Conserved Protein Domain Family
FxSxx-COOH
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TIGR04268: FxSxx-COOH 
FXSXX-COOH protein
Members of this family are very short (~60 residue) polypeptides, among which the fifth and third to last residues are nearly always Phe and Ser, respectively. Because members occur in a conserved context with a putative peptide-modifying radical SAM/SPASM domain protein, we suggest that members of this family may be the modification target. The gene symbol fxsA reflects both the FXA motif and the proposed role as a ribosomal natural product.
Links
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Statistics
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PSSM-Id: 275092
Aligned: 42 rows
Threshold Bit Score: 25.9952
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_007382873 14 LDVTGLSMEALDelleELPGTALNAVLRRMVDEaVNPVGVPYAA-FDSSI 62  Streptomyces sviceus
WP_009306832 15 APKGLDRLTAI-----NTSAPGTLRSIARVTDV---PGRLDRSAeFNSTI 56  Streptomyces ipomoeae
WP_010056998 12 PAKTRATLAAT-----DVRSADAVTKINRVCGA-TTARSTRIST-FNSAL 54  Streptomyces filamentosus
WP_013003915 30 AHKRLAPLATV-----AAHEPRTQRSTGRVTDA--RDLRLARQG-FTSSI 71  Streptomyces scabiei
WP_014442475 16 AVINETPLREI-------RAEHASRVVRRIVDKeSLLKRLDVAA-FQSAH 57  Actinoplanes missouriensis
WP_018799151 28 ADLRHTPLGKIP----LSRARAVALPDTRIVDQ---PTRVDVAA-FGSSI 69  Salinispora arenicola
WP_010987118 18 THKKLAPLSAI-----NTHEAAALRSTGRVTDI-PGRRPTKPIT-FDSAL 60  Streptomyces avermitilis
WP_014137554 14 AAFERAALADLA----ALDVEDLTAQIERVLPA-AASRQVAVAA-FQSSI 57  Kitasatospora setae
WP_014157097 13 AKKSRVPLTEI-----DARSTDASRKLGRVFGI-STGRPLQTST-FSSAL 55  Streptomyces flavogriseus
WP_015576602 12 VAKRRVPLAKI-----EASSSAAARKMGRVLAT-SGGRPTEIST-FNSSL 54  Streptomyces sp. PAMC26508
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