Conserved Protein Domain Family
SasC_Mrp_aggreg
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TIGR04263: SasC_Mrp_aggreg 
SasC/Mrp/FmtB intercellular aggregation domain
This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.
Links
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Statistics
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PSSM-Id: 275089
Aligned: 18 rows
Threshold Bit Score: 348.16
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ZP_04060578   153 STTNTDPmVVNEQNTGqIINGTFTDNSQGATIPTKNLESAMNE--ANTVPGWHVNSNDQT-IIPLIWGPKSLPAYNPYIF 229  Staphylococcu...
EHM86483      221 YTPTTDP-NANNIGQN-APNEVLSFDDNNIRPSTNRSVPTVTV--VDNLPGYTLINGGKVgVFSHAMVRTSMFDSGDAKN 296  Staphylococcu...
ZP_09146875   204 NAANTDP-GTNNVG---SINEVFTFDNNGINPSPDKLRPAVTV--VSNLPGFTMINNGKVgVLSASLVRTSVFNQGDPKN 277  Staphylococcu...
ZP_08050967   241 TAASTDPlAANEHGVS-IINGDFSDTTLGAELPTATSPIASTIveLSKLKGWNAVDSSTNkVL-LIWAAKT-GIYESQLP 317  Streptococcus...
EGS41195      210 NNVSNDPlKANEVNPE-IQNGNFSQVSGGILPSRSKR---LTV--VTNVDNWHSYSTDPNpEYPMFYTPSA-VDYSSFMS 282  Staphylococcu...
EGS78205      205 SNLSTDPlKANEINPE-IQNGNFSQVSGGPLPTSSKR---LTV--VTNVDNWHSYSTDPNpEYPMFYTTTA-VNYPNFMS 277  Staphylococcu...
ZP_04817328   218 TVASTDPlSKNETDAS-IKNGNFRQVSGGNLPTRSNK---LTI--VRGVDHWHSLSKDPNpEYPILFTPAA-KDYANFMS 290  Staphylococcu...
ZP_09145374   157 PASNNDPlHFNETNTS-IENGHFDHVTGGTLPTTSQK---VTV--VTGVDHWTSLSTAPNpEFPIFNTLTA-KDYRPFMS 229  Staphylococcu...
WP_000468780  239 TVTSTDPlATNATNVA-IVNGNFNDTSQGAVLPTAKSDPITVKndISKLTGWKPVNSTTT-TVPLIWTANA-SQYGDAFP 315  Streptococcus...
KDP48234      160 VDNNQDQmSINETNSGqIINGTFTDTSNGAVIPTNQTVSEMNQ--AGKITGWHVKDNDQT-EIPLVWGPKALPPYNPYVF 236  Staphylococcu...

ZP_04060578   230 DKTnNKIGVVLSKYNGNFNQVPGiadpTVGSIYQDVDVTPGSEIQLHYisSSMNNIWGVNGARVYIYDANNPSTLLYKGT 309  Staphylococcu...
EHM86483      297 YQA-QGNVIALGRIKGNDTNDHG----DFNGIEKTLTVNPNSELIFEF--NTMTTKNYQGMTNLVIKNADNDAILGEKVV 369  Staphylococcu...
ZP_09146875   278 DQA-SDNVIALGRVLATNTSDTG----DFNGIEKIVSVHPNSEVVFQF--NTMASADGNGATILVLKNAADDSEIARATV 350  Staphylococcu...
ZP_08050967   318 GPK-TKIAAVLSAYNERGAGGTPn--tEYGPIYQDIDVVPGQEVIVSYrsQSIGQTTGINGAKLIVKDANTDTKIAEDKA 394  Streptococcus...
EGS41195      283 NNG-GPYGVVLARTNNGRDRSVNd--aKVAGIYQDIDVVPGSELNVNFisTSPVFSDGASGAKLKISNIEQDRILFDNRL 359  Staphylococcu...
EGS78205      278 NGN-APYGVILGRTTDGWNRNVId--sKVAGIYQDIDVVPGSELNVNFisTSPVFSDGAAGAKLKISNVEQNRVLFDSRL 354  Staphylococcu...
ZP_04817328   291 DNT-DPYGVVLARTTNGWDRSVLd--pRVAGIYQDIDVTPGSELVINFisTSPTFTDGVTGAKLKISNVEGTQTLFDKRL 367  Staphylococcu...
ZP_09145374   230 DAS-APYGVVLARTTDGNNRNVLd--pKVAGIYQDISVVPGSELVVRFtsASMTFKSSVTGAKLKISDTTGSQILFDSRL 306  Staphylococcu...
WP_000468780  316 GDRgSGIGAVLAVYPGRGAWS-GrqkpEFGPIYQDIDVVGGQEVKVTWrgTTVNINSGNNGAKLVVKNPETGAVLGQYAR 394  Streptococcus...
KDP48234      237 DKTnNKIAAVLSKYPNNLGGVAGd--kTVGPIYQDVDVTPGSEVQLYFigTSMGNTNGINGVKVSIYDSNNPTDLLYSGR 314  Staphylococcu...

ZP_04060578   310 PDilqnpiGNFVGVFQVPETVSRLRLRFESALNRSTDSTNGHRLLTGP-----NNFggGVLADVTINSGAYLtaTVNNTH 384  Staphylococcu...
EHM86483      370 AY------GPIWRLFKVPENVSHLKIQFSPKNDAITDVRGIYQLRDGY-----KYY--DFVDSIGLHSGSHL--YVERRI 434  Staphylococcu...
ZP_09146875   351 DG------GSTLRLATIPANVTDLKIQLLPDASVHGNFRRVTKNQDGY-----KYF--SLVDTIGVKSGSHA--YIKNIN 415  Staphylococcu...
ZP_08050967   395 DYrgy-plGEFSKIVNVPDGVTKLRLQFESINNRSHDEANTHRTPDGI-------YagASVSNVRVGSGAYVvpTVTETS 466  Streptococcus...
EGS41195      360 NGmgpyptGKLSAMVNIPSDMNRVRISFLPISNTGRISVQRSSKEHGFgd-nsSYYhgGSVSDVRINSGSYItsNVAQVE 438  Staphylococcu...
EGS78205      355 NGmgpyptGKLSAMVNIPNDINRVRISFLPVSSTGRVSVQRSSREHGFgd-nsSYYhgGSVSDVRINSGSYVvsKVTQRE 433  Staphylococcu...
ZP_04817328   368 DAmqnfptGWLKAMVNIPDNMNQVRISFLPISINNALTTRESNSGHGFgd-npNYNygGTVSRVTANTGAYVvsRINQVN 446  Staphylococcu...
ZP_09145374   307 NGmgnfptGKLTVLVNIPENLNRVRVMFLPISNKSNLTSGQTSSANGFgsapaNIYygGVVSNVSVNSGAYIetSVPQTS 386  Staphylococcu...
WP_000468780  395 GYagt-pmGEMSVLVNVPKGLTKLRLQFETALDKSTENHSGDNRFNKPsi-ssDENagGVVSNVRVASGSYLvsEVVNTT 472  Streptococcus...
KDP48234      315 PNtasksfGVFTGVFNVPNNVSRLRFMFETFEKRSYESANGGRILKGK-----NNFggSGLADVKVNSGAYLkaTTTQTK 389  Staphylococcu...

ZP_04060578   385 YFAQSGSINADRVYQEIEFRIENRGHSSSNKTEYTIVLPEDVTYVSTKNATG------------------KFNAATKELT 446  Staphylococcu...
EHM86483      435 MEPTATNNKEFTVTTSLKNNGNFGASFNTDDFVYKIQLPEGVEYVNNSLTKDfpsgnsgvdmndmndmnvTYDATNRVIT 514  Staphylococcu...
ZP_09146875   416 YNNTIKTDSDLAIDATISNDGNFGASLDNGALVYKVKLPDDVTYVDNSLVTStpignvan--tdvnpftvAYDRTANTVT 493  Staphylococcu...
ZP_08050967   467 FSKTAVSATAQKVTVRIQARLENKGEATSTSPVYSLAIPEGARLASYDRSKI------------------VPSTSGNQLS 528  Streptococcus...
EGS41195      439 YITQPNSPNDNFARATVNLSVENKGHNQSRDTYYEVILPANSKLISSSGGTG------------------NLDVNTNKLR 500  Staphylococcu...
EGS78205      434 YTTRPNSSNDTFARATINLSVENKGHNQSKDTYYEVILPQNSRLISTRGGSG------------------NYNNATNKLS 495  Staphylococcu...
ZP_04817328   447 YDAVASTPTSNVARATVSLTVENKGHTQSKETTYKVVLPPNSKFISATGANG------------------NYNANTNTLT 508  Staphylococcu...
ZP_09145374   387 YTVSANSATANAVRATVSFNLENKGHNFAKSVDYKVTLPANSKFISATGAQG------------------SYNQATNVLT 448  Staphylococcu...
WP_000468780  473 YESTATSATPTTVNTTVTVKVINKGFSTSTNNQYRVELPEGATLVGTTGTSS-------------------AQLNGTSLT 533  Streptococcus...
KDP48234      390 YTVTSPSTSTSLINATLEVSLENKGHSRSNKTQYKVVLPEGVQFISAQNARA------------------NYNSSNRLLT 451  Staphylococcu...

ZP_04060578   447 VKIDRLEAGASKN------------ISIGLSLPT-DRPIEKEFLGHLTYVTDGinmnrlsdskDFGRNngdhytrygvhn 513  Staphylococcu...
EHM86483      515 IKSTGGGSGNSPArlmpd---kildLKYKLRVNNvPTPRTVTFNDTLTYKTFS----------QDFIN------------ 569  Staphylococcu...
ZP_09146875   494 FSSNGLTAKNGAPntpmllplkeinLKFKVHINRiNTPKTVNLESNITYKTYT----------ELTMN------------ 551  Staphylococcu...
ZP_08050967   529 MRINSVRPKSSQD------------FWYELELPA-TKAETFVLNPTVTYQTNG----------NLISGtt---------- 575  Streptococcus...
EGS41195      501 MSISNLNPGERKD------------LSYTVEFKA-TIPKIVNLNGHVSYRTNA----------TFRGR------------ 545  Staphylococcu...
EGS78205      496 IRLDNLNPGDRRD------------ISYTVDFES-SSPKLINLNAHLLYKTNA----------TFRGN------------ 540  Staphylococcu...
ZP_04817328   509 LNISNIHGGNTKD------------ISYTVEFEA-MRPKLVDLNGQISYKTNA----------PFRGD------------ 553  Staphylococcu...
ZP_09145374   449 LSIGQVGIGQRRT------------ITYTTELQA-TEPKNVELNGNLTYQTDA----------PFRGT------------ 493  Staphylococcu...
WP_000468780  534 LGFNNLDPKREQT------------LTYTFSLPT-NKPIEKQLEGTVSYQTSG----------NLIDN------------ 578  Streptococcus...
KDP48234      452 LNVDRIEPGTIKN------------ITYTVSLPT-SEPIKKDFDATLVYVTDGinmnrrngsrDFGSNaddnyfryggyn 518  Staphylococcu...

ZP_04060578   514 efvsvdSAMRQGDIVLDKQTITVKMYKQHLRDKVTEI 550  Staphylococcus hominis SK119
EHM86483      570 ------SPAESHTVSTNPYTIDIIMNKDALQAEVDRR 600  Staphylococcus aureus subsp. aureus 21194
ZP_09146875   552 ------NANPPYTTATTSSPLSIIMNKDALQTQYDFI 582  Staphylococcus simiae CCM 7213
ZP_08050967   576 ----vaTTKKEGVITSPTQTVTVNMYKADLRAEEAKA 608  Streptococcus sp. M334
EGS41195      546 ------DTQRTGDNTVNLQTVTIQMNKTELQSKVNEV 576  Staphylococcus capitis VCU116
EGS78205      541 ------DGQRTGDNIVDLQSIALLMNKDVLETELNEI 571  Staphylococcus epidermidis VCU105
ZP_04817328   554 ------GSQKTGNNSVNTQTVTLKMNKTDLESKLTEV 584  Staphylococcus epidermidis M23864:W1
ZP_09145374   494 ------GIQKTGNNSVNTQTVQILMYQTDLQTKVNDV 524  Staphylococcus simiae CCM 7213
WP_000468780  579 ------GTKKTGSDTVAQQTVKINMYKADLQAEAAKV 609  Streptococcus mitis
KDP48234      519 eyvkteSNQRRGNVTVATQSVTVEMYKTDLQQKYNQI 555  Staphylococcus aureus subsp. aureus CO-98
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