Conserved Protein Domain Family
GG_sam_targ_CFB

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TIGR04149: GG_sam_targ_CFB 
natural product precursor, GG-Bacteroidales family
Sequences in this protein domain family include a leader peptide region, up to and including a Gly-Gly cleavage motif, and about 15 additional residues, usually Cys-rich, from a family of predicted ribosomal natural product precursors. Many of these are associated with peptide-modifying radical SAM enzymes. The core region, up through the diglycine motif, resembles and contains some overlapping hits with the bacteriocin precuror leader peptide region modeled by TIGR01847, but is longer with an extreme N-terminal region with consensus sequence MKKLKKLKL. [Cellular processes, Biosynthesis of natural products]
Statistics
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PSSM-Id: 275012
Aligned: 22 rows
Threshold Bit Score: 29.9316
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_06995580    1 MKKITKTNFQGLRQlfpvLEKEEMRHYIGGTFggyyytggWNGDGGYYGSSGS 53  Bacteroides sp. 1_1_14
ZP_05544082    1 MKQVRKLKLSQLSKn--eLEKKELKKLKGGGC--------CICGGGGGSANAS 43  Parabacteroides sp. D13
ZP_05543753    6 KQILGKLKLNKLSEn--eLEKREMRILKGGSD--------CPDGCSPNTSISN 48  Parabacteroides sp. D13
ZP_05285322    6 QQVLKSLKLNKLSEn--hLEKREMKVLKGG----------CGCQNHDPNLSAS 46  Bacteroides sp. 2_1_7
ZP_05283863    1 MKKLSKIKLNHLNDd--eLKNREMNNLRGGRI--------CGCGCNYADSGGS 43  Bacteroides fragilis 3_1_12
ZP_04844675    3 MKKLSKIKLTNLSQe--dLADREMNALRGGHN--------CGCACSSTSKATN 45  Bacteroides sp. 3_2_5
ZP_06095352    1 MKTLRRIKLNSLSQe--dLADREMNMLRGGSN--------CSCGCMGVSSKAS 43  Bacteroides sp. 2_1_16
WP_005791224   1 MRKLSEIKLGQLNKv--eLSERELNRLLGGSN--------C-CICHNRGSATl 42  Bacteroides fragilis
WP_012929189   3 KNSLKSTKLQLNTEkiakLSDQEMSTLFGGG---------STCSSFTCTSCAA 46  Spirosoma linguale
WP_008770117   1 MKKISVLKLGNLDKk--cLEEKEMDRLVGGNY--------CAGTTANQVANTY 43  Bacteroides
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