Conserved Protein Domain Family
Rama_corrin_act

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TIGR04270: Rama_corrin_act 
methylamine methyltransferase corrinoid protein reductive activase
Members of this family occur as paralogs in species capable of generating methane from mono-, di-, and tri-methylamine. Members include RamA (Reductive Activation of Methyltransfer, Amines) from Methanosarcina barkeri MS (DSM 800). Member proteins have two C-terminal motifs with four Cys each, likely to bind one 4Fe-4S cluster per motif.
Statistics
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PSSM-Id: 211993
Aligned: 5 rows
Threshold Bit Score: 891.422
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012035437   4 LAIALDLGTSGFRAQALNLESRETLSTVITSCHPLPGDNVIDHISFALDAGIEVARKLIVEAVNRLIAALGVPLDEVSVF 83  Methanocella ar...
WP_011405806   5 YAIAMDIGTSGVRAQAINVEDNSTISTTVTLRHPIPGANVMDHLHFAVNVGREQAHQLIMEAVNKVVDQLEVDKSKITRF 84  Methanosphaera ...
WP_011033386   2 YGIALDLGTSGFRAQLIDLETDETLKTVITMGHPLPGGNVMDHLDFAITTGEDVAHGVIIETIRRMFLKFDADLSKVERL 81  Methanosarcina ...
WP_011032890   3 YGVAVDLGTSGYRAQKIDMDTREIKRTVITLRNPLPGANVMDHMDFAIRYGQDLAHGLSVNAVKTLLQTLDVPSEELDRI 82  Methanosarcina ...
WP_011308490   3 QAINIDIGTSGIRAQLLNLMDSSVLRTAILSRNPLPGANVVDHMDFAINYGQGIAHEILISAVNSLIKNL--KPENLKRV 80  Methanosarcina ...
WP_012035437  84 GVCGNPAQLSLFQGMEIRDLAYAGKRKLDSLGVNVPRREAAVLKAWQFpGLLLPPDCDILIPPAVRHEVGADALALIIKT 163 Methanocella ar...
WP_011405806  85 AVCGNPIQLSLFQNIEIRDLAFWGTNAVERMKITPPKRNAQIIKPGDV-DLDINPDADVYIPPAIKHEIGADALAMLVKS 163 Methanosphaera ...
WP_011033386  82 AVCGNPIQLSLFQNIEIRDLAYAGENKQKMLGVQNVTRDSRVFPASDIfGDDFFRGCEIIVPPAIKHEIGADALAMMLET 161 Methanosarcina ...
WP_011032890  83 SICGNPIQLSIFQGITIEDLAYAGERKKKKYNIQEQTRNARIIPSSEIsGLEEF-NCEVVVPPAIKHEVGADALALITKS 161 Methanosarcina ...
WP_011308490  81 AVCGNPIQLSLFEGIEIRDLAFAGKNALEKINVKLPERNGHMVSGNEI-GLCA--DVDVVIPPSVKHEIGADALAMMVKS 157 Methanosarcina ...
WP_012035437 164 GMLERDETSLAIDYGTNAEMALFHNGVVYTGSTAAGPALEGQQITCGTIAIPGAICDLEPEettdVPFYRLMMLDAGMSP 243 Methanocella ar...
WP_011405806 164 GVVDKEGIYLVSDFGTNAEIALVIDGEIFSCSAAAGPAMEGQAIECGMLASPGAICDVTAE----GDQWRNMVLNSDLKV 239 Methanosphaera ...
WP_011033386 162 DFLIQTEPALVTDYGTNAEMALKVGDRIITASAAAGPAIEGQGISSGMLASPGAICDVKPE----GEYWKVMVLDNEMEK 237 Methanosarcina ...
WP_011032890 162 GMLESDEISIATDYGTNAEMALKVKDIIYTGSAAAGPALEGQQIKHGTLASPFAISDFEFE----NGALRNYVLNEEMKP 237 Methanosarcina ...
WP_011308490 158 GFLDTPEACMVTDYGTNAEMALKVGNRIYTGSAAAGPVIEGQQISKGMLATPGAIADLKLS----GG-WQSLVLDEKLRL 232 Methanosarcina ...
WP_012035437 244 VPGPVVDFRESRFVGSGV-PrPA-GITGTGTVAAIYEGIECRLICLPHITTTDRRLHFGEDVYLAEADLIEAGKAMGAIR 321 Methanocella ar...
