Conserved Protein Domain Family
HEXXH_Rv0185
?
TIGR04338: HEXXH_Rv0185 
putative metallohydrolase, TIGR04338 family
This protein family is restricted to the Actinomycetales, including Mycobacterium, Rhodococcus, Nocardia, Gordonii, and others. The invariant motif HEXXH, at the core of the best conserved region in the protein, suggests metallohydrolase activity, as does local sequence similarity in this region to other metallohydrolases.
Links
?
Statistics
?
PSSM-Id: 275137
Aligned: 16 rows
Threshold Bit Score: 197.578
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EIM44311       5 RDTQRTAVYDAEALVRTMFDRa--------dE--RGLRVVDVLGSQVTLPVERKFASIDSVQDYVDRVLALNWVRSTWTR 74  Rhodococcus opa...
ZP_09791158    8 RDSQRGLVYSAEDLLRSALDA----------R--SSIGVIEIAGTRVTLPPEARFASIESMQRYVDAVLSRPSVRERFGC 75  Gordonia otitid...
ZP_09789829    4 RDTGRERFYEAERLIRGLFDR----------A--GDHRTVQLAGTELTLPVEAQFGSIDSVREYVGRVLTMPSVTARFDA 71  Gordonia otitid...
ZP_08765157    4 RDTGRARYYDAERLVFRLFDT----------A--SSSRTVQLAGTELTLPAEARFASIDAVRDYVGLVLELPSVRSRFPR 71  Gordonia alkani...
ZP_09213712    6 PDRQRSAVYAAERMVLGLFDN----------V--GSTRAATIGGTNLTLPAEAKFASLDSIRRYVDGVLSLPAVIDRFPR 73  Gordonia araii ...
ZP_09275204    4 TDTGRGAFYAAEALVHNLFERngasgatgsvT--GASGATTVAGTTLTLPPEAKFASVESIARYVDEVIAMRSVQDTFPR 81  Gordonia effusa...
WP_014361140   4 RDTGRSRLYEAERLVHRMFDR----------A--GSARTVQIAGTELTLPIEALFSSVESVRSYVERVLAMNSVRQRFPR 71  Gordonia polyis...
WP_012833006   4 RDSGRTAYYRAEQLVFTMFER----------A--PSTRAVQLAGTELTLPVEARFASVQSVREYVARVQAMATVRERFRR 71  Gordonia bronch...
WP_014353620   4 RDSQRAKVYDAEQLVRGAFDR----------AdeFGHRTVEVFGSQITLPVERRFASVDSVQDYCDRVLALNWVASQWAR 73  Nocardia cyriac...
WP_012814008  14 RDGQRAKVYEAEHLVHRIFDR----------S--AEYPVVQIAGSQLVLPPERRFGSVPAVQVYVRRVLDLGWVRATWPR 81  Nakamurella mul...

EIM44311      75 AATPVHVRARSGNKAAHYESDCA---------TIAVPEHRngnaWAFRELVVLHEVAHHLD---PSDPdyptvaPHGPEY 142 Rhodococcus opa...
ZP_09791158   76 VAP-VRVRARRGTNAAHYEPNNN---------TIAVPVGDdstpF-RRESVVVHELAHHLT---EYGPht---aSHGPEF 138 Gordonia otitid...
ZP_09789829   72 ARRPVTVRSRRGNRSAHYAVDSSgg------rEIAIPDGRdg-rWALREAVVLHEIAHHLDe--SDGP------AHGRGF 136 Gordonia otitid...
ZP_08765157   72 AAEPVSVRERRGQSSAHYARSTTisgdkllsaEIAIPSSAeg-rWALRELVVLHELAHHLDd--SKGP------GHGRGF 142 Gordonia alkani...
ZP_09213712   74 ATVPVRARARRGVKAATYEAGEGg-------gVIAIPESAsg-rWALRELVVLHELAHHLDd--SGEA------AHGSPF 137 Gordonia araii ...
ZP_09275204   82 AAQPLTVRARKGFRAAEYRRSADaae----pgEIAIPHRGag-sWALRELVVLHEIAHHLDd--TGGA------PHDAGF 148 Gordonia effusa...
WP_014361140  72 ASEPVTVRARGGHRAAEYRRDIG---------EIAIPDSReg-rWALRELVILHEMAHHLDd--GTGP------AHGRGF 133 Gordonia polyis...
WP_012833006  72 AAVPVTVRPRRGNRKAHYAPAKA---------EIAIPDAAeg-rWALRELVVLHELAHHLDe--SEGP------AHGPGF 133 Gordonia bronch...
WP_014353620  74 ASTPVRVRARAGTTAAHYEADGA---------VLAVPLHTsgtaWALRELVVLHELTHHLEprpGERA------PHGPEF 138 Nocardia cyriac...
WP_012814008  82 ATVPVRVRERAGSTQAHYERAGA---------VMAVPGYRtgsgWALRELVILHELAHHLAd--QVEP------AHGGPF 144 Nakamurella mul...

EIM44311     143 VDRYLTLVGEIIGPEAAFVLRTMLLAGGV 171 Rhodococcus opacus M213
ZP_09791158  139 VCVLLWLIGDVMGAEAAFVLRTFMFQHGV 167 Gordonia otitidis NBRC 100426
ZP_09789829  137 TQTLTELVGLVMGPEAEFVYRVVLADSGV 165 Gordonia otitidis NBRC 100426
ZP_08765157  143 VLTFIELVGLVLGPEAAFVFRVVLADSGI 171 Gordonia alkanivorans NBRC 16433
ZP_09213712  138 RGVLVDLVEAALGPEAAFAYRVIFGESGL 166 Gordonia araii NBRC 100433
ZP_09275204  149 AETLITLVGLVLGPEASFVYRVILTDSGA 177 Gordonia effusa NBRC 100432
WP_014361140 134 VVTLTDLVGAVLGPEAAFVYRVVLTDSGV 162 Gordonia polyisoprenivorans
WP_012833006 134 IETITTLVGLVLGPEAGFVYRVVLADSGV 162 Gordonia bronchialis
WP_014353620 139 CSRYVELVDGVIGPEAALLLRGTMIGCGV 167 Nocardia cyriacigeorgica
WP_012814008 145 VDRLLTLVDGVIGAEAALLMRITMLDAGV 173 Nakamurella multipartita
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap