAAGSMPGDLHRLWRTgGDPKSYH 453 Catenulispora a...

ZP_05404363  465 VEYGFSCMGYEVNAALGVKLAEPEREVYALVGDYAYMMLHSELPTSIAEGKKINVIVFDNMQGGCINNLEIGHGQGSYGT 544 Mitsuokella mul...
ZP_06575145  440 LEYGYSCMGYEIPAALGVQQAAPGTPVWALVGDGTYLMMPTELVTAVQERLPVKMVLIQNHGYASIGGLSEETGGERFGT 519 Streptomyces gh...
WP_013919775 438 MEYGFSCMGYEVSGAFGAALADPRRDVYALVGDGSYLMLHSELLTSLQEGRKITVLLFDNHGFQCIHNLQREHGSDGFGN 517 Paenibacillus m...
WP_013406869 433 MEYGYSTMGYEIAGGLGVKMADPSREVYVMVGDGSYLMLSSEIVTAVQEGVKLTIVLINNHGYASIGGLSKSLGSEGFGT 512 Leadbetterella ...
WP_011683250 436 MEYGYSCMSYEIPGAMGAKLADPTREVYVFLGDGTYLMMPTEIVTSVQEGIKIIIVLVDNHGFASIGGLSRSLGQGGFGT 515 Candidatus Soli...
WP_011720635 442 VEYGYSCMGFEIPAGIGAKLACPDREIFVMVGDGSYLMLPGELVTAVQEQIKIIVVLLDNHGFASIGSLSESVGGQRFGT 521 Acidothermus ce...
WP_013864794 444 VEYGYSCMGYEVAGGLGVRMACPDRDVFVMVGDGSYLMMATELATAVQEGIKIITVLVQNHGFASIGSLSESLGSQRFGT 523 Microlunatus ph...
WP_013015943 439 VEYGYSCMGYEIAAGVGAKLADPTREVYVLVGDGSYLMMASELVTAVSERLKLIVVLVDNGGFASIGGLSQSVGSQRFGT 518 Stackebrandtia ...
WP_012892055 430 VEYGYSCMGYEIAGGLGVKLAAPEREVFVLVGDGSYLMMAQEIATAVQEGVKLVVVLVDNHGFASIGNLSESVGAQRLGT 509 Streptosporangi...
WP_015793083 454 VEYGFSCMGYEIAGGLGVKLAAPEREVYVLVGDGSYLMLAQEIVTAVAERVKLIVVLVDNAGYASIGALSESLGAQRFGT 533 Catenulispora a...

ZP_05404363  545 EFrfrnEK-TGQLDGAYVPVDFAMNAASYGCKSYTAHTEEELIAAIEDAKKQKVSTLIDCKVMPKTMVHGYGD-WWRVGI 622 Mitsuokella mul...
ZP_06575145  520 AYrh-rAE-DGTFTGAPLPVDLAANAASLGMDVLRAKTVRELREALAEARASDRPTCVYVETDPAPTAPPAEA-WWDVPV 596 Streptomyces gh...
WP_013919775 518 EFrrrsQE-TSRLTGAYLPIDFAAHARALGAKAYKASTPEELEEALRLAKEESITTLIEIPVVPGTNTGGYES-WWNVGV 595 Paenibacillus m...
WP_013406869 513 QYry-rGE-K-HFDGDALPYDLATNAESLGATVLRTSNESSFKAALEQAKKNANTTVIYIETPPERKMAGYGHaWWEVPV 589 Leadbetterella ...
WP_011683250 516 SYklrgKE-SGQLDGETLTVDYVANARSLGAHALKAGTLAELKLALEKAKTLDRTTVIVVETDPAVGVPGYES-WWDVAV 593 Candidatus Soli...
WP_011720635 522 NYry-rSRlTGRLDGDILPIDFTANAASLGMVAWRAETVDELRGLLEKAKAETRPVLICIETDPTPSAPDSEA-WWDVPV 599 Acidothermus ce...
WP_013864794 524 AYrrrdAE-TGRLDGAKLPIDLAANAASFGLEVLKATTKAEFAEAIKTAKAAEHPIVIYVETDPLIDAPSSQS-WWDVPV 601 Microlunatus ph...
WP_013015943 519 SYrhrdAA-TGELDGDPLPVDLGANAASLGATLIRADSIGEFALALSRAKHNDGVTVVHIRTDPLAPSAPSTA-WWDVPV 596 Stackebrandtia ...
WP_012892055 510 SYrm-rGP-SGELDGAFLPVDLAANAASLGADVLTANDPGTLRTALAKAMASTRTTVVHVETVPGPS-PETTA-WWDVPV 585 Streptosporangi...
WP_015793083 534 AYry-rGA-SGRLNGGPLPVDLAANAASLGANVERATDIEEFVAALDRAKKADRITVVHVATDPMAGAPDGGA-WWDVPV 610 Catenulispora a...

ZP_05404363  623 AQVSKSKKIHDCYENLMKPHYDAAR 647 Mitsuokella multacida DSM 20544
ZP_06575145  597 AEVASREAAVRARERYDSQVAGRRR 621 Streptomyces ghanaensis ATCC 14672
WP_013919775 596 PEVSVSGKVLEAHRGMKSRIEAvtv 620 Paenibacillus mucilaginosus
WP_013406869 590 SEVSNTASIQEAYEKLTLNKKRQRW 614 Leadbetterella byssophila
WP_011683250 594 AEVSESESVRHARARYDEARKKERY 618 Candidatus Solibacter usitatus
WP_011720635 600 AEVSDLESTRAAYAEYQAAKARQRP 624 Acidothermus cellulolyticus
WP_013864794 602 SETSTLTSTQQASEFYRGKKAEQRP 626 Microlunatus phosphovorus
WP_013015943 597 AEVAELDTTRKARTEYEAAVKRQRH 621 Stackebrandtia nassauensis
WP_012892055 586 AEVSSLPEVRTVRRHYEDHKRDQRP 610 Streptosporangium roseum
WP_015793083 611 AQVSDLESTRAARTGYEEAKKAQRP 635 Catenulispora acidiphila
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