WP_011405806 240 DACNLMDVTTGEIIEQQNpQtQArGITGTGVISAYSLGTEQGIISIPDIKTDDNKINLQDDVYLSEKDLTEIGKALGAFR 319 Methanosphaera ...
WP_011033386 238 QDAYLINPVTGEMKET-N-GyEAaGITGTGVISAFALALRSGLVEKPP-KLPNGKLILGPGIEITEKDVEEAGKAIGAIR 314 Methanosarcina ...
WP_011032890 238 DPGDLVDPKTGEILEEG--KiKAkGITGTGVIALIEKAIGYGLVELPKVKTPDGFIHLQNNISFSERDLKEAGKAIGAIR 315 Methanosarcina ...
WP_011308490 233 VEGPRIDLRNRTFKTIGY---PAkGITGTGVIALMYAGLVTGIIKPPHI--EGDIIRLGKEITFTEKDVVEAGKAFGALR 307 Methanosarcina ...
WP_012035437 322 AGYIALCKRAGIAIQDIDTVYMSGSAGTYMDALKAQKLGLIPPRVSKVCHVGNTSLAMARDLVSDPAKLGEMSELARKLK 401 Methanocella ar...
WP_011405806 320 AAHITLCVEAGIELDDIDAVYMAGASGFYVDPMKSLTVGQIPACSWDIYQIGNTSLSMARDIVENPDLLSELQEVADGMR 399 Methanosphaera ...
WP_011033386 315 AAHMTLIVESGIKYEDLEYAYMSGASGAYVDAEDARRLGAVPGYAKKIVQFGNTSLALARELVLDKSRLDDVIKIAKKIT 394 Methanosarcina ...
WP_011032890 316 AGHITLCAAAGIEMTDIDVAYMAGAAGTYMDAEKAQKIGLIPYSTGKIAQLGNTSLAVARETLLSEERLWELQDIASQII 395 Methanosarcina ...
WP_011308490 308 AGHLTLMHEAGIAYEDLETMYMCGASGTYVDPIKARFTGIVPATPKRIVQCGNTSLELAKDLALNPDYLSYLNEMKESVL 387 Methanosarcina ...
WP_012035437 402 RYHCMFALSAVFKKAYVLELSYWTEGMPAHLHRSLLKRYGLPDLPPVAGTPEVLHLVKKDIEDTGIMGLTTLHDFGSSAD 481 Methanocella ar...
WP_011405806 400 GNHITLATSEIFEKIYGLELAVCEQNMPLWKYDEWLESYGYGNLPEVEDDPEIHRLFESDIPDIGVNGLSIIEEVGTKLE 479 Methanosphaera ...
WP_011033386 395 ADHLMMATSNTFNNFYLCELSYWTMGMPLEMYNQMLELYGLPKLPETLEHVSIEKRVSKDIEQVGVGGLALLKEIGIILE 474 Methanosarcina ...
WP_011032890 396 GTHIMFATVPEFRDAYVLELAYWEEGMPFKMFKKYLKKKGLPSLDDPISNPVVDKRVERDIPVLGEEGLYVLERVGTYMT 475 Methanosarcina ...
WP_011308490 388 SNHIMFASSPTFASIYVQEIALWNEGMPLEKYNANLERSGIQPIPQKFQESLIERKSNEDIHELGK-CLKIMESKLDFIA 466 Methanosarcina ...
WP_012035437 482 AQFEGCTACWQCVSGCPGKALSAlKSEPPVvaI---DPSRCKGMACRRCERICPERVFKVRQFFS 543 Methanocella arvoryzae
WP_011405806 480 SKVEGCISCQACANECPESALKI-EDGVAT--I---RSDYCNGSACLRCELVCPEKVFLYEKMFY 538 Methanosphaera stadtmanae
WP_011033386 475 VPVEKCIYCQKCMEECPENALEItETDGIR--TakyDSQKCLGTSCRRCVSVCPENAIDITKLRI 537 Methanosarcina mazei
WP_011032890 476 MVVSDCPECRKCIKVCPNDAISIdEENRVM--I---STDLCEGAHCQKCIRACPPDKFDWKNLEV 535 Methanosarcina mazei
WP_011308490 467 TI--KCSGCDTCLKECPGEALSR-ECESFR--I---NTARCLGTTCRRCEEKCPEKRFSISNFKL 523 Methanosarcina barkeri
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